CAS OpenIR
In Situ Generation of Gold Nanoparticles on Bacteria-Derived Magnetosomes for Imaging-Guided Starving/Chemodynamic/Photothermal Synergistic Therapy against Cancer
Ye, Peng1,2; Li, Feng2,3; Zou, Jiale2,4; Luo, Ying1,2; Wang, Shuang2; Lu, Guihong2; Zhang, Fan2; Chen, Chang1; Long, Jiaxin1; Jia, Rongrong5; Shi, Min5; Wang, Yugang5; Cheng, Xiyu1; Ma, Guanghui2,3; Wei, Wei2,3
2022-01-14
Source PublicationADVANCED FUNCTIONAL MATERIALS
ISSN1616-301X
Pages17
AbstractThere are several attractive opportunities for using magnetic nanomaterials for anticancer applications. Herein, a magnetic nanomaterial platform is successfully developed based on natural Fe3O4 magnetosomes extracted from the bacterium Magnetospirillum magneticum AMB-1 for anticancer therapy. The authors initially functionalize the magnetosome membranes in situ with gold nanoparticles to construct an attractive core-satellite structure. Subsequently, the physical properties and application potentials of these structures are characterized as contrast agents for photoacoustic imaging and magnetic resonance imaging and as therapeutic agents with selective magnetic field guidance for diverse antitumor modalities, including starving, chemodynamic, and photothermal therapies. Owing to the high-performance imaging-guided synergistic effect, only a single injection and single laser irradiation result in excellent therapeutic efficacy against tumor growth in multiple cell-derived xenograft tumor models and, most notably, patient-derived organoid and patient-derived xenograft tumor models. The demonstrations of the use of natural magnetic nanomaterials to achieve strong and synergistic antitumor performances highlight the promising application potential of this flexible and easy-to-prepare platform for developing innovative treatments for diseases in humans.
Keywordmagnetosomes synergistic therapies targeted deliveries
DOI10.1002/adfm.202110063
Language英语
WOS KeywordMAGNETIC NANOPARTICLES
Funding ProjectNational Natural Science Foundation of China[U2001224] ; National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[32030062] ; National Key R&D Program of China[2017YFA0207900] ; Beijing Training Program of Innovation and Entrepreneurship for Undergraduates[202210004128]
WOS Research AreaChemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
WOS SubjectChemistry, Multidisciplinary ; Chemistry, Physical ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied ; Physics, Condensed Matter
Funding OrganizationNational Natural Science Foundation of China ; National Key R&D Program of China ; Beijing Training Program of Innovation and Entrepreneurship for Undergraduates
WOS IDWOS:000742542200001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/51743
Collection中国科学院过程工程研究所
Corresponding AuthorCheng, Xiyu; Ma, Guanghui; Wei, Wei
Affiliation1.Beijing Jiaotong Univ, Sch Sci, Coll Life Sci & Bioengn, Beijing 100044, Peoples R China
2.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China
3.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
4.Chinese Peoples Liberat Army Gen Hosp, Dept Gastroenterol & Hepatol, Med Ctr 1, Beijing 100853, Peoples R China
5.Shanghai Jiao Tong Univ, Dept Gastroenterol, Sch Med, Shanghai Tongren Hosp, Shanghai 200336, Peoples R China
Recommended Citation
GB/T 7714
Ye, Peng,Li, Feng,Zou, Jiale,et al. In Situ Generation of Gold Nanoparticles on Bacteria-Derived Magnetosomes for Imaging-Guided Starving/Chemodynamic/Photothermal Synergistic Therapy against Cancer[J]. ADVANCED FUNCTIONAL MATERIALS,2022:17.
APA Ye, Peng.,Li, Feng.,Zou, Jiale.,Luo, Ying.,Wang, Shuang.,...&Wei, Wei.(2022).In Situ Generation of Gold Nanoparticles on Bacteria-Derived Magnetosomes for Imaging-Guided Starving/Chemodynamic/Photothermal Synergistic Therapy against Cancer.ADVANCED FUNCTIONAL MATERIALS,17.
MLA Ye, Peng,et al."In Situ Generation of Gold Nanoparticles on Bacteria-Derived Magnetosomes for Imaging-Guided Starving/Chemodynamic/Photothermal Synergistic Therapy against Cancer".ADVANCED FUNCTIONAL MATERIALS (2022):17.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ye, Peng]'s Articles
[Li, Feng]'s Articles
[Zou, Jiale]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ye, Peng]'s Articles
[Li, Feng]'s Articles
[Zou, Jiale]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ye, Peng]'s Articles
[Li, Feng]'s Articles
[Zou, Jiale]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.