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Effect of acrylic acid weight percentage on the pore size in poly(N-Isopropyl acrylamide-co-acrylic acid) microspheres
Si, Tianbao1,2; Wang, Yuxia1; Wei, Wei1,2; Lv, Piping1,2; Ma, Guanghui1; Su, Zhiguo1; Wang, YX
2011-07-01
Source PublicationREACTIVE & FUNCTIONAL POLYMERS
ISSN1381-5148
Volume71Issue:7Pages:728-735
AbstractIn this article, a simple way to control pore size in monodispersed poly(N-Isopropyl acrylamide-co-acrylic acid) [P(NIPAM-co-AAc)] microspheres just by changing the acrylic acid wt.% in the formula was developed. The monodispersed P(NIPAM-co-AAc) microspheres with functionalized carboxyl groups were successfully prepared by Shirasu porous glass (SPG) membrane emulsification technique at room temperature. The microspheres were dried by supercritical drying (SCD), lyophilization and vacuum drying, separately. It was observed that SCD was an effective drying method to maintain the morphologies of the microspheres. Scanning electron microscopy (SEM), confocal laser scanning microscope (CLSM), and porosity analyzer results showed that the P(NIPAM-co-AAc) microspheres contained abundant slit-like mesoporous structure with pore size from 2 nm to 50 nm. The increase of AAc wt.% would increase the percentage of mesopores and micropores in the microspheres. P(NIPAM-co-AAc) microspheres with specific pore size can be obtained by simply changing the acrylic acid wt.% in the formula. Such temperature-/pH-sensitive microspheres with controllable pore size were expected to meet various requirements in different bioapplications, such as drug delivery and enzyme immobilization. (C) 2011 Elsevier Ltd. All rights reserved.
Keywordp(Nipam-co-aac) Microsphere Pore Size Membrane Emulsification Supercritical Drying Phase Separation
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1016/j.reactfunctpolym.2011.04.003
Indexed BySCI
Language英语
WOS KeywordN-ISOPROPYLACRYLAMIDE ; SURFACE-AREA ; DRUG-DELIVERY ; HEAVY-METAL ; HYDROGEL ; SEPARATION ; NETWORKS ; RELEASE ; DESIGN ; CHROMATOGRAPHY
WOS Research AreaChemistry ; Engineering ; Polymer Science
WOS SubjectChemistry, Applied ; Engineering, Chemical ; Polymer Science
WOS IDWOS:000292126500007
Citation statistics
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/4863
Collection生化工程国家重点实验室
Corresponding AuthorWang, YX
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Si, Tianbao,Wang, Yuxia,Wei, Wei,et al. Effect of acrylic acid weight percentage on the pore size in poly(N-Isopropyl acrylamide-co-acrylic acid) microspheres[J]. REACTIVE & FUNCTIONAL POLYMERS,2011,71(7):728-735.
APA Si, Tianbao.,Wang, Yuxia.,Wei, Wei.,Lv, Piping.,Ma, Guanghui.,...&Wang, YX.(2011).Effect of acrylic acid weight percentage on the pore size in poly(N-Isopropyl acrylamide-co-acrylic acid) microspheres.REACTIVE & FUNCTIONAL POLYMERS,71(7),728-735.
MLA Si, Tianbao,et al."Effect of acrylic acid weight percentage on the pore size in poly(N-Isopropyl acrylamide-co-acrylic acid) microspheres".REACTIVE & FUNCTIONAL POLYMERS 71.7(2011):728-735.
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