Knowledge Management System Of Institute of process engineering,CAS
| In situ growth of nano-antioxidants on cellular vesicles for efficient reactive oxygen species elimination in acute inflammatory diseases | |
| Zhao, Jiawei1,2; Wang, Yugang2; Wang, Wenjing1,4; Tian, Ying1,5; Gan, Zhongdong1; Wang, Yanlei3,6; He, Hongyan3,6; Chen, Wei7; Zhang, Xiao1; Wu, Yuanbin8; Jia, Rongrong2; Shi, Min2; Wei, Wei1,3; Ma, Guanghui1,3 | |
| 2021-10-01 | |
| Source Publication | NANO TODAY
 |
| ISSN | 1748-0132 |
| Volume | 40Pages:17 |
| Abstract | Reactive oxygen species (ROS) are key contributors to inflammatory progression and damage. Upon clinical and experimental observation of vascular abnormalities in acute inflammatory diseases, we explore cellular vesicles as templates and carriers to elevate therapeutic performance of nano-antioxidant. Specifically, we develop a mild one-pot approach for in situ growth of cerium oxide (Ce) nanocrystals onto nano-sized red blood cells vesicles (ReVs). Besides excellent biocompatibility, Ce-ReVs have very high ROS-scavenging activity, which is experimentally and theoretically explained by discovering the unique functions of membrane lipids in optimizing Ce nanocrystals with ultrasmall size (similar to 3 nm) and ultrahigh Ce(III) content (similar to 60.8%). In colitis and acute liver injury models, Ce-ReVs notably enhance accumulation at the inflamed sites and confer strong ROS elimination. Moreover, we upgrade the system by hybridizing ReVs with mesenchymal stem cell-derived exosomes and demonstrate additional repair function of highly damaged tissues, further verifying the satisfactory flexibility and therapeutic efficacy. (C) 2021 The Author(s). Published by Elsevier Ltd. |
| Keyword | Colitis Cerium oxide Inflammatory diseases Reactive oxygen species |
| DOI | 10.1016/j.nantod.2021.101282 |
| Language | 英语 |
| WOS Keyword | OXIDATIVE STRESS ; NANOPARTICLES ; METABOLISM ; DYNAMICS ; CERIA ; DRUG |
| Funding Project | National Natural Science Foundation of China[81871912] ; National Natural Science Foundation of China[81970530] ; National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[32030062] ; National Natural Science Foundation of China[U2001224] ; Shanghai Municipal Health Bureau Key Disciplines Grant[ZK2019C012] ; National Science and Technology Major Project of China[2018ZX10301-103-003] |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| WOS Subject | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
| Funding Organization | National Natural Science Foundation of China ; Shanghai Municipal Health Bureau Key Disciplines Grant ; National Science and Technology Major Project of China |
| WOS ID | WOS:000703972200003 |
| Publisher | ELSEVIER SCI LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/50412 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Shi, Min; Wei, Wei; Ma, Guanghui |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Shanghai Jiao Tong Univ, Tongren Hosp, Dept Gastroenterol, Sch Med, Shanghai 200336, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 4.Shenzhen Univ, Dept Neurosurg, Shenzhen Key Lab Neurosurg, Affiliated Hosp 1,Shenzhen Peoples Hosp 2, Shenzhen 518035, Peoples R China 5.Capital Med Univ, Beijing Chaoyang Hosp, Dept Ophthalmol, Beijing 100020, Peoples R China 6.Chinese Acad Sci, Inst Proc Engn, Beijing Key Lab Ion Liquids Clean Proc, Beijing 100190, Peoples R China 7.Chinese Acad Sci, Inst Proc Engn, State Key Lab Multiphase Complex Syst, Beijing 100190, Peoples R China 8.Med Sch Chinese PLA, Beijing 100853, Peoples R China |
| Recommended Citation GB/T 7714 | Zhao, Jiawei,Wang, Yugang,Wang, Wenjing,et al. In situ growth of nano-antioxidants on cellular vesicles for efficient reactive oxygen species elimination in acute inflammatory diseases[J]. NANO TODAY,2021,40:17. |
| APA | Zhao, Jiawei.,Wang, Yugang.,Wang, Wenjing.,Tian, Ying.,Gan, Zhongdong.,...&Ma, Guanghui.(2021).In situ growth of nano-antioxidants on cellular vesicles for efficient reactive oxygen species elimination in acute inflammatory diseases.NANO TODAY,40,17. |
| MLA | Zhao, Jiawei,et al."In situ growth of nano-antioxidants on cellular vesicles for efficient reactive oxygen species elimination in acute inflammatory diseases".NANO TODAY 40(2021):17. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment