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Efficient co-production of propionic acid and succinic acid by Propionibacterium acidipropionici using membrane separation coupled technology
Li, Xiaolian; Wei, Liquan; Wang, Ziqiang; Wang, Yunshan; Su, Zhiguo
2021-06-01
Source PublicationENGINEERING IN LIFE SCIENCES
ISSN1618-0240
Volume21Issue:6Pages:429-437
AbstractTo improve the fermentation efficiency of Propionibacterium acidipropionici, a semi-continuous coupled fermentation process was established to achieve co-production of propionic acid (PA) and succinic acid (SA). First, the optimal proportion of glucose (Glc) and glycerol (Gl) as a mixed carbon source was determined, and the feeding procedure of Gl was optimized to make more energy flow in the direction of product synthesis. Then, ZGD630 anion exchange resin was used for efficient adsorption of PA, thereby eliminating the feedback inhibition effect of PA. Finally, an efficient, coupled fermentation process of P. acidipropionici characterized by membrane separation and chromatography technology was developed. The concentrations of PA and SA reached 62.22 +/- 2.32 and 20.45 +/- 1.34 g L-1, with corresponding productivity of 0.43 and 0.14 g L-1 h(-1), increased by 65.38% and 48.54%, respectively. Membrane separation coupled fermentation of PA and SA could significantly improve the process economics of P. acidipropionici, and has good prospects for industrial application.
Keywordcombination of glucose and glycerol membrane separation coupled fermentation Propionibacterium acidipropionici propionic acid succinic acid
DOI10.1002/elsc.202000103
Language英语
WOS KeywordIMMOBILIZED CELLS ; CRUDE GLYCEROL ; FERMENTATION ; SHERMANII ; LACTOSE
WOS Research AreaBiotechnology & Applied Microbiology
WOS SubjectBiotechnology & Applied Microbiology
WOS IDWOS:000658285000009
PublisherWILEY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/49135
Collection中国科学院过程工程研究所
Corresponding AuthorWang, Ziqiang
AffiliationChinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, 1 North 2nd St, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Li, Xiaolian,Wei, Liquan,Wang, Ziqiang,et al. Efficient co-production of propionic acid and succinic acid by Propionibacterium acidipropionici using membrane separation coupled technology[J]. ENGINEERING IN LIFE SCIENCES,2021,21(6):429-437.
APA Li, Xiaolian,Wei, Liquan,Wang, Ziqiang,Wang, Yunshan,&Su, Zhiguo.(2021).Efficient co-production of propionic acid and succinic acid by Propionibacterium acidipropionici using membrane separation coupled technology.ENGINEERING IN LIFE SCIENCES,21(6),429-437.
MLA Li, Xiaolian,et al."Efficient co-production of propionic acid and succinic acid by Propionibacterium acidipropionici using membrane separation coupled technology".ENGINEERING IN LIFE SCIENCES 21.6(2021):429-437.
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