Knowledge Management System Of Institute of process engineering,CAS
| Exploring Effects of Chitosan Oligosaccharides on the DSS-Induced Intestinal Barrier Impairment In Vitro and In Vivo | |
| Wang, Yujie1,2; Wen, Rong1,3; Liu, Dongdong1; Zhang, Chen1; Wang, Zhuo A.1; Du, Yuguang1 | |
| 2021-04-01 | |
| Source Publication | MOLECULES
 |
| Volume | 26Issue:8Pages:16 |
| Abstract | Intestinal barrier dysfunction is an essential pathological change in inflammatory bowel disease (IBD). The mucus layer and the intestinal epithelial tight junction act together to maintain barrier integrity. Studies showed that chitosan oligosaccharide (COS) had a positive effect on gut health, effectively protecting the intestinal barrier in IBD. However, these studies usually focused on its impact on the intestinal epithelial tight junction. The influence of COS on the intestinal mucus layer is still poorly understood. In this study, we explored the effect of COS on intestinal mucus in vitro using human colonic mucus-secreted HT-29 cells. COS relieved DSS (dextran sulfate sodium)-induced mucus defects. Additionally, the structural characteristics of COS greatly influenced this activity. Finally, we evaluated the protective effect of COS on intestinal barrier function in mice with DSS-induced colitis. The results indicated that COS could manipulate intestinal mucus production, which likely contributed to its intestinal protective effects. |
| Keyword | chitosan oligosaccharide intestinal barrier mucus intestinal tight junction inflammatory bowel disease |
| DOI | 10.3390/molecules26082199 |
| Language | 英语 |
| Funding Project | National Key Research and Development Program of China[2019YFD0902000] ; National Natural Science Foundation of China[31870802] |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry |
| WOS Subject | Biochemistry & Molecular Biology ; Chemistry, Multidisciplinary |
| Funding Organization | National Key Research and Development Program of China ; National Natural Science Foundation of China |
| WOS ID | WOS:000644618500001 |
| Publisher | MDPI |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/48480 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Wang, Zhuo A.; Du, Yuguang |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 3.Sichuan Normal Univ, Coll Life Sci, Chengdu 610101, Peoples R China |
| Recommended Citation GB/T 7714 | Wang, Yujie,Wen, Rong,Liu, Dongdong,et al. Exploring Effects of Chitosan Oligosaccharides on the DSS-Induced Intestinal Barrier Impairment In Vitro and In Vivo[J]. MOLECULES,2021,26(8):16. |
| APA | Wang, Yujie,Wen, Rong,Liu, Dongdong,Zhang, Chen,Wang, Zhuo A.,&Du, Yuguang.(2021).Exploring Effects of Chitosan Oligosaccharides on the DSS-Induced Intestinal Barrier Impairment In Vitro and In Vivo.MOLECULES,26(8),16. |
| MLA | Wang, Yujie,et al."Exploring Effects of Chitosan Oligosaccharides on the DSS-Induced Intestinal Barrier Impairment In Vitro and In Vivo".MOLECULES 26.8(2021):16. |
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