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Synthesis of red/black phosphorus-based composite nanosheets with a Z-scheme heterostructure for high-performance cancer phototherapy
Kang, Yong1,2; Li, Zhengjun1; Lu, Fengying1; Su, Zhiguo1; Ji, Xiaoyuan3; Zhang, Songping1
2021-12-10
Source PublicationNANOSCALE
ISSN2040-3364
Pages14
AbstractTwo dimensional black phosphorus nanosheets (BP NSs) have attracted plenty of attention in the research field of cancer photonic therapy. However, the poor stability and relatively low efficiency of reactive oxygen species (ROS) generation of BP NSs limit their practical application. To address these drawbacks, herein we report a red/black phosphorus (RP/BP) composite nanosheet, M-RP/BP@ZnFe2O4, which was synthesized by (1) partially converting red phosphorus (RP) to black phosphorus (BP) followed by liquid-phase ultrasonic exfoliation to form RP/BP NSs, (2) in situ synthesis of ZnFe2O4 nanoparticles on the surface of RP/BP NSs, (3) and wrapping with the MCF-7 cell membrane. Due to the presence of RP, BP, ZnFe2O4 and the cell membrane, the M-RP/BP@ZnFe2O4 NSs exhibited high performance in cancer phototherapy with the following features: (i) a Z-scheme heterojunction structure was formed between RP/BP NSs thus enabling high separation efficiency of the photogenerated electrons and holes; (ii) the photoexcitation holes in the valence band of RP can break the tumor microenvironment by oxidizing glutathione; (iii) the NSs could decompose water to produce H2O2 and O-2, which can be further converted to toxic OH through the ZnFe2O4 catalyzed Fenton reaction and O-1(2) through energy transfer, respectively; and (iv) the cell membrane wrapping improved the targeting of the composite NSs at the tumor site and photonic therapy can be finally triggered by a 660 nm laser to convert O-2 to O-2(-) and O-1(2). The in vitro cytotoxicity experiments showed that more than 90% cells were killed after photodynamic therapy (PDT) at 0.3 mg mL(-1) M-RP/BP@ZnFe2O4 NSs, and the animal experiments with xenograft tumor model mice indicated that tumor growth was completely inhibited and the highest survival rate of 83.3% at 60 days post PDT was obtained.
DOI10.1039/d1nr07553e
Language英语
WOS KeywordRED PHOSPHORUS ; NANOPARTICLES ; BIOCOMPATIBILITY ; THERAPY ; SYSTEMS ; CARBON
Funding ProjectNational Natural Science Foundation of China[21676276]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
Funding OrganizationNational Natural Science Foundation of China
WOS IDWOS:000733927200001
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/51451
Collection中国科学院过程工程研究所
Corresponding AuthorZhang, Songping
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, 19 Yuquan Rd, Beijing 100049, Peoples R China
3.Tianjin Univ, Acad Med Engn & Translat Med, Med Coll, Tianjin 300072, Peoples R China
Recommended Citation
GB/T 7714
Kang, Yong,Li, Zhengjun,Lu, Fengying,et al. Synthesis of red/black phosphorus-based composite nanosheets with a Z-scheme heterostructure for high-performance cancer phototherapy[J]. NANOSCALE,2021:14.
APA Kang, Yong,Li, Zhengjun,Lu, Fengying,Su, Zhiguo,Ji, Xiaoyuan,&Zhang, Songping.(2021).Synthesis of red/black phosphorus-based composite nanosheets with a Z-scheme heterostructure for high-performance cancer phototherapy.NANOSCALE,14.
MLA Kang, Yong,et al."Synthesis of red/black phosphorus-based composite nanosheets with a Z-scheme heterostructure for high-performance cancer phototherapy".NANOSCALE (2021):14.
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