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Endophytes: the novel sources for plant terpenoid biosynthesis
Chen, Yachao1; Hu, Bing1; Xing, Jianmin2,3; Li, Chun4
2021-05-28
Source PublicationAPPLIED MICROBIOLOGY AND BIOTECHNOLOGY
ISSN0175-7598
Pages13
AbstractTerpenoids are natural compounds predominantly present in plants. They have many pharmaceutical and/or nutritional functions, and have been widely applied in medical, food, and cosmetics industries. Recently, terpenoids have been used in the clinical treatment of COVID-19 due to the good antiviral activities. The increasing demand for terpenoids in international markets poses a serious threat to many plant species. For environmentally sustainable development, microbial cell factories have been utilized as the promising platform to produce terpenoids. Nevertheless, the bioproduction of most terpenoids cannot meet commercial requirements due to the low cost-benefit ratio until now. The biosynthetic potential of endophytes has gained attention in recent decades owing to the continual discovery of endophytes capable of synthesizing plant bioactive compounds. Accordingly, endophytes could be alternative sources of terpenoid-producing strains or terpenoid synthetic genes. In this review, we summarized the research progress describing the main and supporting roles of endophytes in terpenoid biosynthesis and biotransformation, and discussed the current problems and challenges which may prevent the further exploitation. This review will improve our understanding of endophyte resources for terpenoid production in industry in the future.
KeywordEndophyte Terpenoid Biosynthesis Biotransformation Microbial cell factory
DOI10.1007/s00253-021-11350-7
Language英语
WOS KeywordSPACE-TIME DYNAMICS ; SYNTHETIC BIOLOGY ; HUPERZIA-SERRATA ; LYSINE DECARBOXYLASE ; FUNCTIONAL-ANALYSIS ; ENHANCED PRODUCTION ; PANAX-NOTOGINSENG ; TAXUS-CHINENSIS ; TANSHINONE IIA ; URSOLIC ACID
Funding ProjectNational Key Research and Development Program of China[2018YFA0901800] ; National Key Research and Development Program of China[2020YFA0908300] ; National Natural Science Foundation of China[21736002] ; Open Funding Project of the State Key Laboratory of Biochemical Engineering[2020KF-05]
WOS Research AreaBiotechnology & Applied Microbiology
WOS SubjectBiotechnology & Applied Microbiology
Funding OrganizationNational Key Research and Development Program of China ; National Natural Science Foundation of China ; Open Funding Project of the State Key Laboratory of Biochemical Engineering
WOS IDWOS:000655825900001
PublisherSPRINGER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/48855
Collection中国科学院过程工程研究所
Corresponding AuthorHu, Bing; Li, Chun
Affiliation1.Beijing Inst Technol, Inst Biochem Engn, Key Lab Med Mol Sci & Pharmaceut Engn, Sch Chem & Chem Engn,Minist Ind & Informat Techno, Beijing 100081, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Tsinghua Univ, Dept Chem Engn, Key Lab Ind Biocatalysis, Minist Educ, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Chen, Yachao,Hu, Bing,Xing, Jianmin,et al. Endophytes: the novel sources for plant terpenoid biosynthesis[J]. APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,2021:13.
APA Chen, Yachao,Hu, Bing,Xing, Jianmin,&Li, Chun.(2021).Endophytes: the novel sources for plant terpenoid biosynthesis.APPLIED MICROBIOLOGY AND BIOTECHNOLOGY,13.
MLA Chen, Yachao,et al."Endophytes: the novel sources for plant terpenoid biosynthesis".APPLIED MICROBIOLOGY AND BIOTECHNOLOGY (2021):13.
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