Knowledge Management System Of Institute of process engineering,CAS
| Micro- and Nanoencapsulated Hybrid Delivery System (MNEHDS): A Novel Approach for Colon-Targeted Oral Delivery of Berberine | |
| Zhang, Lingzhi1,2; Li, Mingyan1,2; Zhang, Guiqiu1,2; Gao, Changxing1,2; Wang, Shengfang3,4; Zhang, Tingting1,2; Ma, Chen1,2; Wang, Lianyan3; Zhu, Qing1,2 | |
| 2021-04-05 | |
| Source Publication | MOLECULAR PHARMACEUTICS
 |
| ISSN | 1543-8384 |
| Volume | 18Issue:4Pages:1573-1581 |
| Abstract | Berberine (BBR) is currently explored in the oral treatment of many disorders, especially in those involving inflammatory processes. Nanotechnology-based drug delivery systems are emerging as an effective approach for improving the poor oral absorption/bioavailability of BBR. To optimize the BBR immunoregulatory effects on a specific part of the gastrointestinal tract, here we describe a micro- and nanoencapsulated hybrid delivery system (MNEHDS) for colon-targeted oral delivery of BBR and test its therapeutic efficacy in a murine colitis model. The MNEHDS is formed by encapsulation of BBR-loaded poly(lactic-co-glycolic acid) nanoparticles into a pH-sensitive, BBR-pre-entrapped Eudragit FS30D matrix to form a hybrid microparticle composed of the BBR and BBR nanoparticles. Once in the colonic environment, the microencapsulated BBR is almost completely released for immediate action, while BBR nanoparticles can provide sustained release of BBR subsequent to their intestinal absorption. One dose of oral MNEHDS/BBR treatment results in significant attenuation of acute colitis induced by dextran sulfate sodium. The MNEHDS/BBR also proves to be effective during chronically induced colitis with two doses given 1 week apart. The improved efficacy is accompanied by decreased production of colon inflammation. Comparatively, oral treatment with one or two 7-day courses of free BBR has less effect on ameliorating either acute or chronic colitis. Thus, MNEHDS represents a novel delivery system for BBR, and potentially other therapeutic agents, to treat inflammatory bowel disease. |
| Keyword | berberine microencapsulation nanoencapsulation nanoparticle controlled release Eudragit dextran sulfate sodium-induced colitis drug delivery system |
| DOI | 10.1021/acs.molpharmaceut.0c00970 |
| Language | 英语 |
| Funding Project | National Natural Science Foundation of China, China[31370922] ; National Natural Science Foundation of China, China[81973262] ; Beijing Natural Science Foundation, China[5131002] ; CAMS Major Collaborative Innovation Project, China[2016-12M-1-011] ; National Science and Technology Major Project of China[2016ZX10004001-005] |
| WOS Research Area | Research & Experimental Medicine ; Pharmacology & Pharmacy |
| WOS Subject | Medicine, Research & Experimental ; Pharmacology & Pharmacy |
| Funding Organization | National Natural Science Foundation of China, China ; Beijing Natural Science Foundation, China ; CAMS Major Collaborative Innovation Project, China ; National Science and Technology Major Project of China |
| WOS ID | WOS:000637870700007 |
| Publisher | AMER CHEMICAL SOC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/48518 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Wang, Lianyan; Zhu, Qing |
| Affiliation | 1.Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, State Key Lab Bioact Subst & Funct Nat Med, Beijing 100050, Peoples R China 2.Chinese Acad Med Sci & Peking Union Med Coll, Inst Mat Med, Beijing Key Lab New Drug Mech & Pharmacol Evaluat, Beijing 100050, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 4.Northeast Forestry Univ, Coll Chem Chem Engn & Resource Utilizat, Harbin 150040, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Lingzhi,Li, Mingyan,Zhang, Guiqiu,et al. Micro- and Nanoencapsulated Hybrid Delivery System (MNEHDS): A Novel Approach for Colon-Targeted Oral Delivery of Berberine[J]. MOLECULAR PHARMACEUTICS,2021,18(4):1573-1581. |
| APA | Zhang, Lingzhi.,Li, Mingyan.,Zhang, Guiqiu.,Gao, Changxing.,Wang, Shengfang.,...&Zhu, Qing.(2021).Micro- and Nanoencapsulated Hybrid Delivery System (MNEHDS): A Novel Approach for Colon-Targeted Oral Delivery of Berberine.MOLECULAR PHARMACEUTICS,18(4),1573-1581. |
| MLA | Zhang, Lingzhi,et al."Micro- and Nanoencapsulated Hybrid Delivery System (MNEHDS): A Novel Approach for Colon-Targeted Oral Delivery of Berberine".MOLECULAR PHARMACEUTICS 18.4(2021):1573-1581. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment