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Thermal-triggered packing of lipophilic NIR dye IR780 in hepatitis B core at critical ionic strength and cargo-host ratio for improved stability and enhanced cancer phototherapy
Lu, Fengying1,2; Li, Zhengjun1; Sheng, Yanan1; Ma, Yanyan1; Yang, Yanli1; Ren, Ying3; Su, Zhiguo1; Yu, Rong2; Zhang, Songping1
2021-09-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume276Pages:14
AbstractVirus-like particles (VLPs) holding internal cavity with diameter from tens up to one hundred nanometers are attractive platform for drug delivery. Nevertheless, the packing of drugs in the nanocage mainly relies on complicated disassembly-reassembly process. In this study, hepatitis B core protein (HBc) VLPs which can withstand temperature up to 90 degrees C was employed as carrier to load a lipophilic near infrared dye IR780. It was found that an attaching-dis-atching-diffusing process was involved for the entering of IR780 in the cavity of HBc. The first two steps were associated with the electrostatic interactions between oppositely charged HBc and IR780, which was critically manipulated by ionic strength and HBc/IR780 mass ratio at which they were mixed; while the diffusion of IR780 across the shell of HBc showed a temperature-dependent manner that can be triggered by thermal induced pore-opening of the HBc capsid. At optimized condition, about 1055 IR780 molecules were encapsulated in each HBc by simply mixing them for 10 min at 60 degrees C. Compared with free IR780, the HBc-IR780 particles showed significantly improved aqueous and photostability, as well as enhanced photothermal and photodynamic performance for cancer therapy. This study provides a novel drug loading strategy and nanomemedicine for cancer phototherapies.
KeywordHBc VLP Nanocage IR780 Encapsulation Phototherapy
DOI10.1016/j.biomaterials.2021.121035
Language英语
WOS KeywordVIRUS-LIKE PARTICLES ; TRANSFER RADICAL POLYMERIZATION ; IR-780 DYE ; NANOPARTICLES ; ENCAPSULATION ; NANOCARRIERS ; DELIVERY ; ANTIGEN
Funding ProjectNational Natural Science Foundation of China[31970872] ; National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[21973097]
WOS Research AreaEngineering ; Materials Science
WOS SubjectEngineering, Biomedical ; Materials Science, Biomaterials
Funding OrganizationNational Natural Science Foundation of China
WOS IDWOS:000690381900002
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/50035
Collection中国科学院过程工程研究所
Corresponding AuthorYu, Rong; Zhang, Songping
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Minist Educ, Chengdu 610041, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Multiphase Complex Syst, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Lu, Fengying,Li, Zhengjun,Sheng, Yanan,et al. Thermal-triggered packing of lipophilic NIR dye IR780 in hepatitis B core at critical ionic strength and cargo-host ratio for improved stability and enhanced cancer phototherapy[J]. BIOMATERIALS,2021,276:14.
APA Lu, Fengying.,Li, Zhengjun.,Sheng, Yanan.,Ma, Yanyan.,Yang, Yanli.,...&Zhang, Songping.(2021).Thermal-triggered packing of lipophilic NIR dye IR780 in hepatitis B core at critical ionic strength and cargo-host ratio for improved stability and enhanced cancer phototherapy.BIOMATERIALS,276,14.
MLA Lu, Fengying,et al."Thermal-triggered packing of lipophilic NIR dye IR780 in hepatitis B core at critical ionic strength and cargo-host ratio for improved stability and enhanced cancer phototherapy".BIOMATERIALS 276(2021):14.
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