CAS OpenIR
Shielding Ferritin with a Biomineralized Shell Enables Efficient Modulation of Tumor Microenvironment and Targeted Delivery of Diverse Therapeutic Agents
Wang, Changlong1,2; Wang, Xiaojun3; Zhang, Wei4,5,6; Ma, Ding4,5,6; Li, Feng1,2; Jia, Rongrong7; Shi, Min7; Wang, Yugang7; Ma, Guanghui1,2; Wei, Wei1,2
2021-12-13
Source PublicationADVANCED MATERIALS
ISSN0935-9648
Pages16
AbstractFerritin (Fn) is considered a promising carrier for targeted delivery to tumors, but the successful application in vivo has not been fully achieved yet. Herein, strong evidence is provided that the Fn receptor is expressed in liver tissues, resulting in an intercept effect in regards to tumor delivery. Building on these observations, a biomineralization technology is rationally designed to shield Fn using a calcium phosphate (CaP) shell, which can improve the delivery performance by reducing Fn interception in the liver while re-exposing it in acidic tumors. Moreover, the selective dissolution of the CaP shell not only neutralizes the acidic microenvironment but also induces the intratumoral immunomodulation and calcification. Upon multiple cell line and patient-derived xenografts, it is demonstrated that the elaboration of the highly flexible Fn@CaP chassis by loading a chemotherapeutic drug into the Fn cavity confers potent antitumor effects, and additionally encapsulating a photosensitizer into the outer shell enables a combined chemo-photothermal therapy for complete suppression of advanced tumors. Altogether, these results support Fn@CaP as a new nanoplatform for efficient modulation of the tumor microenvironment and targeted delivery of diverse therapeutic agents.
Keywordbiomineralization ferritin synergistic therapy tumor microenvironment
DOI10.1002/adma.202107150
Language英语
WOS KeywordHUMAN SERUM-ALBUMIN ; CALCIUM-PHOSPHATE ; H-FERRITIN ; NANOPARTICLES ; MAGNETOFERRITIN ; BINDING ; BRAIN ; LIVER
Funding ProjectNational Natural Science Foundation of China[U2001224] ; National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[32030062] ; National Natural Science Foundation of China[21725301] ; National Natural Science Foundation of China[21821004]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Natural Science Foundation of China
WOS IDWOS:000729432900001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/51347
Collection中国科学院过程工程研究所
Corresponding AuthorWei, Wei
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
3.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Dept Neurosurg, Shenzhen 518039, Peoples R China
4.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Engn, Beijing 100871, Peoples R China
5.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
6.Peking Univ, BIC ESAT, Beijing 100871, Peoples R China
7.Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Gastroenterol, Shanghai 200336, Peoples R China
Recommended Citation
GB/T 7714
Wang, Changlong,Wang, Xiaojun,Zhang, Wei,et al. Shielding Ferritin with a Biomineralized Shell Enables Efficient Modulation of Tumor Microenvironment and Targeted Delivery of Diverse Therapeutic Agents[J]. ADVANCED MATERIALS,2021:16.
APA Wang, Changlong.,Wang, Xiaojun.,Zhang, Wei.,Ma, Ding.,Li, Feng.,...&Wei, Wei.(2021).Shielding Ferritin with a Biomineralized Shell Enables Efficient Modulation of Tumor Microenvironment and Targeted Delivery of Diverse Therapeutic Agents.ADVANCED MATERIALS,16.
MLA Wang, Changlong,et al."Shielding Ferritin with a Biomineralized Shell Enables Efficient Modulation of Tumor Microenvironment and Targeted Delivery of Diverse Therapeutic Agents".ADVANCED MATERIALS (2021):16.
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