CAS OpenIR
Intracellular Paclitaxel Delivery Facilitated by a Dual-Functional CPP with a Hydrophobic Hairpin Tail
Wei, Yuping1,2; Zhang, Man3; Jiao, Pengfei1; Zhang, Xin1; Yang, Ganggang4,5; Xu, Xia2,4,5
2021-02-03
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume13Issue:4Pages:4853-4860
AbstractIn our pervious study, a dual-functional peptide R7 was developed to form a complex with paclitaxel (PTX) for enhancement of PTX translocation. However, because of the unstable noncovalent bond between R7 and PTX, PTX redistributed after the introduction of heparin, leading to R7-PTX complex dissociation, further causing less PTX penetration than expected. Thus, a novel positive CPP carrier of P9 was developed to improve CPP-PTX affinity via a double-proline (Pro, P) hairpin tail and enhance PTX translocation through the reduction of translocation energy barrier, confirmed by the MM-PBSA analysis and umbrella sampling simulation. Cellular uptake study reveals that P9 can quickly translocate into the HeLa cells within 1 min and exhibits no noticeable cytotoxicity. Compared to R7, P9 is able to help PTX translocation, leading to a remarkable increase in the intracellular concentration of PTX, eventually resulting in a significant loss in tumor cell viability. In vivo experiments demonstrate that a vein injection of P9-PTX complex dramatically inhibits tumor growth. Our study provides a novel perspective for designing CPP-facilitated drug carrier to enhance antitumor efficiency.
Keyworddual-functional peptide cell penetrating peptide paclitaxel intracellular drug delivery double-proline hairpin tail
DOI10.1021/acsami.0c20180
Language英语
WOS KeywordPEPTIDES
Funding ProjectNational Natural Science Foundation of China[21506230] ; National Natural Science Foundation of China[21978001] ; National Natural Science Foundation of China[21606239] ; National Natural Science Foundation of China[31770138] ; National Natural Science Foundation of China[31570120] ; Wanjiang Scholar Program and Start Fund from Anhui University of Technology ; Scientific and Technological Project of Henan Province[202102310537] ; School-level Research Project of Nanyang Normal University[2019ZX012]
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; Wanjiang Scholar Program and Start Fund from Anhui University of Technology ; Scientific and Technological Project of Henan Province ; School-level Research Project of Nanyang Normal University
WOS IDWOS:000618153100004
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/43444
Collection中国科学院过程工程研究所
Corresponding AuthorXu, Xia
Affiliation1.Nanyang Normal Univ, Sch Life Sci & Technol, Nanyang 473061, Henan, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Nanyang First Peoples Hosp, Dept Oncol, Nanyang 473002, Henan, Peoples R China
4.Anhui Univ Technol, Biochem Engn Res Ctr, Maanshan 243032, Henan, Peoples R China
5.Anhui Univ Technol, Sch Chem & Chem Engn, Maanshan 243032, Henan, Peoples R China
Recommended Citation
GB/T 7714
Wei, Yuping,Zhang, Man,Jiao, Pengfei,et al. Intracellular Paclitaxel Delivery Facilitated by a Dual-Functional CPP with a Hydrophobic Hairpin Tail[J]. ACS APPLIED MATERIALS & INTERFACES,2021,13(4):4853-4860.
APA Wei, Yuping,Zhang, Man,Jiao, Pengfei,Zhang, Xin,Yang, Ganggang,&Xu, Xia.(2021).Intracellular Paclitaxel Delivery Facilitated by a Dual-Functional CPP with a Hydrophobic Hairpin Tail.ACS APPLIED MATERIALS & INTERFACES,13(4),4853-4860.
MLA Wei, Yuping,et al."Intracellular Paclitaxel Delivery Facilitated by a Dual-Functional CPP with a Hydrophobic Hairpin Tail".ACS APPLIED MATERIALS & INTERFACES 13.4(2021):4853-4860.
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