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| Near-infrared light-triggered platelet arsenal for combined photothermal-immunotherapy against cancer | |
| Lv, Yanlin1,2; Li, Feng1,3; Wang, Shuang1; Lu, Guihong1; Bao, Weier2; Wang, Yugang4; Tian, Zhiyuan2; Wei, Wei1,3; Ma, Guanghui1,3 | |
| 2021-03-01 | |
| Source Publication | SCIENCE ADVANCES
 |
| ISSN | 2375-2548 |
| Volume | 7Issue:13Pages:16 |
| Abstract | To address long-standing issues with tumor penetration and targeting among cancer therapeutics, we developed an anticancer platelet-based biomimetic formulation (N+R@PLTs), integrating photothermal nanoparticles (N) and immunostimulator (R) into platelets (PLTs). Exploiting the aggregative properties of platelets and high photothermal capacity, N+R@PLTs functioned as an arsenal by targeting defective tumor vascular endothelial cells, accumulating in a positive feedback aggregation cascade at sites of acute vascular damage induced by N-generated local hyperthermia, and subsequently secreting nanosized proplatelets (nPLTs) to transport active components to deep tumor tissue. The immunostimulator augmented the immunogenicity of antigens released from ablated tumors, inducing a stronger immunological response to attack residual, metastatic, and recurrent tumors. Following activation by low-power near-infrared light irradiation, the photothermal and immunological components synergistically provide exceptionally high therapeutic efficacy across nine murine models that mimicked a range of clinical requirements, and, most notably, a sophisticated model based on humanized mouse and patient-derived tumor xenograft. |
| DOI | 10.1126/sciadv.abd7614 |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China[21773241] ; National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[21907096] ; National Key R&D Program of China[2017YFA0207900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] |
| WOS Research Area | Science & Technology - Other Topics |
| WOS Subject | Multidisciplinary Sciences |
| Funding Organization | National Natural Science Foundation of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| WOS ID | WOS:000633443600010 |
| Publisher | AMER ASSOC ADVANCEMENT SCIENCE |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/48067 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Tian, Zhiyuan; Wei, Wei; Ma, Guanghui |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Sci, Beijing 100049, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 4.Shanghai Jiao Tong Univ, Shanghai Tongren Hosp, Sch Med, Dept Gastroenterol, Shanghai 200336, Peoples R China |
| Recommended Citation GB/T 7714 | Lv, Yanlin,Li, Feng,Wang, Shuang,et al. Near-infrared light-triggered platelet arsenal for combined photothermal-immunotherapy against cancer[J]. SCIENCE ADVANCES,2021,7(13):16. |
| APA | Lv, Yanlin.,Li, Feng.,Wang, Shuang.,Lu, Guihong.,Bao, Weier.,...&Ma, Guanghui.(2021).Near-infrared light-triggered platelet arsenal for combined photothermal-immunotherapy against cancer.SCIENCE ADVANCES,7(13),16. |
| MLA | Lv, Yanlin,et al."Near-infrared light-triggered platelet arsenal for combined photothermal-immunotherapy against cancer".SCIENCE ADVANCES 7.13(2021):16. |
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