CAS OpenIR
Metal-Free Nanoassemblies of Water-Soluble Photosensitizer and Adenosine Triphosphate for Efficient and Precise Photodynamic Cancer Therapy
Li, Zhiliang1,2; Li, Shukun3,4; Guo, Yanhui2; Yuan, Chengqian3; Yan, Xuehai3,4; Schanze, Kirk S.1
2021-03-23
Source PublicationACS NANO
ISSN1936-0851
Volume15Issue:3Pages:4979-4988
AbstractEngineering photosensitizers into stimuli-responsive supramolecular nanodrugs allows enhanced spatiotemporal delivery and controllable release of photosensitizers, which is promising for dedicated and precise tumor photodynamic therapy. Complicated fabrication for nanodrugs with good tumor accumulation capability and the undesirable side-effects caused by the drug components retards the application of PDT in vivo. The fact that extracellular adenosine triphosphate (ATP) is overexpressed in tumor tissue has been overlooked in fabricating nanomedicines for tumor-targeting delivery. Hence, herein we present metal-free helical nanofibers formed in aqueous solution from the coassembly of a cationic porphyrin and ATP as a nanodrug for PDT. The easily accessible and compatible materials and simple preparation enable the nanodrugs with potential in PDT for cancer. Compared to the cationic porphyrin alone, the porphyrin-ATP nanofibers exhibited enhanced tumor-site photosensitizer delivery through whole-body blood circulation. Overexpressed extracellular ATP stabilizes the porphyrin-ATP nanodrug within tumor tissue, giving rise to enhanced uptake of the nanodrug by cancer cells. The enzyme-triggered release of photosensitizers from the nanodrugs upon biodegradation of ATP by intracellular phosphatases results in good tumor therapeutic efficacy. This study demonstrates the potential for employing the tumor microenvironment to aid the accumulation of nanodrugs in tumors, inspiring the fabrication of smart nanomedicines.
Keywordphotodynamic therapy self-assembly tumor microenvironment nanodrugs adenosine triphosphate
DOI10.1021/acsnano.0c09913
Language英语
Funding ProjectWelch Foundation through Welch Chair at the University of Texas at San Antonio[AX-0045-20110629] ; National Natural Science Foundation of China[21522307] ; National Natural Science Foundation of China[21802143] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Innovation Research Community Science Fund[21821005] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDB-SSW-JSC034]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationWelch Foundation through Welch Chair at the University of Texas at San Antonio ; National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Innovation Research Community Science Fund ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)
WOS IDWOS:000634569100107
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/48256
Collection中国科学院过程工程研究所
Corresponding AuthorYan, Xuehai; Schanze, Kirk S.
Affiliation1.Univ Texas San Antonio, Dept Chem, San Antonio, TX 78249 USA
2.Shandong Univ, Inst Mol Sci & Engn, Inst Frontier & Interdisciplinary Sci, Qingdao 266237, Shandong, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Zhiliang,Li, Shukun,Guo, Yanhui,et al. Metal-Free Nanoassemblies of Water-Soluble Photosensitizer and Adenosine Triphosphate for Efficient and Precise Photodynamic Cancer Therapy[J]. ACS NANO,2021,15(3):4979-4988.
APA Li, Zhiliang,Li, Shukun,Guo, Yanhui,Yuan, Chengqian,Yan, Xuehai,&Schanze, Kirk S..(2021).Metal-Free Nanoassemblies of Water-Soluble Photosensitizer and Adenosine Triphosphate for Efficient and Precise Photodynamic Cancer Therapy.ACS NANO,15(3),4979-4988.
MLA Li, Zhiliang,et al."Metal-Free Nanoassemblies of Water-Soluble Photosensitizer and Adenosine Triphosphate for Efficient and Precise Photodynamic Cancer Therapy".ACS NANO 15.3(2021):4979-4988.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Li, Zhiliang]'s Articles
[Li, Shukun]'s Articles
[Guo, Yanhui]'s Articles
Baidu academic
Similar articles in Baidu academic
[Li, Zhiliang]'s Articles
[Li, Shukun]'s Articles
[Guo, Yanhui]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Li, Zhiliang]'s Articles
[Li, Shukun]'s Articles
[Guo, Yanhui]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.