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A protein network-guided screen for cell cycle regulators in Drosophila
Guest, Stephen T.1; Yu, Jingkai2; Liu, Dongmei1; Hines, Julie A.1; Kashat, Maria A.1; Finley, Russell L., Jr.1,3,4; Finley, RL
2011-05-06
Source PublicationBMC SYSTEMS BIOLOGY
ISSN1752-0509
Volume5Issue:0Pages:文献号: 65
AbstractBackground: Large-scale RNAi-based screens are playing a critical role in defining sets of genes that regulate specific cellular processes. Numerous screens have been completed and in some cases more than one screen has examined the same cellular process, enabling a direct comparison of the genes identified in separate screens. Surprisingly, the overlap observed between the results of similar screens is low, suggesting that RNAi screens have relatively high levels of false positives, false negatives, or both.
KeywordDependent-kinase Inhibitor Rna Interference Screen Jak/stat Signaling Components Influenza-virus Replication Saccharomyces-cerevisiae Translation Initiation Caenorhabditis-elegans C-elegans Interactome Network Nteraction Map
SubtypeArticle
WOS HeadingsScience & Technology ; Life Sciences & Biomedicine
DOI10.1186/1752-0509-5-65
Indexed BySCI
Language英语
WOS KeywordDEPENDENT-KINASE INHIBITOR ; RNA INTERFERENCE SCREEN ; JAK/STAT SIGNALING COMPONENTS ; INFLUENZA-VIRUS REPLICATION ; SACCHAROMYCES-CEREVISIAE ; TRANSLATION INITIATION ; CAENORHABDITIS-ELEGANS ; C-ELEGANS ; INTERACTOME NETWORK ; INTERACTION MAP
WOS Research AreaMathematical & Computational Biology
WOS SubjectMathematical & Computational Biology
WOS IDWOS:000291881600002
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5052
Collection生化工程国家重点实验室
Corresponding AuthorFinley, RL
Affiliation1.Wayne State Univ, Sch Med, Ctr Mol Med & Genet, Detroit, MI 48201 USA
2.Chinese Acad Sci, Inst Proc Engn, Natl Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Wayne State Univ, Sch Med, Dept Biochem & Mol Biol, Detroit, MI 48201 USA
4.Karmanos Canc Inst, Detroit, MI 48201 USA
Recommended Citation
GB/T 7714
Guest, Stephen T.,Yu, Jingkai,Liu, Dongmei,et al. A protein network-guided screen for cell cycle regulators in Drosophila[J]. BMC SYSTEMS BIOLOGY,2011,5(0):文献号: 65.
APA Guest, Stephen T..,Yu, Jingkai.,Liu, Dongmei.,Hines, Julie A..,Kashat, Maria A..,...&Finley, RL.(2011).A protein network-guided screen for cell cycle regulators in Drosophila.BMC SYSTEMS BIOLOGY,5(0),文献号: 65.
MLA Guest, Stephen T.,et al."A protein network-guided screen for cell cycle regulators in Drosophila".BMC SYSTEMS BIOLOGY 5.0(2011):文献号: 65.
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