CAS OpenIR
A Diradicaloid Small Molecular Nanotheranostic with Strong Near-Infrared Absorbance for Effective Cancer Photoacoustic Imaging and Photothermal Therapy
Li, Xiaozhen1; Zhang, Di2,3; Yin, Chao4,5; Lu, Guihong6; Wan, Yingpeng1; Huang, Zhongming1; Tan, Jihua1; Li, Shengliang1,7; Luo, Jingdong2,3; Lee, Chun-Sing1
2021-04-14
Source PublicationACS APPLIED MATERIALS & INTERFACES
ISSN1944-8244
Volume13Issue:14Pages:15983-15991
Abstract

Organic small molecule-based phototheranostics hold great promise for clinical translation by virtue of their distinct chemical structure, easy reproducibility, and high purity. However, reported molecular agents typically have relatively low optical absorbances, particularly over the near-infrared (NIR) region, and this limits their phototheranostic performance. Herein, we first exploit a diradicaloid molecular structure for enhancing NIR absorption to facilitate efficient photoacoustic imaging (PAI)-guided photothermal therapy (PTT). The donor-acceptor interaction in the diradicaloid molecule (DRM) leads to strong charge transfer resulting on obvious diradical characteristics, which is beneficial for NIR absorption. The DRM possesses excellent light-harvesting ability, with a mass extinction coefficient of similar to 220 L g(-1) cm(-1), which is much higher than those (similar to 5-100 L g(-1) cm(-1)) of typical organic molecules. After assembling into nanoparticles, they show good water dispersibility, good photostability, and impressive performance for PAI-guided PTT in vitro and in vivo. The impressive in vitro and in vivo performances show that developing small molecules with diradicaloid structures can be an effective approach for enhancing NIR harvesting capability for biomedical applications.

KeywordDiradical Near-infrared Small Molecule Photoacoustic Imaging Photothermal Therapy
DOI10.1021/acsami.0c21889
Language英语
WOS KeywordSemiconducting Polymer Nanoparticles ; Nanomaterials ; Energy ; Dots
Funding ProjectARG-CityU Applied Research Grant[9667160] ; ARG-CityU Applied Research Grant[9667179] ; University Grants Committee/Research Grants Council of the Hong Kong Special Administrative Region, China[JLFS/P-101/18] ; Natural Science Foundation of China[21975213] ; Natural Science Foundation of China[62005127] ; Shenzhen Science & Technology Innovation Committee[JCYJ20180507181718203] ; General Research Fund of HKSAR (RGC)[11306320] ; City University of Hong Kong[9610389] ; City University of Hong Kong[9610454] ; City University of Hong Kong[9680263] ; National Natural Science Foundation of China[32000988] ; China Postdoctoral Science Foundation[2019TQ0212] ; China Postdoctoral Science Foundation[2020M672832] ; Nanjing University of Posts & Telecommunications[NY220068]
WOS Research AreaScience & Technology - Other Topics ; Materials Science
WOS SubjectNanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationARG-CityU Applied Research Grant ; University Grants Committee/Research Grants Council of the Hong Kong Special Administrative Region, China ; Natural Science Foundation of China ; Shenzhen Science & Technology Innovation Committee ; General Research Fund of HKSAR (RGC) ; City University of Hong Kong ; National Natural Science Foundation of China ; China Postdoctoral Science Foundation ; Nanjing University of Posts & Telecommunications
WOS IDWOS:000641156600003
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/48689
Collection中国科学院过程工程研究所
Corresponding AuthorLu, Guihong; Li, Shengliang; Luo, Jingdong; Lee, Chun-Sing
Affiliation1.City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Dept Chem, Kowloon, Hong Kong, Peoples R China
2.City Univ Hong Kong, Dept Chem, Kowloon, Hong Kong, Peoples R China
3.City Univ Hong Kong, Shenzhen Res Inst, Kowloon, Hong Kong, Peoples R China
4.Nanjing Univ Posts & Telecommun, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat IAM, Key Lab Organ Elect & Informat Displays, Nanjing 210023, Peoples R China
5.Nanjing Univ Posts & Telecommun, Jiangsu Natl Synerget Innovat Ctr Adv Mat SICAM, Inst Adv Mat IAM, Jiangsu Key Lab Biosensors, Nanjing 210023, Peoples R China
6.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
7.Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China
Recommended Citation
GB/T 7714
Li, Xiaozhen,Zhang, Di,Yin, Chao,et al. A Diradicaloid Small Molecular Nanotheranostic with Strong Near-Infrared Absorbance for Effective Cancer Photoacoustic Imaging and Photothermal Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2021,13(14):15983-15991.
APA Li, Xiaozhen.,Zhang, Di.,Yin, Chao.,Lu, Guihong.,Wan, Yingpeng.,...&Lee, Chun-Sing.(2021).A Diradicaloid Small Molecular Nanotheranostic with Strong Near-Infrared Absorbance for Effective Cancer Photoacoustic Imaging and Photothermal Therapy.ACS APPLIED MATERIALS & INTERFACES,13(14),15983-15991.
MLA Li, Xiaozhen,et al."A Diradicaloid Small Molecular Nanotheranostic with Strong Near-Infrared Absorbance for Effective Cancer Photoacoustic Imaging and Photothermal Therapy".ACS APPLIED MATERIALS & INTERFACES 13.14(2021):15983-15991.
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