CAS OpenIR
In situ growth of nano-antioxidants on cellular vesicles for efficient reactive oxygen species elimination in acute inflammatory diseases
Zhao, Jiawei1,2; Wang, Yugang2; Wang, Wenjing1,4; Tian, Ying1,5; Gan, Zhongdong1; Wang, Yanlei3,6; He, Hongyan3,6; Chen, Wei7; Zhang, Xiao1; Wu, Yuanbin8; Jia, Rongrong2; Shi, Min2; Wei, Wei1,3; Ma, Guanghui1,3
2021-10-01
Source PublicationNANO TODAY
ISSN1748-0132
Volume40Pages:17
AbstractReactive oxygen species (ROS) are key contributors to inflammatory progression and damage. Upon clinical and experimental observation of vascular abnormalities in acute inflammatory diseases, we explore cellular vesicles as templates and carriers to elevate therapeutic performance of nano-antioxidant. Specifically, we develop a mild one-pot approach for in situ growth of cerium oxide (Ce) nanocrystals onto nano-sized red blood cells vesicles (ReVs). Besides excellent biocompatibility, Ce-ReVs have very high ROS-scavenging activity, which is experimentally and theoretically explained by discovering the unique functions of membrane lipids in optimizing Ce nanocrystals with ultrasmall size (similar to 3 nm) and ultrahigh Ce(III) content (similar to 60.8%). In colitis and acute liver injury models, Ce-ReVs notably enhance accumulation at the inflamed sites and confer strong ROS elimination. Moreover, we upgrade the system by hybridizing ReVs with mesenchymal stem cell-derived exosomes and demonstrate additional repair function of highly damaged tissues, further verifying the satisfactory flexibility and therapeutic efficacy. (C) 2021 The Author(s). Published by Elsevier Ltd.
KeywordColitis Cerium oxide Inflammatory diseases Reactive oxygen species
DOI10.1016/j.nantod.2021.101282
Language英语
WOS KeywordOXIDATIVE STRESS ; NANOPARTICLES ; METABOLISM ; DYNAMICS ; CERIA ; DRUG
Funding ProjectNational Natural Science Foundation of China[81871912] ; National Natural Science Foundation of China[81970530] ; National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[32030062] ; National Natural Science Foundation of China[U2001224] ; Shanghai Municipal Health Bureau Key Disciplines Grant[ZK2019C012] ; National Science and Technology Major Project of China[2018ZX10301-103-003]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; Shanghai Municipal Health Bureau Key Disciplines Grant ; National Science and Technology Major Project of China
WOS IDWOS:000703972200003
PublisherELSEVIER SCI LTD
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/50412
Collection中国科学院过程工程研究所
Corresponding AuthorShi, Min; Wei, Wei; Ma, Guanghui
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Shanghai Jiao Tong Univ, Tongren Hosp, Dept Gastroenterol, Sch Med, Shanghai 200336, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
4.Shenzhen Univ, Dept Neurosurg, Shenzhen Key Lab Neurosurg, Affiliated Hosp 1,Shenzhen Peoples Hosp 2, Shenzhen 518035, Peoples R China
5.Capital Med Univ, Beijing Chaoyang Hosp, Dept Ophthalmol, Beijing 100020, Peoples R China
6.Chinese Acad Sci, Inst Proc Engn, Beijing Key Lab Ion Liquids Clean Proc, Beijing 100190, Peoples R China
7.Chinese Acad Sci, Inst Proc Engn, State Key Lab Multiphase Complex Syst, Beijing 100190, Peoples R China
8.Med Sch Chinese PLA, Beijing 100853, Peoples R China
Recommended Citation
GB/T 7714
Zhao, Jiawei,Wang, Yugang,Wang, Wenjing,et al. In situ growth of nano-antioxidants on cellular vesicles for efficient reactive oxygen species elimination in acute inflammatory diseases[J]. NANO TODAY,2021,40:17.
APA Zhao, Jiawei.,Wang, Yugang.,Wang, Wenjing.,Tian, Ying.,Gan, Zhongdong.,...&Ma, Guanghui.(2021).In situ growth of nano-antioxidants on cellular vesicles for efficient reactive oxygen species elimination in acute inflammatory diseases.NANO TODAY,40,17.
MLA Zhao, Jiawei,et al."In situ growth of nano-antioxidants on cellular vesicles for efficient reactive oxygen species elimination in acute inflammatory diseases".NANO TODAY 40(2021):17.
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