CAS OpenIR
Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells
Tian, Ying1,2; Zhang, Fan2,3; Qiu, Yefeng4; Wang, Shuang2; Li, Feng2,5; Zhao, Jiawei2; Pan, Chao6; Tao, Yong1; Yu, Di7; Wei, Wei2,5
2021-07-26
Source PublicationNATURE BIOMEDICAL ENGINEERING
ISSN2157-846X
Pages19
AbstractIntravitreally injected exosomes derived from regulatory T cells and conjugated with an antibody for vascular endothelial growth factor via a cleavable linker markedly suppress ocular neovascularization in mice and non-human primates. Choroidal neovascularization induced by age-related macular degeneration and retinal neovascularization induced by diabetic retinopathy-two leading causes of blindness-are often treated using antibodies targeting vascular endothelial growth factor (VEGF). Here we report a strong association between inflammation and high VEGF expression in aqueous humour samples from patients with choroidal or retinal neovascularization, and show that intravitreally injected exosomes derived from regulatory T cells and conjugated with an anti-VEGF antibody via a peptide linker that is cleavable by matrix metalloproteinases markedly suppressed ocular neovascularization in mouse and non-human primate models of choroidal neovascularization. The engineered exosomes, which selectively accumulate in the neovascularization lesions, could be adapted for other combination therapies of therapeutic antibodies and anti-inflammatory cargo.
DOI10.1038/s41551-021-00764-3
Language英语
WOS KeywordMACULAR DEGENERATION ; INFLAMMATORY CYTOKINES ; INTRAVITREAL DEXAMETHASONE ; AQUEOUS-HUMOR ; BEVACIZUMAB ; RANIBIZUMAB ; MODELS ; NAIVE
Funding ProjectNational Natural Science Foundation of China[82070948] ; National Natural Science Foundation of China[U2001224] ; Beijing Chaoyang 1351 talent training programme[CYXX-2017-21] ; Scientific Research Program of Beijing Municipal Commission of Education[KM202010025020]
WOS Research AreaEngineering
WOS SubjectEngineering, Biomedical
Funding OrganizationNational Natural Science Foundation of China ; Beijing Chaoyang 1351 talent training programme ; Scientific Research Program of Beijing Municipal Commission of Education
WOS IDWOS:000677707300002
PublisherNATURE RESEARCH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/49523
Collection中国科学院过程工程研究所
Corresponding AuthorTao, Yong; Yu, Di; Wei, Wei
Affiliation1.Capital Med Univ, Beijing Chaoyang Hosp, Dept Ophthalmol, Beijing, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China
3.Sun Yat Sen Univ, Sch Pharmaceut Sci Shenzhen, Shenzhen, Peoples R China
4.Acad Mil Med Sci, Anim Ctr, Beijing, Peoples R China
5.Univ Chinese Acad Sci, Sch Chem Engn, Beijing, Peoples R China
6.Beijing Inst Biotechnol, State Key Lab Pathogen & Biosecur, Beijing, Peoples R China
7.Univ Queensland, Fac Med, Diamantina Inst, Brisbane, Qld, Australia
Recommended Citation
GB/T 7714
Tian, Ying,Zhang, Fan,Qiu, Yefeng,et al. Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells[J]. NATURE BIOMEDICAL ENGINEERING,2021:19.
APA Tian, Ying.,Zhang, Fan.,Qiu, Yefeng.,Wang, Shuang.,Li, Feng.,...&Wei, Wei.(2021).Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells.NATURE BIOMEDICAL ENGINEERING,19.
MLA Tian, Ying,et al."Reduction of choroidal neovascularization via cleavable VEGF antibodies conjugated to exosomes derived from regulatory T cells".NATURE BIOMEDICAL ENGINEERING (2021):19.
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