CAS OpenIR
Black phosphorus quantum dots encapsulated in anionic waterborne polyurethane nanoparticles for enhancing stability and reactive oxygen species generation for cancer PDT/PTT therapy
Lu, Fengying1,2; Li, Zhengjun2; Kang, Yong2,3; Su, Zhiguo2; Yu, Rong1; Zhang, Songping2
2020-12-14
Source PublicationJOURNAL OF MATERIALS CHEMISTRY B
ISSN2050-750X
Volume8Issue:46Pages:10650-10661
AbstractBlack phosphorus quantum dots (BPQDs) with excellent biocompatibility, outstanding photothermal and photodynamic efficacies have attracted significant attention in cancer therapy. However, the low environmental stability and poor dispersity of BPQDs limit their practical applications. In the present work, biocompatible anionic waterborne polyurethane (WPU) nanoparticles were synthesized from castor oil to encapsulate the BPQDs. The WPU-BPQDs with a BPQDs loading capacity of about 13.8% (w/w) exhibited significantly improved dispersion and environmental stability without affecting the photothermal efficiency of BPQDs. Intriguingly, it was found that WPU encapsulation led to significant enhancement in the reactive oxygen species (ROS) generation of BPQDs, which indicated the enhanced photodynamic efficacy of the encapsulated BPQDs as compared to the bare BPQDs. The effect of solution pH on the ROS generation efficiency of BPQDs and the pH variation caused by BPQDs degradation was then investigated to explore the possible mechanism. In acidic solution, ROS generation was suppressed, while BPQDs degradation led to the acidification of the solution. Fortunately, after being encapsulated inside the WPU nanoparticles, the degradation rate of BPQDs became slower, while the acidic environment around BPQDs was favorably regulated by WPU nanoparticles having a special electrochemical double layer consisting of interior COO- and exterior NH(Et-3)(+), thus endowing the WPU-BPQDs-boosted production of ROS as compared to the bare BPQDs. Considering the undesired acidic tumor environment, this unique pH regulation effect of WPU-BPQDs would be beneficial for in vivo photodynamic efficacy. Both in vitro and in vivo experiments showed that WPU-BPQDs could effectively improve photodynamic therapy (PDT) and maintain outstanding photothermal therapy (PTT) effects. Together with the excellent dispersity, biocompatibility, and easy biodegradability, WPU-BPQDs can be a promising agent for PDT/PTT cancer treatments.
DOI10.1039/d0tb02101f
Language英语
WOS KeywordPHOTOTHERMAL THERAPY ; DRUG-DELIVERY ; NANOSHEETS ; MICELLES ; NANOCARRIERS ; DESIGN
Funding ProjectNational Natural Science Foundation of China[21676276]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
Funding OrganizationNational Natural Science Foundation of China
WOS IDWOS:000608190300017
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/43135
Collection中国科学院过程工程研究所
Corresponding AuthorYu, Rong; Zhang, Songping
Affiliation1.Sichuan Univ, West China Sch Pharm, Minist Educ, Key Lab Drug Targeting & Drug Delivery Syst, Chengdu 610041, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Lu, Fengying,Li, Zhengjun,Kang, Yong,et al. Black phosphorus quantum dots encapsulated in anionic waterborne polyurethane nanoparticles for enhancing stability and reactive oxygen species generation for cancer PDT/PTT therapy[J]. JOURNAL OF MATERIALS CHEMISTRY B,2020,8(46):10650-10661.
APA Lu, Fengying,Li, Zhengjun,Kang, Yong,Su, Zhiguo,Yu, Rong,&Zhang, Songping.(2020).Black phosphorus quantum dots encapsulated in anionic waterborne polyurethane nanoparticles for enhancing stability and reactive oxygen species generation for cancer PDT/PTT therapy.JOURNAL OF MATERIALS CHEMISTRY B,8(46),10650-10661.
MLA Lu, Fengying,et al."Black phosphorus quantum dots encapsulated in anionic waterborne polyurethane nanoparticles for enhancing stability and reactive oxygen species generation for cancer PDT/PTT therapy".JOURNAL OF MATERIALS CHEMISTRY B 8.46(2020):10650-10661.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Lu, Fengying]'s Articles
[Li, Zhengjun]'s Articles
[Kang, Yong]'s Articles
Baidu academic
Similar articles in Baidu academic
[Lu, Fengying]'s Articles
[Li, Zhengjun]'s Articles
[Kang, Yong]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Lu, Fengying]'s Articles
[Li, Zhengjun]'s Articles
[Kang, Yong]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.