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| Thermal-triggered packing of lipophilic NIR dye IR780 in hepatitis B core at critical ionic strength and cargo-host ratio for improved stability and enhanced cancer phototherapy | |
| Lu, Fengying1,2; Li, Zhengjun1; Sheng, Yanan1; Ma, Yanyan1; Yang, Yanli1; Ren, Ying3; Su, Zhiguo1; Yu, Rong2; Zhang, Songping1 | |
| 2021-09-01 | |
| Source Publication | BIOMATERIALS
 |
| ISSN | 0142-9612 |
| Volume | 276Pages:14 |
| Abstract | Virus-like particles (VLPs) holding internal cavity with diameter from tens up to one hundred nanometers are attractive platform for drug delivery. Nevertheless, the packing of drugs in the nanocage mainly relies on complicated disassembly-reassembly process. In this study, hepatitis B core protein (HBc) VLPs which can withstand temperature up to 90 degrees C was employed as carrier to load a lipophilic near infrared dye IR780. It was found that an attaching-dis-atching-diffusing process was involved for the entering of IR780 in the cavity of HBc. The first two steps were associated with the electrostatic interactions between oppositely charged HBc and IR780, which was critically manipulated by ionic strength and HBc/IR780 mass ratio at which they were mixed; while the diffusion of IR780 across the shell of HBc showed a temperature-dependent manner that can be triggered by thermal induced pore-opening of the HBc capsid. At optimized condition, about 1055 IR780 molecules were encapsulated in each HBc by simply mixing them for 10 min at 60 degrees C. Compared with free IR780, the HBc-IR780 particles showed significantly improved aqueous and photostability, as well as enhanced photothermal and photodynamic performance for cancer therapy. This study provides a novel drug loading strategy and nanomemedicine for cancer phototherapies. |
| Keyword | HBc VLP Nanocage IR780 Encapsulation Phototherapy |
| DOI | 10.1016/j.biomaterials.2021.121035 |
| Language | 英语 |
| WOS Keyword | VIRUS-LIKE PARTICLES ; TRANSFER RADICAL POLYMERIZATION ; IR-780 DYE ; NANOPARTICLES ; ENCAPSULATION ; NANOCARRIERS ; DELIVERY ; ANTIGEN |
| Funding Project | National Natural Science Foundation of China[31970872] ; National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[21973097] |
| WOS Research Area | Engineering ; Materials Science |
| WOS Subject | Engineering, Biomedical ; Materials Science, Biomaterials |
| Funding Organization | National Natural Science Foundation of China |
| WOS ID | WOS:000690381900002 |
| Publisher | ELSEVIER SCI LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/50035 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Yu, Rong; Zhang, Songping |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Sichuan Univ, West China Sch Pharm, Key Lab Drug Targeting & Drug Delivery Syst, Minist Educ, Chengdu 610041, Peoples R China 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Multiphase Complex Syst, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Lu, Fengying,Li, Zhengjun,Sheng, Yanan,et al. Thermal-triggered packing of lipophilic NIR dye IR780 in hepatitis B core at critical ionic strength and cargo-host ratio for improved stability and enhanced cancer phototherapy[J]. BIOMATERIALS,2021,276:14. |
| APA | Lu, Fengying.,Li, Zhengjun.,Sheng, Yanan.,Ma, Yanyan.,Yang, Yanli.,...&Zhang, Songping.(2021).Thermal-triggered packing of lipophilic NIR dye IR780 in hepatitis B core at critical ionic strength and cargo-host ratio for improved stability and enhanced cancer phototherapy.BIOMATERIALS,276,14. |
| MLA | Lu, Fengying,et al."Thermal-triggered packing of lipophilic NIR dye IR780 in hepatitis B core at critical ionic strength and cargo-host ratio for improved stability and enhanced cancer phototherapy".BIOMATERIALS 276(2021):14. |
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