CAS OpenIR
Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases
Ji, Weihong1,3; Li, Yan1,2; Peng, Huan1,3; Zhao, Ruichen1,3; Zhang, Xin1
2022
Source PublicationADVANCED DRUG DELIVERY REVIEWS
ISSN0169-409X
Volume180Pages:24
AbstractGene therapy has great potential to treat brain diseases. However, genetic drugs need to overcome a cascade of barriers for their full potential. The conventional delivery systems often struggle to meet expectations. Natural biological particles that are highly optimized for specific functions in body, can inspire optimization of dynamic gene-loaded nanoassemblies (DGN). The DGN refer to gene loaded nanoassemblies whose functions and structures are changeable in response to the biological microenvironments or can dynamically interact with tissues or cells. The nature-inspired DGN can meet the needs in brain diseases treatment, including i) Non-elimination in blood (N), ii) Across the blood-brain barrier (A), iii) Targeting cells (T), iv) Efficient uptake (U), v) Controllable release (R), vi) Eyeable (E)-abbreviated as the "NATURE". In this Review, from nature to "NATURE", we mainly summarize the specific application of nature-inspired DGN in the "NATURE" cascade process. Furthermore, the Review provides an outlook for this field. (c) 2021 Elsevier B.V. All rights reserved.
KeywordNature-inspired Nanoassemblies Drug delivery systems Delivery barriers Gene therapy Brain disease Pathological microenvironment Stimuli-responsive
DOI10.1016/j.addr.2021.114029
Language英语
WOS KeywordSTIMULI-RESPONSIVE NANOCARRIERS ; CELL-PENETRATING PEPTIDES ; SMALL INTERFERING RNA ; MEMBRANE-CAMOUFLAGED NANOPARTICLES ; DRUG-DELIVERY SYSTEM ; GOLD NANOPARTICLES ; ENDOSOMAL ESCAPE ; CONTRAST AGENTS ; SIRNA DELIVERY ; IN-VITRO
Funding ProjectBeijing Natural Science[2192057] ; National High Technology Research and Development Program[2016YFA0200303] ; National Natural Science of China[32071391] ; National Natural Science of China[52073287] ; National Natural Science of China[22075289] ; National Natural Science of China[21905283] ; National Natural Science of China[31771095] ; National Natural Science of China[21875254] ; Beijing Nova Program[Z201100006820140]
WOS Research AreaPharmacology & Pharmacy
WOS SubjectPharmacology & Pharmacy
Funding OrganizationBeijing Natural Science ; National High Technology Research and Development Program ; National Natural Science of China ; Beijing Nova Program
WOS IDWOS:000723581900002
PublisherELSEVIER
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/51229
Collection中国科学院过程工程研究所
Corresponding AuthorZhang, Xin
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing 100083, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Ji, Weihong,Li, Yan,Peng, Huan,et al. Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases[J]. ADVANCED DRUG DELIVERY REVIEWS,2022,180:24.
APA Ji, Weihong,Li, Yan,Peng, Huan,Zhao, Ruichen,&Zhang, Xin.(2022).Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases.ADVANCED DRUG DELIVERY REVIEWS,180,24.
MLA Ji, Weihong,et al."Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases".ADVANCED DRUG DELIVERY REVIEWS 180(2022):24.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ji, Weihong]'s Articles
[Li, Yan]'s Articles
[Peng, Huan]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ji, Weihong]'s Articles
[Li, Yan]'s Articles
[Peng, Huan]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ji, Weihong]'s Articles
[Li, Yan]'s Articles
[Peng, Huan]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.