Knowledge Management System Of Institute of process engineering,CAS
| Sprayed Pickering emulsion with high antibacterial activity for wound healing | |
| Bao, Xieru1,2; Wu, Jie1,2,3,4; Ma, Guanghui1,2,3,4 | |
| 2020-10-01 | |
| Source Publication | PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL
 |
| ISSN | 1002-0071 |
| Volume | 30Issue:5Pages:669-676 |
| Abstract | Effective treatment of wound injuries can prevent infections and promote healing. In this work, a sprayed Pickering emulsion composed of chitosan nanoparticles, tea tree oil and curcumin was formulated. The shear thinning behaviour allowed this Pickering emulsion to spray even with a high viscosity provided by the aqueous phase containing chitosan nanoparticles. Moreover, the Pickering emulsion could recover to the high viscosity after spraying onto the wounds, leading to the long residence time and intimate contact. In addition, the Pickering emulsion provided a carrier to encapsulate the tea tree oil, which caused sustained-release effects and further strengthened tea tree oil's antibacterial activity towards the Gram-negative Escherichia coli (E. coli), Gram-positive Staphylococcus aureus (S. aureus) and Gram-positive methicillin-resistant Staphylococcus aureus (MRSA). Besides, this multi-phase system offered a platform to load with hydrophobic curcumin, leading to better synergistic healing effects. Meanwhile, the Pickering emulsion avoided the irritation and toxicity related to surfactants, which was far safer than the classical emulsion especially when used in the defective skin. All these excellent properties endowed this sprayed Pickering emulsion with promising prospects for wound healing. |
| Keyword | Pickering emulsion Wound healing Chitosan nanoparticles High viscosity Antibacterial activity |
| DOI | 10.1016/j.pnsc.2020.08.001 |
| Language | 英语 |
| WOS Keyword | TEA TREE OIL ; IN-VITRO ; HYDROGEL ; SKIN ; PARTICLES ; NANOPARTICLES ; MEMBRANE ; DELIVERY ; SYSTEM |
| Funding Project | National Key R&D Program of China, China[2018YFC0311303] ; Key Research Program of the Chinese Academy of Sciences, China[KFZD-SW-218] ; International Cooperation Project of the Chinese Academy of Sciences, China[122111KYSB20180021] ; National Natural Science Foundation of China[21776287] |
| WOS Research Area | Materials Science ; Science & Technology - Other Topics |
| WOS Subject | Materials Science, Multidisciplinary ; Multidisciplinary Sciences |
| Funding Organization | National Key R&D Program of China, China ; Key Research Program of the Chinese Academy of Sciences, China ; International Cooperation Project of the Chinese Academy of Sciences, China ; National Natural Science Foundation of China |
| WOS ID | WOS:000604439100004 |
| Publisher | ELSEVIER SCIENCE INC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/43040 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Wu, Jie; Ma, Guanghui |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, PLA Key Lab Biopharmaceut Prod & Formulat Engn, Beijing, Peoples R China 4.Jiangsu Natl Synerget Innovat Ctr Adv Mat, Nanjing, Peoples R China |
| Recommended Citation GB/T 7714 | Bao, Xieru,Wu, Jie,Ma, Guanghui. Sprayed Pickering emulsion with high antibacterial activity for wound healing[J]. PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL,2020,30(5):669-676. |
| APA | Bao, Xieru,Wu, Jie,&Ma, Guanghui.(2020).Sprayed Pickering emulsion with high antibacterial activity for wound healing.PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL,30(5),669-676. |
| MLA | Bao, Xieru,et al."Sprayed Pickering emulsion with high antibacterial activity for wound healing".PROGRESS IN NATURAL SCIENCE-MATERIALS INTERNATIONAL 30.5(2020):669-676. |
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