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| Experimental and theoretical explorations of nanocarriers' multistep delivery performance for rational design and anticancer prediction | |
| Bao, Weier1,2; Tian, Falin3; Lyu, Chengliang2; Liu, Bin1; Li, Bin3; Zhang, Luyao3; Liu, Xianwu1,2; Li, Feng2; Li, Dan1; Gao, Xiaoyong2; Wang, Shuo2; Wei, Wei2,4; Shi, Xinghua3,4; Li, Yuan1 | |
| 2021-02-01 | |
| Source Publication | SCIENCE ADVANCES
 |
| ISSN | 2375-2548 |
| Volume | 7Issue:6Pages:15 |
| Abstract | The poor understanding of the complex multistep process taken by nanocarriers during the delivery process limits the delivery efficiencies and further hinders the translation of these systems into medicine. Here, we describe a series of six self-assembled nanocarrier types with systematically altered physical properties including size, shape, and rigidity, as well as both in vitro and in vivo analyses of their performance in blood circulation, tumor penetration, cancer cell uptake, and anticancer efficacy. We also developed both data and simulation-based models for understanding the influence of physical properties, both individually and considered together, on each delivery step and overall delivery process. Thus, beyond finding that nanocarriers that are simultaneously endowed with tubular shape, short length, and low rigidity outperformed the other types, we now have a suit of theoretical models that can predict how nanocarrier properties will individually and collectively perform in the multistep delivery of anticancer therapies. |
| DOI | 10.1126/sciadv.abe2458 |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[21622608] ; National Natural Science Foundation of China[31471577] ; National Natural Science Foundation of China[31772014] ; National Natural Science Foundation of China[11422215] ; National Natural Science Foundation of China[11272327] ; National Natural Science Foundation of China[11902092] ; National Natural Science Foundation of China[11672079] ; National Key R&D Program of China[2017YFA0207900] ; Beijing Nova Program[Z181100006218071] ; Opening Fund of State Key Laboratory of Nonlinear Mechanics ; China Postdoctoral Science Foundation[2019M650602] |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| Funding Organization | National Natural Science Foundation of China ; National Key R&D Program of China ; Beijing Nova Program ; Opening Fund of State Key Laboratory of Nonlinear Mechanics ; China Postdoctoral Science Foundation |
| WOS ID | WOS:000615369000003 |
| Publisher | AMER ASSOC ADVANCEMENT SCIENCE |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/43604 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Wei, Wei; Shi, Xinghua; Li, Yuan |
| Affiliation | 1.China Agr Univ, Key Lab Precis Nutr & Food Qual, Coll Food Sci & Nutr Engn, Key Lab Funct Dairy, Beijing 100083, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Natl Ctr Nanosci & Technol, Lab Theoret & Computat Nanosci, Chinese Acad Sci CAS Key Lab Nanosyst & Hierarchy, Beijing 100190, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Bao, Weier,Tian, Falin,Lyu, Chengliang,et al. Experimental and theoretical explorations of nanocarriers' multistep delivery performance for rational design and anticancer prediction[J]. SCIENCE ADVANCES,2021,7(6):15. |
| APA | Bao, Weier.,Tian, Falin.,Lyu, Chengliang.,Liu, Bin.,Li, Bin.,...&Li, Yuan.(2021).Experimental and theoretical explorations of nanocarriers' multistep delivery performance for rational design and anticancer prediction.SCIENCE ADVANCES,7(6),15. |
| MLA | Bao, Weier,et al."Experimental and theoretical explorations of nanocarriers' multistep delivery performance for rational design and anticancer prediction".SCIENCE ADVANCES 7.6(2021):15. |
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