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| Two-dimensional layered double hydroxide nanoadjuvant: recent progress and future direction | |
| Zhang, Ling-Xiao1,2,3,7; Hu, Jing4,5; Jia, Ying-Bo5,6; Liu, Rui-Tian6; Cai, Ting1,2; Xu, Zhi Ping3 | |
| 2021-04-01 | |
| Source Publication | NANOSCALE
 |
| ISSN | 2040-3364 |
| Pages | 17 |
| Abstract | Layered double hydroxide (LDH) is a 'sandwich'-like two-dimensional clay material that has been systematically investigated for biomedical application in the past two decades. LDH is an alum-similar adjuvant, which has a well-defined layered crystal structure and exhibits high adjuvanticity. The unique structure of LDH includes positively charged layers composed of divalent and trivalent cations and anion-exchangeable interlayer galleries. Among the many variants of LDH, MgAl-LDH (the cationic ions are Mg2+ and Al3+) has the highest affinity to antigens, bioadjuvants and drug molecules, and exhibits superior biosafety. Past research studies indicate that MgAl-LDH can simultaneously load antigens, bioadjuvants and molecular drugs to amplify the strength of immune responses, and induce broad-spectrum immune responses. Moreover, the size and dispersity of MgAl-LDH in biological environments can be well controlled to actively deliver antigens to the immune system, realizing the rapid induction and maintenance of durable immune responses. Furthermore, the functionalization of MgAl-LDH nanoadjuvants enables it to capture antigens in situ and induce personalized immune responses, thereby more effectively overcoming complex diseases. In this review, we comprehensively summarize the development and application of MgAl-LDH nanoparticles as a vaccine adjuvant, demonstrating that MgAl-LDH is the most potential adjuvant for clinical application. |
| DOI | 10.1039/d1nr00881a |
| Language | 英语 |
| Funding Project | Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences[2020YJY0222] ; Australian Research Council (ARC) Discovery Project[DP190103486] ; International Partnership Program of Chinese Academy of Sciences[122111KYSB20180005] ; Zhejiang Provincial Natural Science Foundation of China[LY19H160011] ; Ningbo Digestive System Clinical Medicine Research Center[2019A21003] |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS Subject | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| Funding Organization | Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences ; Australian Research Council (ARC) Discovery Project ; International Partnership Program of Chinese Academy of Sciences ; Zhejiang Provincial Natural Science Foundation of China ; Ningbo Digestive System Clinical Medicine Research Center |
| WOS ID | WOS:000641435500001 |
| Publisher | ROYAL SOC CHEMISTRY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/48416 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Zhang, Ling-Xiao; Cai, Ting; Xu, Zhi Ping |
| Affiliation | 1.Univ Chinese Acad Sci, Hwa Mei Hosp, Ningbo Hosp 2, Ningbo 315010, Peoples R China 2.Univ Chinese Acad Sci, Ningbo Inst Life & Hlth Ind, Ningbo 315010, Peoples R China 3.Univ Queensland, Australian Inst Bioengn & Nanotechnol, St Lucia, Qld 4072, Australia 4.Chinese Acad Sci, Dalian Inst Chem Phys, Dalian 116023, Peoples R China 5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 6.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 7.Zhejiang Univ, Coll Pharmaceut Sci, Inst Pharmaceut, Hangzhou 310058, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Ling-Xiao,Hu, Jing,Jia, Ying-Bo,et al. Two-dimensional layered double hydroxide nanoadjuvant: recent progress and future direction[J]. NANOSCALE,2021:17. |
| APA | Zhang, Ling-Xiao,Hu, Jing,Jia, Ying-Bo,Liu, Rui-Tian,Cai, Ting,&Xu, Zhi Ping.(2021).Two-dimensional layered double hydroxide nanoadjuvant: recent progress and future direction.NANOSCALE,17. |
| MLA | Zhang, Ling-Xiao,et al."Two-dimensional layered double hydroxide nanoadjuvant: recent progress and future direction".NANOSCALE (2021):17. |
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