CAS OpenIR
Nanovaccine's rapid induction of anti-tumor immunity significantly improves malignant cancer immunotherapy
Zhang, Ling-xiao1,2,4; Sun, Xia-mei1; Jia, Ying-bo1,4; Liu, Xiao-ge1,4; Dong, Mingdong3; Xu, Zhi Ping2; Liu, Rui-tian1
2020-12-01
Source PublicationNANO TODAY
ISSN1748-0132
Volume35Pages:12
AbstractThe advantage of rapid tumor growth over slow immune induction often limits the efficiency of cancer therapeutic vaccines. Many functionalized micro-/nano-vaccines are shown to enhance cancer immunotherapy, but few studies correlate the therapeutic efficacy of these micro-/nano-vaccines to the vaccination route such as intravenous (IV), subcutaneous (SC) injection or their combination. Herein, we employed classical "priming + boosting" vaccination strategy to investigate the influence of four vaccination combinations (IV + IV, IV + SC, SC + IV and SC + SC) of nanovaccines on the anti-tumor therapeutic efficacy in mice bearing E.G7-OVA-lymphoma and B16F10-melanoma. The nanovaccines were constructed by loading antigen and CpG onto layered double hydroxide (LDH) nanoparticles. Our experimental data indicate that "IV-priming + SC-boosting" vaccination combination most efficiently inhibits the growth of early stage tumors, with the tumor volume reduced by >75-90 % in comparison with the control group. Based on these findings, a novel vaccination strategy, i.e. simultaneous IV and SC injection was proposed, which significantly delayed the progression of both early stage and advanced Bl6F10 tumors. Our current research for the first time correlates the vaccination route of nanovaccines to the anti-tumor therapeutic efficacy, and the highest efficacy of optimal vaccination combination (IV + SC) is benefited from that fact that IV priming quickly induces strong anti-tumor responses that are well sustained by subsequent SC boosting. Moreover, the simultaneous IV/SC vaccination potentially provides a novel vaccination strategy for enhanced immunotherapy of early stage and advanced tumors. (C) 2020 Elsevier Ltd. All rights reserved.
KeywordMalignant cancer immunotherapy Layered double hydroxide based nanovaccine Vaccination routes Quick induction of anti-tumor immunity
DOI10.1016/j.nantod.2020.100923
Language英语
WOS KeywordDOUBLE HYDROXIDE NANOPARTICLES ; DENDRITIC CELLS ; THERAPEUTIC VACCINES ; ADMINISTRATION ROUTE ; MELANOMA TUMOR ; CO-DELIVERY ; EXPRESSION ; EFFICIENT ; RESPONSES ; ADJUVANT
Funding ProjectInternational Partnership Program of Chinese Academy of Sciences[122111KYSB20180005] ; Australian Research Council (ARC)[DP170104643] ; Australian Research Council (ARC)[DP190103486] ; Danish National Research Foundation[904000219B] ; European Union[734174] ; UCAS Joint PhD Training Program[2018-23]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationInternational Partnership Program of Chinese Academy of Sciences ; Australian Research Council (ARC) ; Danish National Research Foundation ; European Union ; UCAS Joint PhD Training Program
WOS IDWOS:000600849700004
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/43165
Collection中国科学院过程工程研究所
Corresponding AuthorXu, Zhi Ping; Liu, Rui-tian
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Queensland, Australian Inst Bioengn & Nanotechnol, St Lucia, Qld 4072, Australia
3.Aarhus Univ, Interdisciplinary Nanosci Ctr iNANO, Sino Danish Ctr Educ & Res SDC, DK-8000 Aarhus C, Denmark
4.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Ling-xiao,Sun, Xia-mei,Jia, Ying-bo,et al. Nanovaccine's rapid induction of anti-tumor immunity significantly improves malignant cancer immunotherapy[J]. NANO TODAY,2020,35:12.
APA Zhang, Ling-xiao.,Sun, Xia-mei.,Jia, Ying-bo.,Liu, Xiao-ge.,Dong, Mingdong.,...&Liu, Rui-tian.(2020).Nanovaccine's rapid induction of anti-tumor immunity significantly improves malignant cancer immunotherapy.NANO TODAY,35,12.
MLA Zhang, Ling-xiao,et al."Nanovaccine's rapid induction of anti-tumor immunity significantly improves malignant cancer immunotherapy".NANO TODAY 35(2020):12.
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