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| Self-Activatable Photo-Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy | |
| Ding, Jingjing1; Lu, Guihong2; Nie, Weidong1; Huang, Li-Li1; Zhang, Yahui1; Fan, Wenlin1; Wu, Guanghao1; Liu, Houli1; Xie, Hai-Yan1 | |
| 2021-01-12 | |
| Source Publication | ADVANCED MATERIALS
 |
| ISSN | 0935-9648 |
| Pages | 12 |
| Abstract | Extracellular vesicles (EVs) hold great potential in both disease treatment and drug delivery. However, accurate drug release from EVs, as well as the spontaneous treatment effect cooperation of EVs and drugs at target tissues, is still challenging. Here, an engineered self-activatable photo-EV for synergistic trimodal anticancer therapy is reported. M1 macrophage-derived EVs (M1 EVs) are simultaneously loaded with bis[2,4,5-trichloro-6-(pentyloxycarbonyl) phenyl] oxalate (CPPO), chlorin e6 (Ce6), and prodrug aldoxorubicin (Dox-EMCH). After administration, the as-prepared system actively targets tumor cells because of the tumor-homing capability of M1 EVs, wherein M1 EVs repolarize M2 to M1 macrophages, which not only display immunotherapy effects but also produce H2O2. The reaction between H2O2 and CPPO generates chemical energy that activates Ce6, creating both chemiluminescence for imaging and singlet oxygen (O-1(2)) for photodynamic therapy (PDT). Meanwhile, O-1(2)-induced membrane rupture leads to the release of Dox-EMCH, which is then activated and penetrates the deep hypoxic areas of tumors. The synergism of immunotherapy, PDT, and chemotherapy results in potent anticancer efficacy, showing great promise to fight cancers. |
| Keyword | chemotherapy extracellular vesicle immunotherapy photodynamic therapy tumor microenvironment |
| DOI | 10.1002/adma.202005562 |
| Language | 英语 |
| WOS Keyword | TUMOR-ASSOCIATED MACROPHAGES ; HYDROGEN-PEROXIDE ; EXOSOMES ; DRUG ; NANOPARTICLES ; DELIVERY ; CHEMILUMINESCENCE ; PACLITAXEL ; PHENOTYPE |
| Funding Project | National Science Foundation of China[21874011] ; National Science Foundation of China[91859213] ; National Science Foundation of China[22025401] |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS Subject | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| Funding Organization | National Science Foundation of China |
| WOS ID | WOS:000606809100001 |
| Publisher | WILEY-V C H VERLAG GMBH |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/43155 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Xie, Hai-Yan |
| Affiliation | 1.Beijing Inst Technol, Sch Life Sci, Beijing 100081, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Ding, Jingjing,Lu, Guihong,Nie, Weidong,et al. Self-Activatable Photo-Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy[J]. ADVANCED MATERIALS,2021:12. |
| APA | Ding, Jingjing.,Lu, Guihong.,Nie, Weidong.,Huang, Li-Li.,Zhang, Yahui.,...&Xie, Hai-Yan.(2021).Self-Activatable Photo-Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy.ADVANCED MATERIALS,12. |
| MLA | Ding, Jingjing,et al."Self-Activatable Photo-Extracellular Vesicle for Synergistic Trimodal Anticancer Therapy".ADVANCED MATERIALS (2021):12. |
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