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A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin
Alternative TitleBiotechnol. Lett.
Yun, Q; He, ML; Xing, WC; Bi, JX; Ma, GH; Su, ZG
2004-09-01
Source PublicationBIOTECHNOLOGY LETTERS
ISSN0141-5492
Volume26Issue:17Pages:1359-1363
AbstractA novel tetrafunctional reagent, alpha, gamma, alpha', gamma'-tetra-succinimidyl-hexanediamide-di-glutamate ester (HDG(OSU)(4)), was successfully synthesized, and a well-defined cross-linked bovine hemoglobin (mainly 128 kDa) was prepared with this reagent. Due to the spatial structure of this cross-linking reagent, the intramolecular and intermolecular cross-linking of bovine hemoglobin was formed simultaneously in one reaction. Although the cross-linked bovine hemoc,lobin showed a slight decrease in half-saturated O-2 pressure value (P-50, from 28.1 mm Hg to 21.7 mm Hg) and Ell coefficient (from 2.5 to 2), due to the cross-linkage, it still performed well for O-2 delivery.; A novel tetrafunctional reagent, alpha, gamma, alpha', gamma'-tetra-succinimidyl-hexanediamide-di-glutamate ester (HDG(OSU)(4)), was successfully synthesized, and a well-defined cross-linked bovine hemoglobin (mainly 128 kDa) was prepared with this reagent. Due to the spatial structure of this cross-linking reagent, the intramolecular and intermolecular cross-linking of bovine hemoglobin was formed simultaneously in one reaction. Although the cross-linked bovine hemoc,lobin showed a slight decrease in half-saturated O-2 pressure value (P-50, from 28.1 mm Hg to 21.7 mm Hg) and Ell coefficient (from 2.5 to 2), due to the cross-linkage, it still performed well for O-2 delivery.
KeywordBlood Substitute Bovine Hemoglobin Cross-linking Reagent Modification
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
URL查看原文
Indexed BySCI
Language英语
WOS KeywordBLOOD SUBSTITUTE
WOS Research AreaBiotechnology & Applied Microbiology
WOS SubjectBiotechnology & Applied Microbiology
WOS IDWOS:000225103700008
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/4975
Collection研究所(批量导入)
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Natl Lab Biochem Engn, Beijing 100080, Peoples R China
2.Chinese Acad Sci, Xinjiang Tech Inst Phys & Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Yun, Q,He, ML,Xing, WC,et al. A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin[J]. BIOTECHNOLOGY LETTERS,2004,26(17):1359-1363.
APA Yun, Q,He, ML,Xing, WC,Bi, JX,Ma, GH,&Su, ZG.(2004).A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin.BIOTECHNOLOGY LETTERS,26(17),1359-1363.
MLA Yun, Q,et al."A novel tetrafunctional reagent for simultaneous intramolecular and intermolecular cross-linking of bovine hemoglobin".BIOTECHNOLOGY LETTERS 26.17(2004):1359-1363.
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