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Preparation of microspheres with microballoons inside for floating drug-delivery systems
Alternative TitleJ. Appl. Polym. Sci.
Yang, ZQ; Song, BZ; Li, QX; Fan, HL; Fan, OY
2004-10-05
Source PublicationJOURNAL OF APPLIED POLYMER SCIENCE
ISSN0021-8995
Volume94Issue:1Pages:197-202
AbstractThe use of floating drug-delivery systems is one method that is used to achieve prolonged gastric residence times. We developed a novel, multiple-unit, floating drug-delivery system of microspheres with microballoons inside from xanthan gum (XG) and gelatin (GA) by a water-in-oil method. With theophylline as the model drug, four formulations (FI-FIV) with different ratios of the two polymers were prepared. The size distribution, drug-encapsulation efficiency, floating behavior, release characteristics, and morphological properties were investigated. The ratio of the two polymers influenced the size distribution, encapsulation efficiency, and drug release appreciably. With increasing amounts of GA, the percentage yield of the floating microspheres and the drug-encapsulation efficiency decreased from 100 and 84.5% to 31 and 56.2%, respectively. The drug-release rate also decreased with increasing GA content, which was attributed to an increase in the crosslinking extent. An initial burst was observed, and after that, the drug was released slowly by a near-zero-order pattern, which was attributed to the low solubility of theophylline and the possible complexes formed by XG and GA in the simulated gastric fluid (pH 1.2). (C) 2004 Wiley Periodicals, Inc.; The use of floating drug-delivery systems is one method that is used to achieve prolonged gastric residence times. We developed a novel, multiple-unit, floating drug-delivery system of microspheres with microballoons inside from xanthan gum (XG) and gelatin (GA) by a water-in-oil method. With theophylline as the model drug, four formulations (FI-FIV) with different ratios of the two polymers were prepared. The size distribution, drug-encapsulation efficiency, floating behavior, release characteristics, and morphological properties were investigated. The ratio of the two polymers influenced the size distribution, encapsulation efficiency, and drug release appreciably. With increasing amounts of GA, the percentage yield of the floating microspheres and the drug-encapsulation efficiency decreased from 100 and 84.5% to 31 and 56.2%, respectively. The drug-release rate also decreased with increasing GA content, which was attributed to an increase in the crosslinking extent. An initial burst was observed, and after that, the drug was released slowly by a near-zero-order pattern, which was attributed to the low solubility of theophylline and the possible complexes formed by XG and GA in the simulated gastric fluid (pH 1.2). (C) 2004 Wiley Periodicals, Inc.
KeywordPolysaccharides Drug Delivery Systems Microencapsulation Particle Size Distribution
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences
DOI10.1002/app.20856
URL查看原文
Indexed BySCI
Language英语
WOS KeywordGASTROINTESTINAL-TRACT ; RELEASE ; MICROCAPSULES ; THEOPHYLLINE ; PELLETS
WOS Research AreaPolymer Science
WOS SubjectPolymer Science
WOS IDWOS:000223459500024
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/4997
Collection研究所(批量导入)
AffiliationChinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Yang, ZQ,Song, BZ,Li, QX,et al. Preparation of microspheres with microballoons inside for floating drug-delivery systems[J]. JOURNAL OF APPLIED POLYMER SCIENCE,2004,94(1):197-202.
APA Yang, ZQ,Song, BZ,Li, QX,Fan, HL,&Fan, OY.(2004).Preparation of microspheres with microballoons inside for floating drug-delivery systems.JOURNAL OF APPLIED POLYMER SCIENCE,94(1),197-202.
MLA Yang, ZQ,et al."Preparation of microspheres with microballoons inside for floating drug-delivery systems".JOURNAL OF APPLIED POLYMER SCIENCE 94.1(2004):197-202.
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