CAS OpenIR
Engineering the Deformability of Albumin-Stabilized Emulsions for Lymph-Node Vaccine Delivery
Song, Tiantian1,2; Xia, Yufei2,3,4; Du, Yiqun2,5; Chen, Michael W.6; Qing, Hong1; Ma, Guanghui2,3,4
2021-05-19
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Pages10
AbstractA major challenge in vaccine delivery is to achieve robust lymph-node (LN) accumulation, which can capitalize on concentrated immunocytes and cytokines in LNs to stimulate the onset and persistence of adaptive immune responses. Previous attempts at developing vaccine delivery systems have focused on the sizes, charges, or surface ligands but not on their deformability. In fact, the LN homing of antigen-presenting cells depends on deformability to pass through the cellular gaps. Herein, the deformability of albumin-stabilized emulsions is engineered. Owing to self-adaptive deformability, the droplets (approximate to 330 nm) can attach to and deform between cells and adjust their sizes to pass through the endothelial gaps (20-100 nm), favoring direct LN transfer (intercellular pathway). Additionally, owing to relatively large sizes, some emulsions can be retained at the administration sites for potent antigen uptake and activation of APCs as well as LN-targeted delivery of vaccines (intracellular pathway). Compared with solid particles, the dual LN transfer strategy evidently enhances antigen accumulation and activation of LN drainage, potently stimulates cellular immune responses, and increases the survival rate of tumor-bearing mice. Thus, the deformability of albumin-stabilized droplets may offer an efficient strategy for potent LN targeting and enhanced vaccinations.
Keywordalbumin‐ stabilized emulsions deformability lymph node targeting vaccines vaccine delivery systems
DOI10.1002/adma.202100106
Language英语
WOS KeywordCELL TRAFFICKING ; IN-VIVO ; NANOPARTICLE ; ADJUVANT ; IMPROVE ; SYSTEM
Funding ProjectFoundation for Innovative Research Groups of the National Natural Science Foundation of China[21821005] ; Pilot Project of Chinese Academy of Sciences[XDB29040303] ; "From 0 to 1" Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences[2020000071] ; Youth Project of National Natural Science Foundation of China[21908229] ; Beijing Nova Program of Beijing Municipal Science & Technology Commission[Z201100006820139] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2020000053] ; National Science and Technology Major Project of China[2018ZX10301-103-003] ; Key External Cooperation Program of Chinese Academy of Sciences[122111KYSB20180021] ; Regulations for the Care and Use of Laboratory Animals and Guideline for Ethical Review of Animal (China)[GB/T35892-2018]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationFoundation for Innovative Research Groups of the National Natural Science Foundation of China ; Pilot Project of Chinese Academy of Sciences ; "From 0 to 1" Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences ; Youth Project of National Natural Science Foundation of China ; Beijing Nova Program of Beijing Municipal Science & Technology Commission ; Youth Innovation Promotion Association of the Chinese Academy of Sciences ; National Science and Technology Major Project of China ; Key External Cooperation Program of Chinese Academy of Sciences ; Regulations for the Care and Use of Laboratory Animals and Guideline for Ethical Review of Animal (China)
WOS IDWOS:000652105200001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/48717
Collection中国科学院过程工程研究所
Corresponding AuthorXia, Yufei; Qing, Hong; Ma, Guanghui
Affiliation1.Beijing Inst Technol, Sch Life Sci, Key Lab Mol Med & Biotherapy, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Chinese Acad Sci, Innovat Acad Green Mfg, Beijing 100190, Peoples R China
5.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Inst Translat Med, Shenzhen 518035, Peoples R China
6.Tsinghua Univ, Sch Med, Dept Biomed Engn, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Song, Tiantian,Xia, Yufei,Du, Yiqun,et al. Engineering the Deformability of Albumin-Stabilized Emulsions for Lymph-Node Vaccine Delivery[J]. ADVANCED MATERIALS,2021:10.
APA Song, Tiantian,Xia, Yufei,Du, Yiqun,Chen, Michael W.,Qing, Hong,&Ma, Guanghui.(2021).Engineering the Deformability of Albumin-Stabilized Emulsions for Lymph-Node Vaccine Delivery.ADVANCED MATERIALS,10.
MLA Song, Tiantian,et al."Engineering the Deformability of Albumin-Stabilized Emulsions for Lymph-Node Vaccine Delivery".ADVANCED MATERIALS (2021):10.
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