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The potential of ionic liquids in biopharmaceutical engineering
Lin, Xuan; Su, Zhiguo; Yang, Yanli; Zhang, Songping
2021-02-01
Source PublicationCHINESE JOURNAL OF CHEMICAL ENGINEERING
ISSN1004-9541
Volume30Pages:236-243
AbstractBiopharmaceuticals, such as proteins, peptides, nucleic acids and vaccines, bring about great hopes for the prevention and treatment of various diseases, but the industrialization of these products still faces challenges such as structural instability, inefficient bioactivity and low bioavailability. Ionic liquids (ILs), the marvelous solvent media with inimitable and tunable properties, may provide alternative solutions to overcome the above problems of biopharmaceutical industry. Progress has gradually been made through studies by combination of ILs with biomacromolecules. The applications involved the stabilization, protection, and delivery of biopharmaceuticals. Recent trends are being forwarded to using ILs in vaccines and nucleic acid drugs. However, challenges remain on the toxicity and safety issues. Besides, the cost of adding ILs to the benefits of biopharmaceuticals need to be considered. (C) 2020 The Chemical Industry and Engineering Society of China, and Chemical Industry Press Co., Ltd. All rights reserved.
KeywordIonic liquids Biopharmaceutical engineering Biomacromolecules Stabilization Vaccine Delivery
DOI10.1016/j.cjche.2020.11.015
Language英语
WOS KeywordCONFORMATIONAL STABILITY ; CHEMICAL-STABILITY ; PROTEIN STABILITY ; ACUTE TOXICITY ; DELIVERY ; VACCINE ; DRUG ; INSULIN ; STABILIZATION ; DNA
Funding ProjectNational Natural Science Foundation of China[21808226] ; National Natural Science Foundation of China[31970872] ; National Natural Science Foundation of China[21821005]
WOS Research AreaEngineering
WOS SubjectEngineering, Chemical
Funding OrganizationNational Natural Science Foundation of China
WOS IDWOS:000651052100024
PublisherCHEMICAL INDUSTRY PRESS CO LTD
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/48986
Collection中国科学院过程工程研究所
Corresponding AuthorYang, Yanli; Zhang, Songping
AffiliationChinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Lin, Xuan,Su, Zhiguo,Yang, Yanli,et al. The potential of ionic liquids in biopharmaceutical engineering[J]. CHINESE JOURNAL OF CHEMICAL ENGINEERING,2021,30:236-243.
APA Lin, Xuan,Su, Zhiguo,Yang, Yanli,&Zhang, Songping.(2021).The potential of ionic liquids in biopharmaceutical engineering.CHINESE JOURNAL OF CHEMICAL ENGINEERING,30,236-243.
MLA Lin, Xuan,et al."The potential of ionic liquids in biopharmaceutical engineering".CHINESE JOURNAL OF CHEMICAL ENGINEERING 30(2021):236-243.
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