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Facile green synthesis of copper oxide nanoparticles for the eradication of multidrug resistant Klebsiella pneumonia and Helicobacter pylori biofilms
Naseer, Minha1; Ramadan, Rana2,3,4; Xing, Jianmin2,3,4; Samak, Nadia A.2,3,4,5
2021-04-01
Source PublicationINTERNATIONAL BIODETERIORATION & BIODEGRADATION
ISSN0964-8305
Volume159Pages:8
AbstractIn the present study, copper oxide nanoparticles (CuO NPs) were successfully synthesized from Cassia fistula and Melia azedarach leaf extracts via cupric nitrate approach. The successful biosynthesis of CuO NPs was confirmed by experimental analysis such as color transformation, ultraviolet light spectroscopy (UV-spectroscopy), Fourier transform infrared spectroscopy (FTIR), X-ray diffraction analysis (XRD), dynamic light scattering (DLS) and scanning electron microscopy (SEM). Antibacterial activity of the biosynthesized CuO NPs was confirmed against the two antibiotic resistant clinical strains of Klebsiella pneumonia and Helicobacter pylori. Well diffusion assay and minimum inhibitory concentration (MIC) values were optimum when 1 ?g/ml of the NPs were used. This concentration of the NPs derived from C. fistula inhibited the biofilm formation of K. pneumonia and H. pylori by 99.8% and 100%, respectively. On the other hand, the NPs derived from M. azadarech showed biofilm formation inhibition by 92.5% and 99.5% for K. pneumonia and H. pylori, respectively. Scanning electron microscopy (SEM) further elucidated the antibacterial effect through bacterial cell shape disruption and DNA damage.
KeywordCuO NPs Green synthesis C fistula M azedarach
DOI10.1016/j.ibiod.2021.105201
Language英语
WOS Research AreaBiotechnology & Applied Microbiology ; Environmental Sciences & Ecology
WOS SubjectBiotechnology & Applied Microbiology ; Environmental Sciences
WOS IDWOS:000636783600002
PublisherELSEVIER SCI LTD
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/48315
Collection中国科学院过程工程研究所
Corresponding AuthorSamak, Nadia A.
Affiliation1.Int Islamic Univ Islamabad, Dept Environm Sci, Islamabad, Pakistan
2.Chinese Acad Sci, Inst Proc Engn, CAS Key Lab Green Proc & Engn, 1 Zhongguancun Bei Er Tiao, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 Zhongguancun Bei Er Tiao, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Coll Chem Engn, 19 A Yuquan Rd, Beijing 100049, Peoples R China
5.Egyptian Petr Res Inst, Proc Design & Dev Dept, Cairo 11727, Egypt
Recommended Citation
GB/T 7714
Naseer, Minha,Ramadan, Rana,Xing, Jianmin,et al. Facile green synthesis of copper oxide nanoparticles for the eradication of multidrug resistant Klebsiella pneumonia and Helicobacter pylori biofilms[J]. INTERNATIONAL BIODETERIORATION & BIODEGRADATION,2021,159:8.
APA Naseer, Minha,Ramadan, Rana,Xing, Jianmin,&Samak, Nadia A..(2021).Facile green synthesis of copper oxide nanoparticles for the eradication of multidrug resistant Klebsiella pneumonia and Helicobacter pylori biofilms.INTERNATIONAL BIODETERIORATION & BIODEGRADATION,159,8.
MLA Naseer, Minha,et al."Facile green synthesis of copper oxide nanoparticles for the eradication of multidrug resistant Klebsiella pneumonia and Helicobacter pylori biofilms".INTERNATIONAL BIODETERIORATION & BIODEGRADATION 159(2021):8.
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