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| Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor | |
| Gong, Changguo1; Zhang, Xiao2; Shi, Min1; Li, Feng2,3; Wang, Shuang2; Wang, Yan1,2; Wang, Yugang3; Wei, Wei2,3; Ma, Guanghui2,3 | |
| 2021-03-16 | |
| Source Publication | ADVANCED SCIENCE
 |
| Pages | 13 |
| Abstract | As membrane-bound extracellular vesicles, exosomes have targeting ability for specific cell types, and the cellular environment strongly impacts their content and uptake efficiency. Inspired by these natural properties, the impacts of various cellular stress conditions on the uptake efficiency of tumor iterated exosomes are evaluated, and low-pH treatment caused increased uptake efficiency and retained cell-type specificity is found. Lipidomics analyses and molecular dynamics simulations reveal a glycerolipid self-aggregation-based mechanism for the enhanced homologous uptake. Furthermore, these low-pH reprogrammed exosomes are developed into a smart drug delivery platform, which is capable of specifically targeting tumor cells and selectively releasing diverse chemodrugs in response to the exosome rupture by the near-infrared irradiance-triggered burst of reactive oxygen species. This platform exerts safe and enhanced antitumor effects demonstrated by multiple model mice experiments. These results open a new avenue to reprogram exosomes for smart drug delivery and potentially personalized therapy against their homologous tumor. |
| Keyword | combination therapy lipids rearrangement low pH reprogramming patient‐ derived xenografts tumor exosomes |
| DOI | 10.1002/advs.202002787 |
| Language | 英语 |
| Funding Project | Innovative Research Group Project of the National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[81871912] ; National Natural Science Foundation of China[81970530] ; National Key R&D Program of China[2017YFA0207900] ; Chinese Academy of Sciences[XDB29040303] ; Shanghai Municipal Health Bureau Key Disciplines Grant[ZK2019C012] |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS Subject | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| Funding Organization | Innovative Research Group Project of the National Natural Science Foundation of China ; National Natural Science Foundation of China ; National Key R&D Program of China ; Chinese Academy of Sciences ; Shanghai Municipal Health Bureau Key Disciplines Grant |
| WOS ID | WOS:000629229800001 |
| Publisher | WILEY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/48019 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Wang, Yugang; Wei, Wei; Ma, Guanghui |
| Affiliation | 1.Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Gastroenterol, 1111 Xianxia Rd, Shanghai 200336, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 Bei Er Tiao, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, 19A Yuquan Rd, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Gong, Changguo,Zhang, Xiao,Shi, Min,et al. Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor[J]. ADVANCED SCIENCE,2021:13. |
| APA | Gong, Changguo.,Zhang, Xiao.,Shi, Min.,Li, Feng.,Wang, Shuang.,...&Ma, Guanghui.(2021).Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor.ADVANCED SCIENCE,13. |
| MLA | Gong, Changguo,et al."Tumor Exosomes Reprogrammed by Low pH Are Efficient Targeting Vehicles for Smart Drug Delivery and Personalized Therapy against their Homologous Tumor".ADVANCED SCIENCE (2021):13. |
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