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| Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases | |
| Ji, Weihong1,3; Li, Yan1,2; Peng, Huan1,3; Zhao, Ruichen1,3; Zhang, Xin1 | |
| 2022 | |
| Source Publication | ADVANCED DRUG DELIVERY REVIEWS
 |
| ISSN | 0169-409X |
| Volume | 180Pages:24 |
| Abstract | Gene therapy has great potential to treat brain diseases. However, genetic drugs need to overcome a cascade of barriers for their full potential. The conventional delivery systems often struggle to meet expectations. Natural biological particles that are highly optimized for specific functions in body, can inspire optimization of dynamic gene-loaded nanoassemblies (DGN). The DGN refer to gene loaded nanoassemblies whose functions and structures are changeable in response to the biological microenvironments or can dynamically interact with tissues or cells. The nature-inspired DGN can meet the needs in brain diseases treatment, including i) Non-elimination in blood (N), ii) Across the blood-brain barrier (A), iii) Targeting cells (T), iv) Efficient uptake (U), v) Controllable release (R), vi) Eyeable (E)-abbreviated as the "NATURE". In this Review, from nature to "NATURE", we mainly summarize the specific application of nature-inspired DGN in the "NATURE" cascade process. Furthermore, the Review provides an outlook for this field. (c) 2021 Elsevier B.V. All rights reserved. |
| Keyword | Nature-inspired Nanoassemblies Drug delivery systems Delivery barriers Gene therapy Brain disease Pathological microenvironment Stimuli-responsive |
| DOI | 10.1016/j.addr.2021.114029 |
| Language | 英语 |
| WOS Keyword | STIMULI-RESPONSIVE NANOCARRIERS ; CELL-PENETRATING PEPTIDES ; SMALL INTERFERING RNA ; MEMBRANE-CAMOUFLAGED NANOPARTICLES ; DRUG-DELIVERY SYSTEM ; GOLD NANOPARTICLES ; ENDOSOMAL ESCAPE ; CONTRAST AGENTS ; SIRNA DELIVERY ; IN-VITRO |
| Funding Project | Beijing Natural Science[2192057] ; National High Technology Research and Development Program[2016YFA0200303] ; National Natural Science of China[32071391] ; National Natural Science of China[52073287] ; National Natural Science of China[22075289] ; National Natural Science of China[21905283] ; National Natural Science of China[31771095] ; National Natural Science of China[21875254] ; Beijing Nova Program[Z201100006820140] |
| WOS Research Area | Pharmacology & Pharmacy |
| WOS Subject | Pharmacology & Pharmacy |
| Funding Organization | Beijing Natural Science ; National High Technology Research and Development Program ; National Natural Science of China ; Beijing Nova Program |
| WOS ID | WOS:000723581900002 |
| Publisher | ELSEVIER |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/51229 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Zhang, Xin |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing 100083, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Ji, Weihong,Li, Yan,Peng, Huan,et al. Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases[J]. ADVANCED DRUG DELIVERY REVIEWS,2022,180:24. |
| APA | Ji, Weihong,Li, Yan,Peng, Huan,Zhao, Ruichen,&Zhang, Xin.(2022).Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases.ADVANCED DRUG DELIVERY REVIEWS,180,24. |
| MLA | Ji, Weihong,et al."Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases".ADVANCED DRUG DELIVERY REVIEWS 180(2022):24. |
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