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| In Situ Generation of Gold Nanoparticles on Bacteria-Derived Magnetosomes for Imaging-Guided Starving/Chemodynamic/Photothermal Synergistic Therapy against Cancer | |
| Ye, Peng1,2; Li, Feng2,3; Zou, Jiale2,4; Luo, Ying1,2; Wang, Shuang2; Lu, Guihong2; Zhang, Fan2; Chen, Chang1; Long, Jiaxin1; Jia, Rongrong5; Shi, Min5; Wang, Yugang5; Cheng, Xiyu1; Ma, Guanghui2,3; Wei, Wei2,3 | |
| 2022-01-14 | |
| Source Publication | ADVANCED FUNCTIONAL MATERIALS
 |
| ISSN | 1616-301X |
| Pages | 17 |
| Abstract | There are several attractive opportunities for using magnetic nanomaterials for anticancer applications. Herein, a magnetic nanomaterial platform is successfully developed based on natural Fe3O4 magnetosomes extracted from the bacterium Magnetospirillum magneticum AMB-1 for anticancer therapy. The authors initially functionalize the magnetosome membranes in situ with gold nanoparticles to construct an attractive core-satellite structure. Subsequently, the physical properties and application potentials of these structures are characterized as contrast agents for photoacoustic imaging and magnetic resonance imaging and as therapeutic agents with selective magnetic field guidance for diverse antitumor modalities, including starving, chemodynamic, and photothermal therapies. Owing to the high-performance imaging-guided synergistic effect, only a single injection and single laser irradiation result in excellent therapeutic efficacy against tumor growth in multiple cell-derived xenograft tumor models and, most notably, patient-derived organoid and patient-derived xenograft tumor models. The demonstrations of the use of natural magnetic nanomaterials to achieve strong and synergistic antitumor performances highlight the promising application potential of this flexible and easy-to-prepare platform for developing innovative treatments for diseases in humans. |
| Keyword | magnetosomes synergistic therapies targeted deliveries |
| DOI | 10.1002/adfm.202110063 |
| Language | 英语 |
| WOS Keyword | MAGNETIC NANOPARTICLES |
| Funding Project | National Natural Science Foundation of China[U2001224] ; National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[32030062] ; National Key R&D Program of China[2017YFA0207900] ; Beijing Training Program of Innovation and Entrepreneurship for Undergraduates[202210004128] |
| WOS Research Area | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| WOS Subject | Chemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter |
| Funding Organization | National Natural Science Foundation of China ; National Key R&D Program of China ; Beijing Training Program of Innovation and Entrepreneurship for Undergraduates |
| WOS ID | WOS:000742542200001 |
| Publisher | WILEY-V C H VERLAG GMBH |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.ipe.ac.cn/handle/122111/51743 |
| Collection | 中国科学院过程工程研究所 |
| Corresponding Author | Cheng, Xiyu; Ma, Guanghui; Wei, Wei |
| Affiliation | 1.Beijing Jiaotong Univ, Sch Sci, Coll Life Sci & Bioengn, Beijing 100044, Peoples R China 2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 4.Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol & Hepatol, Med Ctr 1, Beijing 100853, Peoples R China 5.Shanghai Jiao Tong Univ, Dept Gastroenterol, Sch Med, Shanghai Tongren Hosp, Shanghai 200336, Peoples R China |
| Recommended Citation GB/T 7714 | Ye, Peng,Li, Feng,Zou, Jiale,et al. In Situ Generation of Gold Nanoparticles on Bacteria-Derived Magnetosomes for Imaging-Guided Starving/Chemodynamic/Photothermal Synergistic Therapy against Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2022:17. |
| APA | Ye, Peng.,Li, Feng.,Zou, Jiale.,Luo, Ying.,Wang, Shuang.,...&Wei, Wei.(2022).In Situ Generation of Gold Nanoparticles on Bacteria-Derived Magnetosomes for Imaging-Guided Starving/Chemodynamic/Photothermal Synergistic Therapy against Cancer.ADVANCED FUNCTIONAL MATERIALS,17. |
| MLA | Ye, Peng,et al."In Situ Generation of Gold Nanoparticles on Bacteria-Derived Magnetosomes for Imaging-Guided Starving/Chemodynamic/Photothermal Synergistic Therapy against Cancer".ADVANCED FUNCTIONAL MATERIALS (2022):17. |
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