CAS OpenIR
The immunodominant and neutralization linear epitopes for SARS-CoV-2
Lu, Shuai1,2; Xie, Xi-xiu1,2; Zhao, Lei3; Wang, Bin1,2; Zhu, Jie1,2; Yang, Ting-rui1,2; Yang, Guang-wen4; Ji, Mei1; Lv, Cui-ping1; Xue, Jian3; Dai, Er-hei3; Fu, Xi-ming5,6; Liu, Dong-qun1; Zhang, Lun1; Hou, Sheng-jie1; Yu, Xiao-lin1,2; Wang, Yu-ling3; Gao, Hui-xia3; Shi, Xue-han3; Ke, Chang-wen3; Ke, Bi-xia7; Jiang, Chun-guo8; Liu, Rui-tian1,2
2021-01-26
Source PublicationCELL REPORTS
ISSN2211-1247
Volume34Issue:4Pages:12
AbstractAlthough vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are under development, the antigen epitopes on the virus and their immunogenicity are poorly understood. Here, we simulate the 3D structures and predict the B cell epitopes on the spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins of SARS-CoV-2 using structure-based approaches and validate epitope immunogenicity by immunizing mice. Almost all 33 predicted epitopes effectively induce antibody production, six of these are immunodominant epitopes in individuals, and 23 are conserved within SARS-CoV-2, SARS-CoV, and bat coronavirus RaTG13. We find that the immunodominant epitopes of individuals with domestic (China) SARS-CoV-2 are different from those of individuals with imported (Europe) SARS-CoV-2, which may be caused by mutations on the S (G614D) and N proteins. Importantly, we find several epitopes on the S protein that elicit neutralizing antibodies against D614 and G614 SARS-CoV-2, which can contribute to vaccine design against coronaviruses.
DOI10.1016/j.celrep.2020.108666
Language英语
WOS KeywordCORONAVIRUS ; ANTIBODIES ; PEPTIDES ; VACCINE
Funding ProjectNational Natural Science Foundation of China[81971610] ; National Natural Science Foundation of China[81971073] ; National Natural Science Foundation of China[81903531] ; National Science and Technology Major Projects of New Drugs[2018ZX09733001-001-008] ; Innovation Academy for Green Manufacture, Chinese Academy of Sciences[IAGM2020C29] ; Zhejiang University Special Scientific Research Fund for COVID-19 Prevention and Control[2020XGZX075]
WOS Research AreaCell Biology
WOS SubjectCell Biology
Funding OrganizationNational Natural Science Foundation of China ; National Science and Technology Major Projects of New Drugs ; Innovation Academy for Green Manufacture, Chinese Academy of Sciences ; Zhejiang University Special Scientific Research Fund for COVID-19 Prevention and Control
WOS IDWOS:000613631500008
PublisherCELL PRESS
Citation statistics
Cited Times:1[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/43434
Collection中国科学院过程工程研究所
Corresponding AuthorJiang, Chun-guo; Liu, Rui-tian
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Innovat Acad Green Manufacture, Beijing 100190, Peoples R China
3.Shijiazhuang Fifth Hosp, Dept Internal Med 2, Shijiazhuang 050021, Hebei, Peoples R China
4.Tsinghua Univ, Dept Comp Sci & Technol, Beijing 100084, Peoples R China
5.Chinese Univ Hong Kong, Shenzhen 518172, Peoples R China
6.Univ Sci & Technol, Hefei 230026, Peoples R China
7.Guangdong Prov Ctr Dis Control & Prevent, Guangzhou 511430, Peoples R China
8.Capital Med Univ, Beijing Inst Resp Med, Dept Resp & Crit Care Med, Beijing Chaoyang Hosp, Beijing 100020, Peoples R China
Recommended Citation
GB/T 7714
Lu, Shuai,Xie, Xi-xiu,Zhao, Lei,et al. The immunodominant and neutralization linear epitopes for SARS-CoV-2[J]. CELL REPORTS,2021,34(4):12.
APA Lu, Shuai.,Xie, Xi-xiu.,Zhao, Lei.,Wang, Bin.,Zhu, Jie.,...&Liu, Rui-tian.(2021).The immunodominant and neutralization linear epitopes for SARS-CoV-2.CELL REPORTS,34(4),12.
MLA Lu, Shuai,et al."The immunodominant and neutralization linear epitopes for SARS-CoV-2".CELL REPORTS 34.4(2021):12.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Lu, Shuai]'s Articles
[Xie, Xi-xiu]'s Articles
[Zhao, Lei]'s Articles
Baidu academic
Similar articles in Baidu academic
[Lu, Shuai]'s Articles
[Xie, Xi-xiu]'s Articles
[Zhao, Lei]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Lu, Shuai]'s Articles
[Xie, Xi-xiu]'s Articles
[Zhao, Lei]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.