Knowledge Management System Of Institute of process engineering,CAS
| The potential of ionic liquids in biopharmaceutical engineering | |
| Lin, Xuan; Su, Zhiguo; Yang, Yanli; Zhang, Songping | |
| 2021-02-01 | |
| Source Publication | CHINESE JOURNAL OF CHEMICAL ENGINEERING
 |
| ISSN | 1004-9541 |
| Volume | 30Pages:236-243 |
| Abstract | Biopharmaceuticals, such as proteins, peptides, nucleic acids and vaccines, bring about great hopes for the prevention and treatment of various diseases, but the industrialization of these products still faces challenges such as structural instability, inefficient bioactivity and low bioavailability. Ionic liquids (ILs), the marvelous solvent media with inimitable and tunable properties, may provide alternative solutions to overcome the above problems of biopharmaceutical industry. Progress has gradually been made through studies by combination of ILs with biomacromolecules. The applications involved the stabilization, protection, and delivery of biopharmaceuticals. Recent trends are being forwarded to using ILs in vaccines and nucleic acid drugs. However, challenges remain on the toxicity and safety issues. Besides, the cost of adding ILs to the benefits of biopharmaceuticals need to be considered. (C) 2020 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved. |
| Keyword | Ionic liquids Biopharmaceutical engineering Biomacromolecules Stabilization Vaccine Delivery |
| DOI | 10.1016/j.cjche.2020.11.015 |
| Language | 英语 |
| WOS Keyword | CONFORMATIONAL STABILITY ; CHEMICAL-STABILITY ; PROTEIN STABILITY ; ACUTE TOXICITY ; DELIVERY ; VACCINE ; DRUG ; INSULIN ; STABILIZATION ; DNA |
| Funding Project | National Natural Science Foundation of China[21808226] ; National Natural Science Foundation of China[31970872] ; National Natural Science Foundation of China[21821005] |
| WOS Research Area | Engineering |
| WOS Subject | Engineering, Chemical |
| Funding Organization | National Natural Science Foundation of China |
| WOS ID | WOS:000651052100024 |
| Publisher | CHEMICAL INDUSTRY PRESS CO LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/48986 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Yang, Yanli; Zhang, Songping |
| Affiliation | Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Lin, Xuan,Su, Zhiguo,Yang, Yanli,et al. The potential of ionic liquids in biopharmaceutical engineering[J]. CHINESE JOURNAL OF CHEMICAL ENGINEERING,2021,30:236-243. |
| APA | Lin, Xuan,Su, Zhiguo,Yang, Yanli,&Zhang, Songping.(2021).The potential of ionic liquids in biopharmaceutical engineering.CHINESE JOURNAL OF CHEMICAL ENGINEERING,30,236-243. |
| MLA | Lin, Xuan,et al."The potential of ionic liquids in biopharmaceutical engineering".CHINESE JOURNAL OF CHEMICAL ENGINEERING 30(2021):236-243. |
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