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Docking study of HDAC implication for benzamide inhibitors binding mode
Alternative TitleActa Phys.-Chim. Sin.
Xie, AH; Li, BY; Liao, CZ; Li, ZB; Lu, XP; Shi, LM; Zhou, JJ
2004-06-01
Source PublicationACTA PHYSICO-CHIMICA SINICA
ISSN1000-6818
Volume20Issue:6Pages:569-572
AbstractThe paper proposed a possible binding mode of MS-275, a benzamide historic deacetylase(HDAC) inhibitor, to HDAC by intensive docking study. This binding mode is different from those observed in the crystal structure of complexes formed by a histone deacetylase-like protein (HDLP) with trichostatin A(TSA) or suberoylanilide hydroxamic acid (SARA). The docking result implicates that the main target of MS-275 is the narrowest part of HDAC active pocket. It seems to be able to explain the low toxicity of MS-275 and provides new insights on the design of novel HDAC inhibitors.; The paper proposed a possible binding mode of MS-275, a benzamide historic deacetylase(HDAC) inhibitor, to HDAC by intensive docking study. This binding mode is different from those observed in the crystal structure of complexes formed by a histone deacetylase-like protein (HDLP) with trichostatin A(TSA) or suberoylanilide hydroxamic acid (SARA). The docking result implicates that the main target of MS-275 is the narrowest part of HDAC active pocket. It seems to be able to explain the low toxicity of MS-275 and provides new insights on the design of novel HDAC inhibitors.
KeywordHistone Deacetylase(Hdac) Histone Deacetylase Like Protein(Hdlp) Trichostatin a (Tsa) Docking Ms-275
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.3866/PKU.WHXB20040603
URL查看原文
Indexed BySCI
Language英语
WOS KeywordHISTONE DEACETYLASE ; ACID ; TRANSCRIPTION ; ACETYLATION ; LEUKEMIA
WOS Research AreaChemistry
WOS SubjectChemistry, Physical
WOS IDWOS:000222223400003
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/4917
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Beijing 100080, Peoples R China
2.Chipscreen Biosci Ltd, Shenzhen 518057, Peoples R China
Recommended Citation
GB/T 7714
Xie, AH,Li, BY,Liao, CZ,et al. Docking study of HDAC implication for benzamide inhibitors binding mode[J]. ACTA PHYSICO-CHIMICA SINICA,2004,20(6):569-572.
APA Xie, AH.,Li, BY.,Liao, CZ.,Li, ZB.,Lu, XP.,...&Zhou, JJ.(2004).Docking study of HDAC implication for benzamide inhibitors binding mode.ACTA PHYSICO-CHIMICA SINICA,20(6),569-572.
MLA Xie, AH,et al."Docking study of HDAC implication for benzamide inhibitors binding mode".ACTA PHYSICO-CHIMICA SINICA 20.6(2004):569-572.
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