CAS OpenIR
Enhancing therapeutic performance of personalized cancer vaccine via delivery vectors
Ye, Tong1,2; Li, Feng1,2; Ma, Guanghui1,2; Wei, Wei1,2
2021-10-01
Source PublicationADVANCED DRUG DELIVERY REVIEWS
ISSN0169-409X
Volume177Pages:23
AbstractIn recent years, personalized cancer vaccines have gained increasing attention as emerging immunother-apies with the capability to overcome interindividual differences and show great benefits for individual patients in the clinic due to the highly tailored vaccine formulations. A large number of materials have been studied as delivery vectors to enhance the therapeutic performance of personalized cancer vaccines, including artificial materials, engineered microorganisms, cells and cell derivatives. These delivery vec-tors with distinct features are employed to change antigen biodistributions and to facilitate antigen uptake, processing and presentation, improving the strength, velocity, and duration of the immune response when delivered by different strategies. Here, we provide an overview of personalized cancer vaccine delivery vectors, describing their materials, physicochemical properties, delivery strategies and challenges for clinical transformation. (c) 2021 Elsevier B.V. All rights reserved.
KeywordNeoantigen Whole cancer cell vaccine Immunogenic cell death Liposome Polymer Microorganism Delivery strategy DC vaccine Precise medicine
DOI10.1016/j.addr.2021.113927
Language英语
WOS KeywordIMMUNOGENIC CELL-DEATH ; IMMUNE CHECKPOINT BLOCKADE ; DENDRITIC CELLS ; NANOPARTICLE VACCINES ; GRAPHENE OXIDE ; DRUG-DELIVERY ; LYMPH-NODE ; IN-VIVO ; TUMOR MICROENVIRONMENT ; ANTIGEN TRAFFICKING
Funding ProjectNational Natural Science Foundation of China[U2001224] ; National Natural Science Foundation of China[32030062] ; National Natural Science Foundation of China[21821005] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303]
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
Funding OrganizationNational Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
WOS IDWOS:000704290900008
PublisherELSEVIER
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/50501
Collection中国科学院过程工程研究所
Corresponding AuthorWei, Wei
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Ye, Tong,Li, Feng,Ma, Guanghui,et al. Enhancing therapeutic performance of personalized cancer vaccine via delivery vectors[J]. ADVANCED DRUG DELIVERY REVIEWS,2021,177:23.
APA Ye, Tong,Li, Feng,Ma, Guanghui,&Wei, Wei.(2021).Enhancing therapeutic performance of personalized cancer vaccine via delivery vectors.ADVANCED DRUG DELIVERY REVIEWS,177,23.
MLA Ye, Tong,et al."Enhancing therapeutic performance of personalized cancer vaccine via delivery vectors".ADVANCED DRUG DELIVERY REVIEWS 177(2021):23.
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