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| Hydrogel-based preparation of cell aggregates for biomedical applications | |
| Zhang, Jiabin1; Yun, Seonho1; Du, Yuguang4; Zannettino, Andrew2; Zhang, Hu1,3 | |
| 2020-09-01 | |
| Source Publication | APPLIED MATERIALS TODAY
 |
| ISSN | 2352-9407 |
| Volume | 20Pages:19 |
| Abstract | Cell aggregates are widely used either as in-vitro models for drug screening, fundamental studies on disease progression and developmental biology, as well as in-vivo injectable cells for tissue regeneration. Compared to single-cell suspensions, cell aggregates retain superior cell viability, mimic in-vivo microenvironments and enhance functional properties, such as superior anti-inflammatory properties of mesenchymal stem/stromal cell aggregates or enhanced albumin production by hepatocyte aggregates. Cell aggregates can be either prepared by conventional spontaneous aggregation, or advanced substrate based and technology-assisted methods, which have been well described in previous reviews. However, hydrogel-based preparation of cell aggregates is a novel, hitherto rarely considered method compared to conventional preparation of cell aggregates, such as hanging drops and commercial AggreWellTM plates. This review will mainly focus on two-dimensional (2D) hydrogel surface-based and three-dimensional (3D) hydrogel embedding-based preparation of cell aggregates by revealing the underlying mechanisms and highlighting some of their potential biomedical applications. (c) 2020 Elsevier Ltd. All rights reserved. |
| Keyword | 2D 3D Hydrogel Cell aggregate Biomedical application |
| DOI | 10.1016/j.apmt.2020.100747 |
| Language | 英语 |
| WOS Keyword | MESENCHYMAL STEM-CELLS ; POLY(ETHYLENE GLYCOL) HYDROGELS ; IN-VITRO ; HYALURONIC-ACID ; EMBRYOID BODIES ; STROMAL CELLS ; THERAPEUTIC NEOVASCULARIZATION ; CHONDROGENIC DIFFERENTIATION ; TISSUE RECONSTRUCTION ; RESPONSIVE HYDROGELS |
| Funding Project | ARC Discovery Project[DP160104632] ; Medical Advancement Without Animal (MAWA) Trust ; IPE-UoA Scholarship (BES) |
| WOS Research Area | Materials Science |
| WOS Subject | Materials Science, Multidisciplinary |
| Funding Organization | ARC Discovery Project ; Medical Advancement Without Animal (MAWA) Trust ; IPE-UoA Scholarship (BES) |
| WOS ID | WOS:000598356100014 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/42917 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Zannettino, Andrew; Zhang, Hu |
| Affiliation | 1.Univ Adelaide, Sch Chem Engn, Adelaide, SA 5005, Australia 2.Univ Adelaide, Adelaide Med Sch, Adelaide, SA 5001, Australia 3.Keck Grad Inst, Henry E Riggs Sch Appl Life Sci, Claremont, CA 91711 USA 4.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Jiabin,Yun, Seonho,Du, Yuguang,et al. Hydrogel-based preparation of cell aggregates for biomedical applications[J]. APPLIED MATERIALS TODAY,2020,20:19. |
| APA | Zhang, Jiabin,Yun, Seonho,Du, Yuguang,Zannettino, Andrew,&Zhang, Hu.(2020).Hydrogel-based preparation of cell aggregates for biomedical applications.APPLIED MATERIALS TODAY,20,19. |
| MLA | Zhang, Jiabin,et al."Hydrogel-based preparation of cell aggregates for biomedical applications".APPLIED MATERIALS TODAY 20(2020):19. |
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