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Cobalt-Catalyzed Chemoselective Transfer Hydrogenative Cyclization Cascade of Enone-Tethered Aldehydes
Ma, Shuang-Shuang1,2; Jiang, Biao-Ling1; Yu, Zheng-Kun3; Zhang, Suo-Jiang1,2; Xu, Bao-Hua1,2,3
2021-05-21
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume23Issue:10Pages:3873-3878
AbstractThe ligand-free Co-catalyzed chemoselective reductive cyclization cascade of enone-tethered aldehydes with i-PrOH as the environmentally benign hydrogen surrogate is developed by this study. Mechanistic studies disclosed that such a protocol is initiated by an ortho-enone-assisted Co(I)-catalyzed reduction of the aldehyde functionality with i-PrOH. Meanwhile, the selectivity from the Michael-Aldol cycloreduction cascade to the oxa-Michael cascade is feasible and readily adjusted by the addition of steric Lewis bases, such as TEMPO and DABCO, delivering substituted 1H-indenes and dihydroisobenzofurans, respectively.
DOI10.1021/acs.orglett.1c00992
Language英语
WOS KeywordC=O
Funding ProjectExcellent Young Scientists Fund[22022815] ; Innovation Academy for Green Manufacture, CAS[IAGM2020C13]
WOS Research AreaChemistry
WOS SubjectChemistry, Organic
Funding OrganizationExcellent Young Scientists Fund ; Innovation Academy for Green Manufacture, CAS
WOS IDWOS:000656057300015
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/49111
Collection中国科学院过程工程研究所
Corresponding AuthorXu, Bao-Hua
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Beijing Key Lab Ion Liquids Clean Proc, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Coll Chem & Chem Engn, Beijing 100049, Peoples R China
3.Chinese Acad Sci, Innovat Acad Green Manufacture, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Ma, Shuang-Shuang,Jiang, Biao-Ling,Yu, Zheng-Kun,et al. Cobalt-Catalyzed Chemoselective Transfer Hydrogenative Cyclization Cascade of Enone-Tethered Aldehydes[J]. ORGANIC LETTERS,2021,23(10):3873-3878.
APA Ma, Shuang-Shuang,Jiang, Biao-Ling,Yu, Zheng-Kun,Zhang, Suo-Jiang,&Xu, Bao-Hua.(2021).Cobalt-Catalyzed Chemoselective Transfer Hydrogenative Cyclization Cascade of Enone-Tethered Aldehydes.ORGANIC LETTERS,23(10),3873-3878.
MLA Ma, Shuang-Shuang,et al."Cobalt-Catalyzed Chemoselective Transfer Hydrogenative Cyclization Cascade of Enone-Tethered Aldehydes".ORGANIC LETTERS 23.10(2021):3873-3878.
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