Knowledge Management System Of Institute of process engineering,CAS
| p Recent advances in platelet engineering for anti-cancer therapies | |
| Lv, Yanlin1; Wei, Wei1,2; Ma, Guanghui1,2 | |
| 2022-05-01 | |
| Source Publication | PARTICUOLOGY
 |
| ISSN | 1674-2001 |
| Volume | 64Pages:2-13 |
| Abstract | Platelets contribute a major role in hemostasis by clumping and coagulation at the site of blood vessel injuries. In light of recent findings of a close relationship between platelets and immunological response, as well as interactions between platelets and cancer cells, novel engineering strategies have emerged for the integration of platelets or platelet membrane (PM) with anti-cancer therapeutics. In this review, we discuss several recent innovations that use platelets or their membranes to circumvent host immune responses and target tumor cells with high specificity to deliver a range of pharmacological, photothermal, or immunologic agents for eradication of recalcitrant tumor cells. More specifically, we compare the relative advantages of using whole platelets versus single or hybrid PM to coat nanoparticle cargoes. These cargoes range from well-established anti-tumor apoptosis-inducing agents, to relatively new photothermal agents that can induce a feedback cascade in which they induce vascular damage to the tumor which recruits more platelet-or membrane-encapsulated agents to induce further damage. We also discuss the use of engineered platelets to produce programmed cell death-inducing platelet derived microparticles. This review provides an overview and future directions for this promising platelet-based biomimetic approach to anti-cancer therapy. (c) 2021 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/). |
| Keyword | Engineering platelets Platelet-mimicking Drug delivery Anti-cancer therapy |
| DOI | 10.1016/j.partic.2021.09.006 |
| Language | 英语 |
| WOS Keyword | DRUG-DELIVERY ; MEMBRANE ; NANOPARTICLES ; THROMBOSIS ; TUMORS ; CELLS |
| Funding Project | National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[21907096] ; National Natural Science Foundation of China[82072406] ; National Key R&D Program of China[2017YFA0207900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] |
| WOS Research Area | Engineering ; Materials Science |
| WOS Subject | Engineering, Chemical ; Materials Science, Multidisciplinary |
| Funding Organization | National Natural Science Foundation of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| WOS ID | WOS:000743069300002 |
| Publisher | ELSEVIER SCIENCE INC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/51670 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Ma, Guanghui |
| Affiliation | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China |
| Recommended Citation GB/T 7714 | Lv, Yanlin,Wei, Wei,Ma, Guanghui. p Recent advances in platelet engineering for anti-cancer therapies[J]. PARTICUOLOGY,2022,64:2-13. |
| APA | Lv, Yanlin,Wei, Wei,&Ma, Guanghui.(2022).p Recent advances in platelet engineering for anti-cancer therapies.PARTICUOLOGY,64,2-13. |
| MLA | Lv, Yanlin,et al."p Recent advances in platelet engineering for anti-cancer therapies".PARTICUOLOGY 64(2022):2-13. |
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