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| Synthesis of red/black phosphorus-based composite nanosheets with a Z-scheme heterostructure for high-performance cancer phototherapy | |
| Kang, Yong1,2; Li, Zhengjun1; Lu, Fengying1; Su, Zhiguo1; Ji, Xiaoyuan3; Zhang, Songping1 | |
| 2021-12-10 | |
| Source Publication | NANOSCALE
 |
| ISSN | 2040-3364 |
| Pages | 14 |
| Abstract | Two dimensional black phosphorus nanosheets (BP NSs) have attracted plenty of attention in the research field of cancer photonic therapy. However, the poor stability and relatively low efficiency of reactive oxygen species (ROS) generation of BP NSs limit their practical application. To address these drawbacks, herein we report a red/black phosphorus (RP/BP) composite nanosheet, M-RP/BP@ZnFe2O4, which was synthesized by (1) partially converting red phosphorus (RP) to black phosphorus (BP) followed by liquid-phase ultrasonic exfoliation to form RP/BP NSs, (2) in situ synthesis of ZnFe2O4 nanoparticles on the surface of RP/BP NSs, (3) and wrapping with the MCF-7 cell membrane. Due to the presence of RP, BP, ZnFe2O4 and the cell membrane, the M-RP/BP@ZnFe2O4 NSs exhibited high performance in cancer phototherapy with the following features: (i) a Z-scheme heterojunction structure was formed between RP/BP NSs thus enabling high separation efficiency of the photogenerated electrons and holes; (ii) the photoexcitation holes in the valence band of RP can break the tumor microenvironment by oxidizing glutathione; (iii) the NSs could decompose water to produce H2O2 and O-2, which can be further converted to toxic OH through the ZnFe2O4 catalyzed Fenton reaction and O-1(2) through energy transfer, respectively; and (iv) the cell membrane wrapping improved the targeting of the composite NSs at the tumor site and photonic therapy can be finally triggered by a 660 nm laser to convert O-2 to O-2(-) and O-1(2). The in vitro cytotoxicity experiments showed that more than 90% cells were killed after photodynamic therapy (PDT) at 0.3 mg mL(-1) M-RP/BP@ZnFe2O4 NSs, and the animal experiments with xenograft tumor model mice indicated that tumor growth was completely inhibited and the highest survival rate of 83.3% at 60 days post PDT was obtained. |
| DOI | 10.1039/d1nr07553e |
| Language | 英语 |
| WOS Keyword | RED PHOSPHORUS ; NANOPARTICLES ; BIOCOMPATIBILITY ; THERAPY ; SYSTEMS ; CARBON |
| Funding Project | National Natural Science Foundation of China[21676276] |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS Subject | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied |
| Funding Organization | National Natural Science Foundation of China |
| WOS ID | WOS:000733927200001 |
| Publisher | ROYAL SOC CHEMISTRY |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/51451 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Zhang, Songping |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China 3.Tianjin Univ, Acad Med Engn & Translat Med, Med Coll, Tianjin 300072, Peoples R China |
| Recommended Citation GB/T 7714 | Kang, Yong,Li, Zhengjun,Lu, Fengying,et al. Synthesis of red/black phosphorus-based composite nanosheets with a Z-scheme heterostructure for high-performance cancer phototherapy[J]. NANOSCALE,2021:14. |
| APA | Kang, Yong,Li, Zhengjun,Lu, Fengying,Su, Zhiguo,Ji, Xiaoyuan,&Zhang, Songping.(2021).Synthesis of red/black phosphorus-based composite nanosheets with a Z-scheme heterostructure for high-performance cancer phototherapy.NANOSCALE,14. |
| MLA | Kang, Yong,et al."Synthesis of red/black phosphorus-based composite nanosheets with a Z-scheme heterostructure for high-performance cancer phototherapy".NANOSCALE (2021):14. |
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