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A biological functional hybrid scaffold based on decellularized extracellular matrix/gelatin/chitosan with high biocompatibility and antibacterial activity for skin tissue engineering
Xu, Jie1; Fang, Huan1; Zheng, Shuangshuang2; Li, Liying1; Jiao, Zeren3; Wang, Hong4; Nie, Yi2,5; Liu, Tianqing1; Song, Kedong1
2021-09-30
Source PublicationINTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
ISSN0141-8130
Volume187Pages:840-849
AbstractNowadays, decellularized extracellular matrix (dECM) has received widespread attention due to its diversity in providing the unique structural and functional components to support cell growth, and finding material with good biocompatibility and anti-infection capability for skin tissue engineering is still a challenge. In this study, a novel dECM/Gel/CS scaffold with appropriate mechanical strength, good antibacterial activity and high biocompatibility was prepared using a one-pot method. The results showed that the immune components such as cells and DNA (about 98.1%) were successfully removed from the porcine skin tissue. The dECM/Gel/CS scaf-folds exhibited an interconnected pore structure and had a high porosity (>90%) to promote cell growth. Moreover, the appropriate elastic modulus (>482.17 kPa) and degradability (>80.04% for 15 days) of the scaffolds offered stout "houses" for cell proliferation and suitable degradation rate to match the new tissue formation in skin tissue engineering. Furthermore, the addition of chitosan endowed the scaffold with good antibacterial activity, water and protein absorption capacity to avoid wound infection, and maintain the mois-ture and nutrition balance. In vitro cytocompatibility studies showed that the presence of dECM effectively enhanced the cell proliferation. Overall, the advanced dECM/Gel/CS scaffold has considerable potential to be applied in skin tissue engineering.
KeywordAntibacterial Skin tissue engineering Decellularized extracellular matrix
DOI10.1016/j.ijbiomac.2021.07.162
Language英语
WOS KeywordMATRIX BIOINK ; MECHANICAL-PROPERTIES ; NANOFIBROUS MATS ; HYDROGEL ; CONSTRUCTS ; THERAPY
Funding ProjectNational Natural Science Foundation of China[31670978/21676041] ; Fok Ying Tung Education Foun-dation[132027] ; State Key Laboratory of Fire Science[KF1111] ; Natural Science Foundation of Liaoning[20180510028] ; Fundamental Research Funds for the Central Universities[DUT20ZD206/DUT20YG118/DUT21YG113]
WOS Research AreaBiochemistry & Molecular Biology ; Chemistry ; Polymer Science
WOS SubjectBiochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science
Funding OrganizationNational Natural Science Foundation of China ; Fok Ying Tung Education Foun-dation ; State Key Laboratory of Fire Science ; Natural Science Foundation of Liaoning ; Fundamental Research Funds for the Central Universities
WOS IDWOS:000691784600003
PublisherELSEVIER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/50098
Collection中国科学院过程工程研究所
Corresponding AuthorWang, Hong; Nie, Yi; Liu, Tianqing; Song, Kedong
Affiliation1.Dalian Univ Technol, Dalian R&D Ctr Stem Cell & Tissue Engn, State Key Lab Fine Chem, Dalian 116024, Peoples R China
2.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Peoples R China
3.Texas A&M Univ, Artie McFerrin Dept Chem Engn, College Stn, TX 77843 USA
4.Dalian Med Univ, Dept Orthopead, Dalian Municipal Cent Hosp, Dalian 116033, Peoples R China
5.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xu, Jie,Fang, Huan,Zheng, Shuangshuang,et al. A biological functional hybrid scaffold based on decellularized extracellular matrix/gelatin/chitosan with high biocompatibility and antibacterial activity for skin tissue engineering[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,187:840-849.
APA Xu, Jie.,Fang, Huan.,Zheng, Shuangshuang.,Li, Liying.,Jiao, Zeren.,...&Song, Kedong.(2021).A biological functional hybrid scaffold based on decellularized extracellular matrix/gelatin/chitosan with high biocompatibility and antibacterial activity for skin tissue engineering.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,187,840-849.
MLA Xu, Jie,et al."A biological functional hybrid scaffold based on decellularized extracellular matrix/gelatin/chitosan with high biocompatibility and antibacterial activity for skin tissue engineering".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 187(2021):840-849.
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