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Traceable Nano-Biohybrid Complexes by One-Step Synthesis as CRISPR-Chem Vectors for Neurodegenerative Diseases Synergistic Treatment
Shen, Jie1,2; Lu, Zhiguo1,2; Wang, Jianze1; Hao, Qiulian1; Ji, Weihong1,2; Wu, Yanyue1,2; Peng, Huan1,2; Zhao, Ruichen1,2; Yang, Jun1; Li, Yan1; Shi, Zhuyan1,2; Zhang, Xin1
2021-05-28
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Pages10
AbstractAbnormal protein aggregations are essential pathological features of neurodegenerative diseases. Eliminating while inhibiting the regeneration of these protein aggregates is considered an effective treatment strategy. Herein, the CRISPR/Cas9 gene-editing tool is employed to inhibit the regeneration of disease-related proteins, while chemical drugs are applied to eliminate the proteins that are produced. To efficiently deliver CRISPR-chem drugs into brain lesions, traceable nano-biohybrid complexes (F-TBIO) are constructed by one-step synthesis and CRISPR/Cas9 plasmids (CF-TBIO) are loaded in a controllable manner. CF-TBIO can knock out the BACE1 gene and reduce the burden of amyloid-beta, and thereby significantly improve the cognitive abilities of 2xTg-AD mice. In particular, by prolonging the dosing interval, the pathological damage and behavioral abilities of 2xTg-AD mice are still significantly improved. During the therapeutic process, CF-TBIO with a high relaxation rate provides accurate imaging signals in the complex brain physiological environment. The finding shows that CF-TBIO has great potential to serve as a CRISPR-chem drug-delivery platform for neurodegenerative diseases therapy.
KeywordCRISPR Cas9 CRISPR‐ chem vectors neurodegenerative diseases synergistic treatment one‐ step synthesis traceable nano‐ biohybrid complexes
DOI10.1002/adma.202101993
Language英语
WOS KeywordSMALL INTERFERING RNA ; ALZHEIMERS-DISEASE ; DELIVERY ; BETA ; BACE1
Funding ProjectNational Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[21905283] ; National Natural Science Foundation of China[22075289] ; National Natural Science Foundation of China[32071391] ; Beijing Natural Science Foundation[L172046] ; Beijing Natural Science Foundation[2192057]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Natural Science Foundation of China ; Beijing Natural Science Foundation
WOS IDWOS:000655460900001
PublisherWILEY-V C H VERLAG GMBH
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/48862
Collection中国科学院过程工程研究所
Corresponding AuthorZhang, Xin
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Shen, Jie,Lu, Zhiguo,Wang, Jianze,et al. Traceable Nano-Biohybrid Complexes by One-Step Synthesis as CRISPR-Chem Vectors for Neurodegenerative Diseases Synergistic Treatment[J]. ADVANCED MATERIALS,2021:10.
APA Shen, Jie.,Lu, Zhiguo.,Wang, Jianze.,Hao, Qiulian.,Ji, Weihong.,...&Zhang, Xin.(2021).Traceable Nano-Biohybrid Complexes by One-Step Synthesis as CRISPR-Chem Vectors for Neurodegenerative Diseases Synergistic Treatment.ADVANCED MATERIALS,10.
MLA Shen, Jie,et al."Traceable Nano-Biohybrid Complexes by One-Step Synthesis as CRISPR-Chem Vectors for Neurodegenerative Diseases Synergistic Treatment".ADVANCED MATERIALS (2021):10.
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