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Chitosan Oligosaccharides Coupling Inhibits Bacterial Biofilm-Related Antibiotic Resistance against Florfenicol
Yuan, Xianghua1; Liu, Jing2; Li, Ruilian2,3; Zhou, Junlin1; Wei, Jinhua2; Jiao, Siming2; Wang, Zhuo A.2,3; Du, Yuguang2,3
2020-12-01
Source PublicationMOLECULES
Volume25Issue:24Pages:10
AbstractThe formation of bacterial biofilms has increased the resistance of bacteria to various environmental factors and is tightly associated with many persistent and chronic bacterial infections. Herein we design a strategy conjugating florfenicol, an antibiotic commonly used in the treatment of streptococcus, with the antimicrobial biomaterial, chitosan oligosaccharides. The results demonstrated that the florfenicol-COS conjugate (F-COS) efficiently eradicated the mature Streptococcus hyovaginalis biofilm, apparently inhibiting drug resistance to florfenicol. A quantity of 250 mu g/mL F-COS showed effective inhibitory activity against planktonic cells and biofilm of the bacteria, and a 4-fold improvement of the F-COS compared to unmodified florfenicol was observed. Furthermore, the conjugate showed a broad-spectrum activity against both Gram-positive and Gram-negative bacteria. It suggested that F-COS might have a potential for application in the treatment of biofilm-related infections.
Keywordbiofilm florfenicol chitosan oligosaccharide antibiotic resistance
DOI10.3390/molecules25246043
Language英语
WOS KeywordSTREPTOCOCCUS-SUIS ; CHLORAMPHENICOL ; PHARMACOKINETICS ; MENINGITIS ; AMINE
Funding ProjectNational Key R&D Program of China[2017YFD0502300] ; National Natural Science Foundation of China[31670809]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Multidisciplinary
Funding OrganizationNational Key R&D Program of China ; National Natural Science Foundation of China
WOS IDWOS:000603239700001
PublisherMDPI
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/42976
Collection中国科学院过程工程研究所
Corresponding AuthorWang, Zhuo A.; Du, Yuguang
Affiliation1.Sichuan Normal Univ, Coll Life Sci, Chengdu 610101, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Coll Chem & Chem Engn, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yuan, Xianghua,Liu, Jing,Li, Ruilian,et al. Chitosan Oligosaccharides Coupling Inhibits Bacterial Biofilm-Related Antibiotic Resistance against Florfenicol[J]. MOLECULES,2020,25(24):10.
APA Yuan, Xianghua.,Liu, Jing.,Li, Ruilian.,Zhou, Junlin.,Wei, Jinhua.,...&Du, Yuguang.(2020).Chitosan Oligosaccharides Coupling Inhibits Bacterial Biofilm-Related Antibiotic Resistance against Florfenicol.MOLECULES,25(24),10.
MLA Yuan, Xianghua,et al."Chitosan Oligosaccharides Coupling Inhibits Bacterial Biofilm-Related Antibiotic Resistance against Florfenicol".MOLECULES 25.24(2020):10.
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