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Preparation, characterization and MRI application of carboxymethyl dextran coated magnetic nanoparticles
Liu, G.2; Hong, R. Y.1,2,3,4,5; Guo, L.6; Li, Y. G.6; Li, H. Z.4; Hong, RY
2011-05-15
Source PublicationAPPLIED SURFACE SCIENCE
ISSN0169-4332
Volume257Issue:15Pages:6711-6717
AbstractSuperparamagnetic nanoparticles functionalized with carboxymethyl dextran (CM-dextran) were synthesized by a two-step method. First, the magnetic nanoparticles (MNPs) coated with dextran (M(w) approximate to 20000) were prepared by co-precipitation of Fe(2+) and Fe(3+) ions. Then, dextran on the surface of MNPs reacted with monochloroacetic acid (MCA) in alkaline condition. The influences of temperature and reactant concentration on the amount of -COOH on the surface of nanoparticles were systematically studied. The obtained MNPs coated with CM-dextran were stable over the entire range of pH and NaCl concentration. The MRI experiment indicated that the CM-dextran MNPs could potentially be used as MRI contrast agents for magnetic resonance molecular imaging. (C) 2011 Elsevier B. V. All rights reserved.
KeywordCarboxymethyl Dextran Monochloroacetic Acid Mri Magnetic Nanoparticle
SubtypeArticle
WOS HeadingsScience & Technology ; Physical Sciences ; Technology
DOI10.1016/j.apsusc.2011.02.110
Indexed BySCI
Language英语
WOS KeywordIRON-OXIDE NANOPARTICLES ; FEPT NANOPARTICLES ; CONTRAST AGENTS ; GENE DELIVERY ; IN-VITRO ; PARTICLES ; POLYMER ; FLUIDS ; VIVO
WOS Research AreaChemistry ; Materials Science ; Physics
WOS SubjectChemistry, Physical ; Materials Science, Coatings & Films ; Physics, Applied ; Physics, Condensed Matter
WOS IDWOS:000289512500063
Citation statistics
Cited Times:46[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Version出版稿
Identifierhttp://ir.ipe.ac.cn/handle/122111/5053
Collection多相复杂系统国家重点实验室
Corresponding AuthorHong, RY
Affiliation1.Soochow Univ, Chem Engn Dept 199, SIP, Coll Chem Chem Engn & Mat Sci, Suzhou 215123, Jiangsu, Peoples R China
2.Soochow Univ, SIP, Key Lab Organ Synth Jiangsu Prov, Suzhou 215123, Jiangsu, Peoples R China
3.Fuzhou Univ, Coll Chem & Chem Engn, Fuzhou 350002, Peoples R China
4.Chinese Acad Sci, State Key Lab Multiphase Complex Syst, Inst Proc Engn, Beijing 100080, Peoples R China
5.Ningxia Univ, Coll Chem & Chem Engn, Yinchuan 750021, Peoples R China
6.Soochow Univ, MRI Div, Affiliated Hosp 1, Suzhou 215007, Peoples R China
Recommended Citation
GB/T 7714
Liu, G.,Hong, R. Y.,Guo, L.,et al. Preparation, characterization and MRI application of carboxymethyl dextran coated magnetic nanoparticles[J]. APPLIED SURFACE SCIENCE,2011,257(15):6711-6717.
APA Liu, G.,Hong, R. Y.,Guo, L.,Li, Y. G.,Li, H. Z.,&Hong, RY.(2011).Preparation, characterization and MRI application of carboxymethyl dextran coated magnetic nanoparticles.APPLIED SURFACE SCIENCE,257(15),6711-6717.
MLA Liu, G.,et al."Preparation, characterization and MRI application of carboxymethyl dextran coated magnetic nanoparticles".APPLIED SURFACE SCIENCE 257.15(2011):6711-6717.
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