CAS OpenIR
Advances in Functionalized Carriers Based on Graphene's Unique Biological Interface Effect
Yue, Hua1; Ma, Guanghui1,2
2021-10-15
Source PublicationACTA CHIMICA SINICA
ISSN0567-7351
Volume79Issue:10Pages:1244-1256
AbstractThe interaction of two-dimensional graphene and its derivatives with biological interfaces exhibits distinct properties and advantages over traditional dimensional particles, offering potential strategies for the design and development of functionalized pharmaceutical carriers. Apart from the excellent electrical, thermal and optical properties, the two-dimensional structure endows the graphene stronger interactions with cell membranes and then induces obvious cellular response. These responses include the horizontal friction/slant insertion or sandwiched superstructure, selective internalization by phagocytes, folding effect upon the limited intracellular space, autophagy phenomenon and invisible activation. Based on these unique interfacial effects and theoretical simulation mechanisms, rational designs will meet the needs of drug delivery, vaccine carriers, imaging and sensing, and photothermal therapy as well as good biosafety. This review concludes our researches of exploring the biological interface effects, dynamic molecular mechanism, and applications regarding graphene (oxide) in the past 10 years. Meanwhile, it also covers the latest international progress, in order to provide theoretical basis and prospective prediction for the design, construction, and application of efficient and safe graphene systems.
Keywordgraphene biological interface effect 2D carrier drug delivery vaccine adjuvant
DOI10.6023/A21050238
Language英语
WOS KeywordGENE DELIVERY ; QUANTUM DOTS ; OXIDE ; CYTOTOXICITY ; SIZE ; NANOPARTICLES ; FLUORESCENCE ; MECHANISMS ; MEMBRANES ; ADJUVANT
Funding ProjectBeijing Municipal Natural Science Foundation[2202056] ; Key Program of National Natural Science Foundation of China[32030062]
WOS Research AreaChemistry
WOS SubjectChemistry, Multidisciplinary
Funding OrganizationBeijing Municipal Natural Science Foundation ; Key Program of National Natural Science Foundation of China
WOS IDWOS:000708054800005
PublisherSCIENCE PRESS
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Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/50608
Collection中国科学院过程工程研究所
Corresponding AuthorMa, Guanghui
Affiliation1.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yue, Hua,Ma, Guanghui. Advances in Functionalized Carriers Based on Graphene's Unique Biological Interface Effect[J]. ACTA CHIMICA SINICA,2021,79(10):1244-1256.
APA Yue, Hua,&Ma, Guanghui.(2021).Advances in Functionalized Carriers Based on Graphene's Unique Biological Interface Effect.ACTA CHIMICA SINICA,79(10),1244-1256.
MLA Yue, Hua,et al."Advances in Functionalized Carriers Based on Graphene's Unique Biological Interface Effect".ACTA CHIMICA SINICA 79.10(2021):1244-1256.
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