CAS OpenIR
Intranasal Administration of Self-Oriented Nanocarriers Based on Therapeutic Exosomes for Synergistic Treatment of Parkinson's Disease
Peng, Huan1,2; Li, Yan3; Ji, Weihong1,2; Zhao, Ruichen1,2; Lu, Zhiguo1,2; Shen, Jie1; Wu, Yanyue1; Wang, Jianze1; Hao, Qiulian1; Wang, Jingwen1; Wang, Wenli1; Yang, Jun1,2; Zhang, Xin1,2
2022-01-05
Source PublicationACS NANO
ISSN1936-0851
Pages16
AbstractThe treatment of Parkinson's disease (PD) has been hindered by the complex pathologies and multiple membrane barriers during drug delivery. Although exosomes derived from mesenchymal stem cells (MSCs) have great potential for PD, MSC-derived exosomes alone could not fully meet the therapeutic requirements due to their limitation in therapy and delivery. Here, we develop a self-oriented nanocarrier called PR-EXO/PP@Cur that combines therapeutic MSC-derived exosomes with curcumin. PR-EXO/PP@Cur can be self-oriented across the multiple membrane barriers and directly release drugs into the cytoplasm of target cells after intranasal administration. With enhanced accumulation of drugs in the action site, PR-EXO/PP@Cur achieves three- pronged synergistic treatment to deal with the complex pathologies of PD by reducing a-synuclein aggregates, promoting neuron function recovery, and alleviating the neuroinflammation. After treatment with PR-EXO/PP@Cur, the movement and coordination ability of PD model mice are significantly improved. These results show that PR-EXO/PP@Cur has great prospects in treatment of PD or other neurodegenerative diseases.
KeywordParkinson's disease MSC-derived exosomes self-oriented nanocarrier multiple membrane barriers intranasal administration three-pronged synergistic treatment
DOI10.1021/acsnano.1c08473
Language英语
WOS KeywordALPHA-SYNUCLEIN ; EXTRACELLULAR VESICLES ; COMMUNICATION ; INFLAMMATION ; MECHANISMS ; DELIVERY ; MIR-133B ; NEURONS ; CELLS
Funding ProjectNational Natural Science Foundation of China[21905283] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[32071391] ; National Natural Science Foundation of China[52073287] ; National Natural Science Foundation of China[22075289] ; Beijing Natural Science Foundation[2192057] ; Beijing Nova Program[Z201100006820140]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
Funding OrganizationNational Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Nova Program
WOS IDWOS:000742127900001
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/51722
Collection中国科学院过程工程研究所
Corresponding AuthorZhang, Xin
Affiliation1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
3.Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Peng, Huan,Li, Yan,Ji, Weihong,et al. Intranasal Administration of Self-Oriented Nanocarriers Based on Therapeutic Exosomes for Synergistic Treatment of Parkinson's Disease[J]. ACS NANO,2022:16.
APA Peng, Huan.,Li, Yan.,Ji, Weihong.,Zhao, Ruichen.,Lu, Zhiguo.,...&Zhang, Xin.(2022).Intranasal Administration of Self-Oriented Nanocarriers Based on Therapeutic Exosomes for Synergistic Treatment of Parkinson's Disease.ACS NANO,16.
MLA Peng, Huan,et al."Intranasal Administration of Self-Oriented Nanocarriers Based on Therapeutic Exosomes for Synergistic Treatment of Parkinson's Disease".ACS NANO (2022):16.
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