CAS OpenIR
Self-assembly of Fmoc-amino acids in capillary confined space forming a parallel ordered fiber network for application in vascularization
Dong, Qianqian1,2,3; Wang, Meiyue3; Wang, Anhe3; Yu, Chunjing1,2; Bai, Shuo3; Yin, Jian2; You, Qingjun1,2
2022-01-28
Source PublicationBIOMATERIALS SCIENCE
ISSN2047-4830
Pages6
AbstractMatrices formed by self-assembly of amino acids and their derivatives are suitable for cell spreading, migration and proliferation, and widely used in tissue engineering and organ regeneration, due to the biological endogenous molecules and weak intermolecular forces. The self-assembly process is not only affected by dynamic and thermodynamic factors, but also the assembled space. In this work, capillary tubes with different diameters are chosen to mimic a confined environment and the effect of capillary space on the self-assembly behavior of Fmoc-amino acids with different oil-water partition coefficients (log P) was investigated. The amino acids can form special morphologies and structures through the limitation of the Brownian motion and the template effect exerted by a confined environment. Meanwhile, the obtained parallel ordered fiber network was applied to mimic the extracellular matrix (ECM) and support the adhesion and proliferation of monolayer flat epithelial cells (HUVECs). We believe that the exploration of the self-assembly of amino acids in confined space can promote the understanding of the supramolecular self-assembly mechanism and offer a great opportunity in building the specific structures of vessels or tissues in vitro.
DOI10.1039/d2bm00041e
Language英语
WOS KeywordPEPTIDE
Funding ProjectChinese Major Program for the National Key Research and Development Project[2020YFA0112603] ; project of Taihu Talent Plan ; Beijing Municipal Natural Science Foundation[7212206] ; National Natural Science Foundation of China[22072155] ; National Natural Science Foundation of China[22002170] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16020808]
WOS Research AreaMaterials Science
WOS SubjectMaterials Science, Biomaterials
Funding OrganizationChinese Major Program for the National Key Research and Development Project ; project of Taihu Talent Plan ; Beijing Municipal Natural Science Foundation ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
WOS IDWOS:000755738700001
PublisherROYAL SOC CHEMISTRY
Citation statistics
Document Type期刊论文
Identifierhttp://ir.ipe.ac.cn/handle/122111/51966
Collection中国科学院过程工程研究所
Corresponding AuthorBai, Shuo; Yin, Jian; You, Qingjun
Affiliation1.Jiangnan Univ, Dept Oncol, Affiliated Hosp, Wuxi 214062, Jiangsu, Peoples R China
2.Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Dong, Qianqian,Wang, Meiyue,Wang, Anhe,et al. Self-assembly of Fmoc-amino acids in capillary confined space forming a parallel ordered fiber network for application in vascularization[J]. BIOMATERIALS SCIENCE,2022:6.
APA Dong, Qianqian.,Wang, Meiyue.,Wang, Anhe.,Yu, Chunjing.,Bai, Shuo.,...&You, Qingjun.(2022).Self-assembly of Fmoc-amino acids in capillary confined space forming a parallel ordered fiber network for application in vascularization.BIOMATERIALS SCIENCE,6.
MLA Dong, Qianqian,et al."Self-assembly of Fmoc-amino acids in capillary confined space forming a parallel ordered fiber network for application in vascularization".BIOMATERIALS SCIENCE (2022):6.
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