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Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard'' for synergistic treatment of synucleinopathies
Ji, Weihong1,2; Li, Yan1; Liu, Ruiyuan1,2; Lu, Zhiguo1,2; Liu, Linying1,2; Shi, Zhuyan1,2; Shen, Jie1,2; Zhang, Xin1
2021-04-01
Source PublicationMATERIALS HORIZONS
ISSN2051-6347
Volume8Issue:4Pages:1199-1206
AbstractSynaptic vesicle-inspired nanoparticles (RT-PPB NPs) as a "nanoguard'' were designed for clearing the toxic a-synuclein aggregates in diseased neurons and preventing the culprits from escaping to affect other normal cells. The NPs could overcome a series of tissue and cellular barriers and controllably release drugs in the diseased neurons, which ensured the optimization of synergistic treatment. This study indicates that the synaptic vesicle-inspired NPs may have the potential to open up a new avenue for the treatment of synucleinopathies, as well as other neurodegenerative diseases.
DOI10.1039/d0mh01542c
Language英语
Funding ProjectBeijing Natural Science Foundation[L172046] ; Beijing Natural Science Foundation[2192057] ; National High Technology Research and Development Program[2016YFA0200303] ; National Natural Science Foundation of China[21905283] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; Beijing Nova Program[Z201100006820140]
WOS Research AreaChemistry ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Materials Science, Multidisciplinary
Funding OrganizationBeijing Natural Science Foundation ; National High Technology Research and Development Program ; National Natural Science Foundation of China ; Beijing Nova Program
WOS IDWOS:000639328100022
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/48545
Collection中国科学院过程工程研究所
Corresponding AuthorZhang, Xin
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Ji, Weihong,Li, Yan,Liu, Ruiyuan,et al. Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard'' for synergistic treatment of synucleinopathies[J]. MATERIALS HORIZONS,2021,8(4):1199-1206.
APA Ji, Weihong.,Li, Yan.,Liu, Ruiyuan.,Lu, Zhiguo.,Liu, Linying.,...&Zhang, Xin.(2021).Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard'' for synergistic treatment of synucleinopathies.MATERIALS HORIZONS,8(4),1199-1206.
MLA Ji, Weihong,et al."Synaptic vesicle-inspired nanoparticles with spatiotemporally controlled release ability as a "nanoguard'' for synergistic treatment of synucleinopathies".MATERIALS HORIZONS 8.4(2021):1199-1206.
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