Cobalt-Catalyzed Chemoselective Transfer Hydrogenative Cyclization Cascade of Enone-Tethered Aldehydes

doi:10.1021/acs.orglett.1c00992

CAS OpenIR

	Cobalt-Catalyzed Chemoselective Transfer Hydrogenative Cyclization Cascade of Enone-Tethered Aldehydes
	Ma, Shuang-Shuang 1,2; Jiang, Biao-Ling 1; Yu, Zheng-Kun 3; Zhang, Suo-Jiang 1,2; Xu, Bao-Hua 1,2,3
	2021-05-21
Source Publication	ORGANIC LETTERS
ISSN	1523-7060
Volume	23 Issue:10 Pages:3873-3878
Abstract	The ligand-free Co-catalyzed chemoselective reductive cyclization cascade of enone-tethered aldehydes with i-PrOH as the environmentally benign hydrogen surrogate is developed by this study. Mechanistic studies disclosed that such a protocol is initiated by an ortho-enone-assisted Co(I)-catalyzed reduction of the aldehyde functionality with i-PrOH. Meanwhile, the selectivity from the Michael-Aldol cycloreduction cascade to the oxa-Michael cascade is feasible and readily adjusted by the addition of steric Lewis bases, such as TEMPO and DABCO, delivering substituted 1H-indenes and dihydroisobenzofurans, respectively.
DOI	10.1021/acs.orglett.1c00992
Language	英语
WOS Keyword	C=O
Funding Project	Excellent Young Scientists Fund[22022815] ; Innovation Academy for Green Manufacture, CAS[IAGM2020C13]
WOS Research Area	Chemistry
WOS Subject	Chemistry, Organic
Funding Organization	Excellent Young Scientists Fund ; Innovation Academy for Green Manufacture, CAS
WOS ID	WOS:000656057300015
Publisher	AMER CHEMICAL SOC
Citation statistics
Document Type	期刊论文
Identifier	http://ir.ipe.ac.cn/handle/122111/49111
Collection	中国科学院过程工程研究所
Corresponding Author	Xu, Bao-Hua
Affiliation	1.Chinese Acad Sci, Inst Proc Engn, Beijing Key Lab Ion Liquids Clean Proc, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Coll Chem & Chem Engn, Beijing 100049, Peoples R China 3.Chinese Acad Sci, Innovat Acad Green Manufacture, Beijing 100190, Peoples R China
First Author Affilication	Center of lonic Liquids and Green Engineering
Corresponding Author Affilication	Center of lonic Liquids and Green Engineering
Recommended Citation GB/T 7714	Ma, Shuang-Shuang,Jiang, Biao-Ling,Yu, Zheng-Kun,et al. Cobalt-Catalyzed Chemoselective Transfer Hydrogenative Cyclization Cascade of Enone-Tethered Aldehydes[J]. ORGANIC LETTERS,2021,23(10):3873-3878.
APA	Ma, Shuang-Shuang,Jiang, Biao-Ling,Yu, Zheng-Kun,Zhang, Suo-Jiang,&Xu, Bao-Hua.(2021).Cobalt-Catalyzed Chemoselective Transfer Hydrogenative Cyclization Cascade of Enone-Tethered Aldehydes.ORGANIC LETTERS,23(10),3873-3878.
MLA	Ma, Shuang-Shuang,et al."Cobalt-Catalyzed Chemoselective Transfer Hydrogenative Cyclization Cascade of Enone-Tethered Aldehydes".ORGANIC LETTERS 23.10(2021):3873-3878.

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