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| p A critical review of ferritin as a drug nanocarrier: Structure, properties, comparative advantages and challenges | |
| Yin, Shuang1; Davey, Kenneth1; Dai, Sheng2; Liu, Yongdong3; Bi, Jingxiu1 | |
| 2022-05-01 | |
| Source Publication | PARTICUOLOGY
 |
| ISSN | 1674-2001 |
| Volume | 64Pages:65-84 |
| Abstract | Ferritin stores and releases iron ions in mammals. It is globally important as a drug nanocarrier. This is because of its unique hollow-spherical structure, desirable stability and biological properties. Novel drug-loading approaches plus various functionalization approaches have been developed to improve ferritin in response to differing demands in disease treatments. Here, we critically review ferritin drug delivery and evaluate its diverse drug-loading and functionalization approaches, we: (1) Introduce basic structural and property information related to ferritin as a drug nanocarrier; (2) Contrast in detail the different means to load drugs and the selection of drug loading means; (3) Discuss multiple ferritin functionalization approaches, together with related advantages and potential risks; and, (4) Compare ferritin with alternative, commonly-used drug nanocarriers. We conclude that despite that no drugs based on ferritin are commercially available, the market potential for it is significant, and evaluate future research directions. Findings from this work will be of immediate benefit and interest to a wide range of researchers and manufacturers for drug delivery using ferritin. (c) 2021 Published by Elsevier B.V. on behalf of Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. |
| Keyword | Ferritin Drug delivery Drug nanocarrier Protein functionalization |
| DOI | 10.1016/j.partic.2021.04.020 |
| Language | 英语 |
| WOS Keyword | PROTEIN CAGE NANOPARTICLES ; IRON STORAGE PROTEIN ; DELIVERY SYSTEM ; H-CHAIN ; TUMOR MICROENVIRONMENT ; GOLD NANOPARTICLES ; CANCER-CELLS ; HALF-LIFE ; APOFERRITIN ; NANOCAGE |
| Funding Project | University of Adelaide ; Institute of Process Engineering, Chinese Academy of Sciences ; National Natural Science Foundation of China[21576267] ; Beijing Natural Science FoundaUtion[2162041] |
| WOS Research Area | Engineering ; Materials Science |
| WOS Subject | Engineering, Chemical ; Materials Science, Multidisciplinary |
| Funding Organization | University of Adelaide ; Institute of Process Engineering, Chinese Academy of Sciences ; National Natural Science Foundation of China ; Beijing Natural Science FoundaUtion |
| WOS ID | WOS:000743069300007 |
| Publisher | ELSEVIER SCIENCE INC |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/51688 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Liu, Yongdong; Bi, Jingxiu |
| Affiliation | 1.Univ Adelaide, Fac Engn Comp & Math Sci, Sch Chem Engn & Adv Mat, Adelaide, SA, Australia 2.Brunel Univ London, Dept Chem Engn, Uxbridge UB8 3PH, Middx, England 3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing, Peoples R China |
| Recommended Citation GB/T 7714 | Yin, Shuang,Davey, Kenneth,Dai, Sheng,et al. p A critical review of ferritin as a drug nanocarrier: Structure, properties, comparative advantages and challenges[J]. PARTICUOLOGY,2022,64:65-84. |
| APA | Yin, Shuang,Davey, Kenneth,Dai, Sheng,Liu, Yongdong,&Bi, Jingxiu.(2022).p A critical review of ferritin as a drug nanocarrier: Structure, properties, comparative advantages and challenges.PARTICUOLOGY,64,65-84. |
| MLA | Yin, Shuang,et al."p A critical review of ferritin as a drug nanocarrier: Structure, properties, comparative advantages and challenges".PARTICUOLOGY 64(2022):65-84. |
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