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Hollow structures as drug carriers: Recognition, response, and release
Zhao, Decai1,2; Yang, Nailiang1,2; Xu, Lekai1,3,4; Du, Jiang3,4; Yang, Yang5,6; Wang, Dan1,2
2021-07-08
Source PublicationNANO RESEARCH
ISSN1998-0124
Pages19
AbstractHollow structures have demonstrated great potential in drug delivery owing to their privileged structure, such as high surface-to-volume ratio, low density, large cavities, and hierarchical pores. In this review, we provide a comprehensive overview of hollow structured materials applied in targeting recognition, smart response, and drug release, and we have addressed the possible chemical factors and reactions in these three processes. The advantages of hollow nanostructures are summarized as follows: hollow cavity contributes to large loading capacity; a tailored structure helps controllable drug release; variable compounds adapt to flexible application; surface modification facilitates smart responsive release. Especially, because the multiple physical barriers and chemical interactions can be induced by multishells, hollow multishelled structure is considered as a promising material with unique loading and releasing properties. Finally, we conclude this review with some perspectives on the future research and development of the hollow structures as drug carriers.
Keywordhollow structure drug delivery system carriers spatiotemporal
DOI10.1007/s12274-021-3595-5
Language英语
WOS KeywordMESOPOROUS SILICA NANOPARTICLES ; METAL-ORGANIC FRAMEWORK ; IN-VITRO ; DELIVERY-SYSTEM ; TEMPLATING SYNTHESIS ; SUSTAINED-RELEASE ; ORGANOSILICA NANOCAPSULES ; SHELL NANOPARTICLES ; SEQUENTIAL RELEASE ; LOADING CAPACITY
Funding ProjectNational Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[21820102002] ; National Natural Science Foundation of China[21971244] ; National Key R&D Program of China[2016YFB0600903]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
Funding OrganizationNational Natural Science Foundation of China ; National Key R&D Program of China
WOS IDWOS:000671718700005
PublisherTSINGHUA UNIV PRESS
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/49407
Collection中国科学院过程工程研究所
Corresponding AuthorYang, Nailiang; Yang, Yang; Wang, Dan
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Zhengzhou Univ, Sch Mat Sci & Engn, Green Catalysis Ctr, Zhengzhou 450001, Peoples R China
4.Zhengzhou Univ, Sch Mat Sci & Engn, Coll Chem, Zhengzhou 450001, Peoples R China
5.Tongji Univ, Shanghai Pulm Hosp, Sch Med, Dept Thorac Surg, Shanghai 200433, Peoples R China
6.Tongji Univ, Sch Mat Sci & Engn, Shanghai 201804, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Decai,Yang, Nailiang,Xu, Lekai,et al. Hollow structures as drug carriers: Recognition, response, and release[J]. NANO RESEARCH,2021:19.
APA Zhao, Decai,Yang, Nailiang,Xu, Lekai,Du, Jiang,Yang, Yang,&Wang, Dan.(2021).Hollow structures as drug carriers: Recognition, response, and release.NANO RESEARCH,19.
MLA Zhao, Decai,et al."Hollow structures as drug carriers: Recognition, response, and release".NANO RESEARCH (2021):19.
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