CAS OpenIR
Hydrogel-based preparation of cell aggregates for biomedical applications
Zhang, Jiabin1; Yun, Seonho1; Du, Yuguang4; Zannettino, Andrew2; Zhang, Hu1,3
2020-09-01
Source PublicationAPPLIED MATERIALS TODAY
ISSN2352-9407
Volume20Pages:19
AbstractCell aggregates are widely used either as in-vitro models for drug screening, fundamental studies on disease progression and developmental biology, as well as in-vivo injectable cells for tissue regeneration. Compared to single-cell suspensions, cell aggregates retain superior cell viability, mimic in-vivo microenvironments and enhance functional properties, such as superior anti-inflammatory properties of mesenchymal stem/stromal cell aggregates or enhanced albumin production by hepatocyte aggregates. Cell aggregates can be either prepared by conventional spontaneous aggregation, or advanced substrate based and technology-assisted methods, which have been well described in previous reviews. However, hydrogel-based preparation of cell aggregates is a novel, hitherto rarely considered method compared to conventional preparation of cell aggregates, such as hanging drops and commercial AggreWellTM plates. This review will mainly focus on two-dimensional (2D) hydrogel surface-based and three-dimensional (3D) hydrogel embedding-based preparation of cell aggregates by revealing the underlying mechanisms and highlighting some of their potential biomedical applications. (c) 2020 Elsevier Ltd. All rights reserved.
Keyword2D 3D Hydrogel Cell aggregate Biomedical application
DOI10.1016/j.apmt.2020.100747
Language英语
WOS KeywordMESENCHYMAL STEM-CELLS ; POLY(ETHYLENE GLYCOL) HYDROGELS ; IN-VITRO ; HYALURONIC-ACID ; EMBRYOID BODIES ; STROMAL CELLS ; THERAPEUTIC NEOVASCULARIZATION ; CHONDROGENIC DIFFERENTIATION ; TISSUE RECONSTRUCTION ; RESPONSIVE HYDROGELS
Funding ProjectARC Discovery Project[DP160104632] ; Medical Advancement Without Animal (MAWA) Trust ; IPE-UoA Scholarship (BES)
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Multidisciplinary
Funding OrganizationARC Discovery Project ; Medical Advancement Without Animal (MAWA) Trust ; IPE-UoA Scholarship (BES)
WOS IDWOS:000598356100014
PublisherELSEVIER
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/42917
Collection中国科学院过程工程研究所
Corresponding AuthorZannettino, Andrew; Zhang, Hu
Affiliation1.Univ Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia
2.Univ Adelaide, Adelaide Med Sch, Adelaide, SA 5001, Australia
3.Keck Grad Inst, Henry E Riggs Sch Appl Life Sci, Claremont, CA 91711 USA
4.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Jiabin,Yun, Seonho,Du, Yuguang,et al. Hydrogel-based preparation of cell aggregates for biomedical applications[J]. APPLIED MATERIALS TODAY,2020,20:19.
APA Zhang, Jiabin,Yun, Seonho,Du, Yuguang,Zannettino, Andrew,&Zhang, Hu.(2020).Hydrogel-based preparation of cell aggregates for biomedical applications.APPLIED MATERIALS TODAY,20,19.
MLA Zhang, Jiabin,et al."Hydrogel-based preparation of cell aggregates for biomedical applications".APPLIED MATERIALS TODAY 20(2020):19.
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