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| The immunodominant and neutralization linear epitopes for SARS-CoV-2 | |
| Lu, Shuai1,2; Xie, Xi-xiu1,2; Zhao, Lei3; Wang, Bin1,2; Zhu, Jie1,2; Yang, Ting-rui1,2; Yang, Guang-wen4; Ji, Mei1; Lv, Cui-ping1; Xue, Jian3; Dai, Er-hei3; Fu, Xi-ming5,6; Liu, Dong-qun1; Zhang, Lun1; Hou, Sheng-jie1; Yu, Xiao-lin1,2; Wang, Yu-ling3; Gao, Hui-xia3; Shi, Xue-han3; Ke, Chang-wen3; Ke, Bi-xia7; Jiang, Chun-guo8; Liu, Rui-tian1,2 | |
| 2021-01-26 | |
| Source Publication | CELL REPORTS
 |
| ISSN | 2211-1247 |
| Volume | 34Issue:4Pages:12 |
| Abstract | Although vaccines against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are under development, the antigen epitopes on the virus and their immunogenicity are poorly understood. Here, we simulate the 3D structures and predict the B cell epitopes on the spike (S), envelope (E), membrane (M), and nucleocapsid (N) proteins of SARS-CoV-2 using structure-based approaches and validate epitope immunogenicity by immunizing mice. Almost all 33 predicted epitopes effectively induce antibody production, six of these are immunodominant epitopes in individuals, and 23 are conserved within SARS-CoV-2, SARS-CoV, and bat coronavirus RaTG13. We find that the immunodominant epitopes of individuals with domestic (China) SARS-CoV-2 are different from those of individuals with imported (Europe) SARS-CoV-2, which may be caused by mutations on the S (G614D) and N proteins. Importantly, we find several epitopes on the S protein that elicit neutralizing antibodies against D614 and G614 SARS-CoV-2, which can contribute to vaccine design against coronaviruses. |
| DOI | 10.1016/j.celrep.2020.108666 |
| Language | 英语 |
| WOS Keyword | CORONAVIRUS ; ANTIBODIES ; PEPTIDES ; VACCINE |
| Funding Project | National Natural Science Foundation of China[81971610] ; National Natural Science Foundation of China[81971073] ; National Natural Science Foundation of China[81903531] ; National Science and Technology Major Projects of New Drugs[2018ZX09733001-001-008] ; Innovation Academy for Green Manufacture, Chinese Academy of Sciences[IAGM2020C29] ; Zhejiang University Special Scientific Research Fund for COVID-19 Prevention and Control[2020XGZX075] |
| WOS Research Area | Cell Biology |
| WOS Subject | Cell Biology |
| Funding Organization | National Natural Science Foundation of China ; National Science and Technology Major Projects of New Drugs ; Innovation Academy for Green Manufacture, Chinese Academy of Sciences ; Zhejiang University Special Scientific Research Fund for COVID-19 Prevention and Control |
| WOS ID | WOS:000613631500008 |
| Publisher | CELL PRESS |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/43434 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Jiang, Chun-guo; Liu, Rui-tian |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Chinese Acad Sci, Innovat Acad Green Manufacture, Beijing 100190, Peoples R China 3.Shijiazhuang Fifth Hosp, Dept Internal Med 2, Shijiazhuang 050021, Hebei, Peoples R China 4.Tsinghua Univ, Dept Comp Sci & Technol, Beijing 100084, Peoples R China 5.Chinese Univ Hong Kong, Shenzhen 518172, Peoples R China 6.Univ Sci & Technol, Hefei 230026, Peoples R China 7.Guangdong Prov Ctr Dis Control & Prevent, Guangzhou 511430, Peoples R China 8.Capital Med Univ, Beijing Inst Resp Med, Dept Resp & Crit Care Med, Beijing Chaoyang Hosp, Beijing 100020, Peoples R China |
| Recommended Citation GB/T 7714 | Lu, Shuai,Xie, Xi-xiu,Zhao, Lei,et al. The immunodominant and neutralization linear epitopes for SARS-CoV-2[J]. CELL REPORTS,2021,34(4):12. |
| APA | Lu, Shuai.,Xie, Xi-xiu.,Zhao, Lei.,Wang, Bin.,Zhu, Jie.,...&Liu, Rui-tian.(2021).The immunodominant and neutralization linear epitopes for SARS-CoV-2.CELL REPORTS,34(4),12. |
| MLA | Lu, Shuai,et al."The immunodominant and neutralization linear epitopes for SARS-CoV-2".CELL REPORTS 34.4(2021):12. |
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