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Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor
Gong, Changguo1; Zhang, Xiao2; Shi, Min1; Li, Feng2,3; Wang, Shuang2; Wang, Yan1,2; Wang, Yugang3; Wei, Wei2,3; Ma, Guanghui2,3
2021-03-16
Source PublicationADVANCED SCIENCE
Pages13
AbstractAs membrane-bound extracellular vesicles, exosomes have targeting ability for specific cell types, and the cellular environment strongly impacts their content and uptake efficiency. Inspired by these natural properties, the impacts of various cellular stress conditions on the uptake efficiency of tumor iterated exosomes are evaluated, and low-pH treatment caused increased uptake efficiency and retained cell-type specificity is found. Lipidomics analyses and molecular dynamics simulations reveal a glycerolipid self-aggregation-based mechanism for the enhanced homologous uptake. Furthermore, these low-pH reprogrammed exosomes are developed into a smart drug delivery platform, which is capable of specifically targeting tumor cells and selectively releasing diverse chemodrugs in response to the exosome rupture by the near-infrared irradiance-triggered burst of reactive oxygen species. This platform exerts safe and enhanced antitumor effects demonstrated by multiple model mice experiments. These results open a new avenue to reprogram exosomes for smart drug delivery and potentially personalized therapy against their homologous tumor.
Keywordcombination therapy lipids rearrangement low pH reprogramming patient‐ derived xenografts tumor exosomes
DOI10.1002/advs.202002787
Language英语
Funding ProjectInnovative Research Group Project of the National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[81871912] ; National Natural Science Foundation of China[81970530] ; National Key R&D Program of China[2017YFA0207900] ; Chinese Academy of Sciences[XDB29040303] ; Shanghai Municipal Health Bureau Key Disciplines Grant[ZK2019C012]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationInnovative Research Group Project of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; Chinese Academy of Sciences ; Shanghai Municipal Health Bureau Key Disciplines Grant
WOS IDWOS:000629229800001
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/48019
Collection中国科学院过程工程研究所
Corresponding AuthorWang, Yugang; Wei, Wei; Ma, Guanghui
Affiliation1.Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Gastroenterol, 1111 Xianxia Rd, Shanghai 200336, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 Bei Er Tiao, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, 19A Yuquan Rd, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Gong, Changguo,Zhang, Xiao,Shi, Min,et al. Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor[J]. ADVANCED SCIENCE,2021:13.
APA Gong, Changguo.,Zhang, Xiao.,Shi, Min.,Li, Feng.,Wang, Shuang.,...&Ma, Guanghui.(2021).Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor.ADVANCED SCIENCE,13.
MLA Gong, Changguo,et al."Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor".ADVANCED SCIENCE (2021):13.
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