CAS OpenIR
Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy
Li, Shukun1,3; Zhang, Wenjia2; Xing, Ruirui1; Yuan, Chengqian1; Xue, Huadan2; Yan, Xuehai1,3
2021-04-19
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Pages9
AbstractPancreatic cancer, one of the most lethal malignancies, compromises the performance of traditional therapeutic regimens in the clinic because of stromal resistance to systemic drug delivery and poor prognosis caused by tumor metastasis. Therefore, a biocompatible therapeutic paradigm that can effectively inhibit pancreatic tumor growth while simultaneously eliminating tumor metastasis is urgently needed. Herein, supramolecular nanofibrils are fabricated through coassembly of clinically approved immunomodulatory thymopentin and near-infrared indocyanine green for localized photothermal immunotherapy of pancreatic tumors. The resulting long-range ordered fibrous nanodrugs show improved photophysical capabilities for fluorescence imaging and photothermal conversion and significantly promote the proliferation and differentiation of antitumor immune cells. Hence, the integration of rapid photothermal therapy and moderate immunomodulation for inhibiting tumor growth and eliminating tumor metastasis is promising. The utilization of clinically approved molecules to construct nanodrugs administered via localized injection amplifies the complementary photothermal immunotherapeutic effects of the components, creating opportunities for clinical translation as a treatment for pancreatic cancer.
Keywordcancer peptides photosensitizers photothermal immunotherapy self‐ assembly
DOI10.1002/adma.202100595
Language英语
Funding ProjectNational Science Fund for Distinguished Young Scholars of China[22025207] ; National Natural Science Foundation of China[22072154] ; National Natural Science Fund BRICS STI Framework Program of China[51861145304] ; Innovation Research Community Science Fund of China[21821005] ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Science Fund for Distinguished Young Scholars of China ; National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Program of China ; Innovation Research Community Science Fund of China ; Key Research Program of Frontier Sciences of Chinese Academy of Sciences (CAS)
WOS IDWOS:000641165700001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/48252
Collection中国科学院过程工程研究所
Corresponding AuthorXing, Ruirui; Xue, Huadan; Yan, Xuehai
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
3.Peking Union Med Coll Hosp, Dept Radiol, State Key Lab Complex Severe & Rare Dis, Beijing 100730, Peoples R China
Recommended Citation
GB/T 7714
Li, Shukun,Zhang, Wenjia,Xing, Ruirui,et al. Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy[J]. ADVANCED MATERIALS,2021:9.
APA Li, Shukun,Zhang, Wenjia,Xing, Ruirui,Yuan, Chengqian,Xue, Huadan,&Yan, Xuehai.(2021).Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy.ADVANCED MATERIALS,9.
MLA Li, Shukun,et al."Supramolecular Nanofibrils Formed by Coassembly of Clinically Approved Drugs for Tumor Photothermal Immunotherapy".ADVANCED MATERIALS (2021):9.
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