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Simulation of nanoparticles interacting with a cell membrane: probing the structural basis and potential biomedical application
Zhang, Xiao1; Ma, Guanghui1,2; Wei, Wei1,2
2021-07-16
Source PublicationNPG ASIA MATERIALS
ISSN1884-4049
Volume13Issue:1Pages:18
AbstractNanoparticles (NPs), owing to their ultrasmall size, have been extensively researched for potential applications in biomedicine. During their delivery and functionalization within the organism, they frequently interact with cells. The resulting nano-bio interfaces between the NPs and cell membrane play an important role in dominating the physiological effects of NPs. Therefore, understanding how the properties of NPs affect their nano-bio interface interactions with the cell membrane is important. Compared to experimental and theoretical analyses, simulations can provide atomic-level accuracy regarding dynamic changes in structure, which can reveal the mechanisms of nano-bio interface interactions for feasible modulation. Thus, we reviewed the current advances in nano-bio interfaces from the perspective of simulations. This study will determine how the properties of NPs affect their interactions with cell membranes to provide insights for the design of NPs and summarize their corresponding biomedical applications.
DOI10.1038/s41427-021-00320-0
Language英语
WOS KeywordRECEPTOR-MEDIATED ENDOCYTOSIS ; FORCE-FIELD ; COMPUTER-SIMULATION ; SHAPE ANISOTROPY ; BIO INTERFACE ; TRANSLOCATION ; NANOMATERIALS ; PERMEATION ; ADSORPTION ; EXTRACTION
Funding ProjectNational Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[32030062] ; National Natural Science Foundation of China[U2001224] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
WOS IDWOS:000674639200003
PublisherNATURE RESEARCH
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/49441
Collection中国科学院过程工程研究所
Corresponding AuthorWei, Wei
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, 1 Bei Er Tiao, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, 19A Yuquan Rd, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Xiao,Ma, Guanghui,Wei, Wei. Simulation of nanoparticles interacting with a cell membrane: probing the structural basis and potential biomedical application[J]. NPG ASIA MATERIALS,2021,13(1):18.
APA Zhang, Xiao,Ma, Guanghui,&Wei, Wei.(2021).Simulation of nanoparticles interacting with a cell membrane: probing the structural basis and potential biomedical application.NPG ASIA MATERIALS,13(1),18.
MLA Zhang, Xiao,et al."Simulation of nanoparticles interacting with a cell membrane: probing the structural basis and potential biomedical application".NPG ASIA MATERIALS 13.1(2021):18.
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