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| A biological functional hybrid scaffold based on decellularized extracellular matrix/gelatin/chitosan with high biocompatibility and antibacterial activity for skin tissue engineering | |
| Xu, Jie1; Fang, Huan1; Zheng, Shuangshuang2; Li, Liying1; Jiao, Zeren3; Wang, Hong4; Nie, Yi2,5; Liu, Tianqing1; Song, Kedong1 | |
| 2021-09-30 | |
| Source Publication | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| ISSN | 0141-8130 |
| Volume | 187Pages:840-849 |
| Abstract | Nowadays, decellularized extracellular matrix (dECM) has received widespread attention due to its diversity in providing the unique structural and functional components to support cell growth, and finding material with good biocompatibility and anti-infection capability for skin tissue engineering is still a challenge. In this study, a novel dECM/Gel/CS scaffold with appropriate mechanical strength, good antibacterial activity and high biocompatibility was prepared using a one-pot method. The results showed that the immune components such as cells and DNA (about 98.1%) were successfully removed from the porcine skin tissue. The dECM/Gel/CS scaf-folds exhibited an interconnected pore structure and had a high porosity (>90%) to promote cell growth. Moreover, the appropriate elastic modulus (>482.17 kPa) and degradability (>80.04% for 15 days) of the scaffolds offered stout "houses" for cell proliferation and suitable degradation rate to match the new tissue formation in skin tissue engineering. Furthermore, the addition of chitosan endowed the scaffold with good antibacterial activity, water and protein absorption capacity to avoid wound infection, and maintain the mois-ture and nutrition balance. In vitro cytocompatibility studies showed that the presence of dECM effectively enhanced the cell proliferation. Overall, the advanced dECM/Gel/CS scaffold has considerable potential to be applied in skin tissue engineering. |
| Keyword | Antibacterial Skin tissue engineering Decellularized extracellular matrix |
| DOI | 10.1016/j.ijbiomac.2021.07.162 |
| Language | 英语 |
| WOS Keyword | MATRIX BIOINK ; MECHANICAL-PROPERTIES ; NANOFIBROUS MATS ; HYDROGEL ; CONSTRUCTS ; THERAPY |
| Funding Project | National Natural Science Foundation of China[31670978/21676041] ; Fok Ying Tung Education Foun-dation[132027] ; State Key Laboratory of Fire Science[KF1111] ; Natural Science Foundation of Liaoning[20180510028] ; Fundamental Research Funds for the Central Universities[DUT20ZD206/DUT20YG118/DUT21YG113] |
| WOS Research Area | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| WOS Subject | Biochemistry & Molecular Biology ; Chemistry, Applied ; Polymer Science |
| Funding Organization | National Natural Science Foundation of China ; Fok Ying Tung Education Foun-dation ; State Key Laboratory of Fire Science ; Natural Science Foundation of Liaoning ; Fundamental Research Funds for the Central Universities |
| WOS ID | WOS:000691784600003 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/50098 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Wang, Hong; Nie, Yi; Liu, Tianqing; Song, Kedong |
| Affiliation | 1.Dalian Univ Technol, Dalian R&D Ctr Stem Cell & Tissue Engn, State Key Lab Fine Chem, Dalian 116024, Peoples R China 2.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Peoples R China 3.Texas A&M Univ, Artie McFerrin Dept Chem Engn, College Stn, TX 77843 USA 4.Dalian Med Univ, Dept Orthopead, Dalian Municipal Cent Hosp, Dalian 116033, Peoples R China 5.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Xu, Jie,Fang, Huan,Zheng, Shuangshuang,et al. A biological functional hybrid scaffold based on decellularized extracellular matrix/gelatin/chitosan with high biocompatibility and antibacterial activity for skin tissue engineering[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,187:840-849. |
| APA | Xu, Jie.,Fang, Huan.,Zheng, Shuangshuang.,Li, Liying.,Jiao, Zeren.,...&Song, Kedong.(2021).A biological functional hybrid scaffold based on decellularized extracellular matrix/gelatin/chitosan with high biocompatibility and antibacterial activity for skin tissue engineering.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,187,840-849. |
| MLA | Xu, Jie,et al."A biological functional hybrid scaffold based on decellularized extracellular matrix/gelatin/chitosan with high biocompatibility and antibacterial activity for skin tissue engineering".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 187(2021):840-849. |
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