Knowledge Management System Of Institute of process engineering,CAS
| Kinetics and population balance modeling of antisolvent crystallization of polymorphic indomethacin | |
| Yang, Li1,2; Zhang, Yan1; Liu, Peng1,2; Wang, Chongqing1,3; Qu, Yanli1,2; Cheng, Jingcai1,4; Yang, Chao1,2 | |
| 2022-01-15 | |
| Source Publication | CHEMICAL ENGINEERING JOURNAL
 |
| ISSN | 1385-8947 |
| Volume | 428Pages:14 |
| Abstract | This work focuses on an important problem that is the modeling and control of polymorphic crystallization of indomethacin (IMC) in which one of the crystal forms consists of hair-like crystals. The lack of kinetic knowledge impedes the seeking for methods of efficient polymorph control of IMC. Herein, kinetics of antisolvent crystallization of alpha-IMC and gamma-IMC were first time determined on the basis of experiments and the population balance equation (PBE). It was found that gamma-IMC has an advantage in the secondary nucleation rate. A higher temperature was more unfavorable for obtaining gamma-IMC under the same supersaturation because the gamma-IMC was at a disadvantage in both primary nucleation and growth rates. According to the results of population balance modeling, the primary nucleation rate of gamma-IMC only affected the polymorphic composition at the early stage of antisolvent crystallization. The growth rate of alpha-IMC is the key in effectively controlling the polymorph outcome. |
| Keyword | Antisolvent crystallization Kinetics modeling Indomethacin Population balance equation Polymorph control |
| DOI | 10.1016/j.cej.2021.132591 |
| Language | 英语 |
| WOS Keyword | CRYSTAL SIZE DISTRIBUTION ; PRECIPITATION ; NUCLEATION ; GROWTH ; TRANSFORMATION ; OPTIMIZATION ; AGGREGATION ; SIMULATION |
| Funding Project | National Natural Science Foundation of China[21938009] ; National Natural Science Foundation of China[21776284] ; National Natural Science Foundation of China[21878294] ; National Natural Science Foundation of China[22078332] ; National Key Research and Development Program[2019YFC1904204] ; NSFC-EU project[31961133018] ; External Cooperation Program of BIC, Chinese Academy of Sciences[122111KYSB20190032] ; Chemistry and Chemical Engineering Guangdong Laboratory[1922006] |
| WOS Research Area | Engineering |
| WOS Subject | Engineering, Environmental ; Engineering, Chemical |
| Funding Organization | National Natural Science Foundation of China ; National Key Research and Development Program ; NSFC-EU project ; External Cooperation Program of BIC, Chinese Academy of Sciences ; Chemistry and Chemical Engineering Guangdong Laboratory |
| WOS ID | WOS:000729474600007 |
| Publisher | ELSEVIER SCIENCE SA |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/51416 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Cheng, Jingcai |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 3.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China 4.Chinese Acad Sci, Innovat Acad Green Manufacture, Beijing 100190, Peoples R China |
| Recommended Citation GB/T 7714 | Yang, Li,Zhang, Yan,Liu, Peng,et al. Kinetics and population balance modeling of antisolvent crystallization of polymorphic indomethacin[J]. CHEMICAL ENGINEERING JOURNAL,2022,428:14. |
| APA | Yang, Li.,Zhang, Yan.,Liu, Peng.,Wang, Chongqing.,Qu, Yanli.,...&Yang, Chao.(2022).Kinetics and population balance modeling of antisolvent crystallization of polymorphic indomethacin.CHEMICAL ENGINEERING JOURNAL,428,14. |
| MLA | Yang, Li,et al."Kinetics and population balance modeling of antisolvent crystallization of polymorphic indomethacin".CHEMICAL ENGINEERING JOURNAL 428(2022):14. |
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