CAS OpenIR
Biomimetic Nanozymes Based on Coassembly of Amino Acid and Hemin for Catalytic Oxidation and Sensing of Biomolecules
Geng, Rui1; Chang, Rui2; Zou, Qianli2,3; Shen, Guizhi2,4; Jiao, Tifeng1; Yan, Xuehai2
2021-03-24
Source PublicationSMALL
ISSN1613-6810
Pages6
AbstractNanoassemblies based on self-assembly of biological building blocks are promising in mimicking the nanostructures, properties, and functionalities of natural enzymes. However, it remains a challenge to design of biomimetic nanozymes with tunable nanostructures and enhanced catalytic activities starting from simple biomolecules. Herein, the construction of nanoassemblies through coassembly of an amphiphilic amino acid and hemin is reported. The nanostructures and morphologies of the resulting nanoassemblies are readily controlled by tuning the molar ratio between the amino acid and hemin, thus leading to tailored peroxidase-mimicking activities of the nanoassemblies. Importantly, the optimized nanoassemblies exhibit a remarkable catalytic efficiency that is comparable to the natural counterpart when considering molecular mass along with good robustness in multiple catalytic cycles. The nanoassemblies are effectively integrated as biomimetic nanozymes in a sensing system for catalytic detection of glucose. Therefore, this work demonstrates that nanozymes with advanced catalytic capabilities can be constructed by self-assembly of minimalist biological building blocks and may thus promote the rational design and catalytic applications of biomimetic nanozymes.
Keywordamino acid hemin nanozymes peroxidase self‐ assembly
DOI10.1002/smll.202008114
Language英语
Funding ProjectNational Natural Science Foundation of China[22025207] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21977095] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034] ; Key Research Program of Nanjing IPE Institute of Green Manufacturing Industry[E0010722]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; Key Research Program of Nanjing IPE Institute of Green Manufacturing Industry
WOS IDWOS:000631980200001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/47976
Collection中国科学院过程工程研究所
Corresponding AuthorZou, Qianli; Jiao, Tifeng; Yan, Xuehai
Affiliation1.Yanshan Univ, Sch Environm & Chem Engn, Hebei Key Lab Appl Chem, State Key Lab Metastable Mat Sci & Technol, Qinhuangdao 066004, Hebei, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China
4.Nanjing IPE Inst Green Mfg Ind, Nanjing 211135, Peoples R China
Recommended Citation
GB/T 7714
Geng, Rui,Chang, Rui,Zou, Qianli,et al. Biomimetic Nanozymes Based on Coassembly of Amino Acid and Hemin for Catalytic Oxidation and Sensing of Biomolecules[J]. SMALL,2021:6.
APA Geng, Rui,Chang, Rui,Zou, Qianli,Shen, Guizhi,Jiao, Tifeng,&Yan, Xuehai.(2021).Biomimetic Nanozymes Based on Coassembly of Amino Acid and Hemin for Catalytic Oxidation and Sensing of Biomolecules.SMALL,6.
MLA Geng, Rui,et al."Biomimetic Nanozymes Based on Coassembly of Amino Acid and Hemin for Catalytic Oxidation and Sensing of Biomolecules".SMALL (2021):6.
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